全文获取类型
收费全文 | 778篇 |
免费 | 66篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 45篇 |
妇产科学 | 16篇 |
基础医学 | 147篇 |
口腔科学 | 12篇 |
临床医学 | 72篇 |
内科学 | 173篇 |
皮肤病学 | 18篇 |
神经病学 | 80篇 |
特种医学 | 23篇 |
外科学 | 101篇 |
综合类 | 7篇 |
预防医学 | 48篇 |
眼科学 | 9篇 |
药学 | 26篇 |
中国医学 | 1篇 |
肿瘤学 | 59篇 |
出版年
2023年 | 12篇 |
2022年 | 15篇 |
2021年 | 26篇 |
2020年 | 17篇 |
2019年 | 13篇 |
2018年 | 16篇 |
2017年 | 13篇 |
2016年 | 19篇 |
2015年 | 23篇 |
2014年 | 34篇 |
2013年 | 34篇 |
2012年 | 46篇 |
2011年 | 41篇 |
2010年 | 32篇 |
2009年 | 24篇 |
2008年 | 34篇 |
2007年 | 39篇 |
2006年 | 45篇 |
2005年 | 32篇 |
2004年 | 32篇 |
2003年 | 39篇 |
2002年 | 36篇 |
2001年 | 26篇 |
2000年 | 25篇 |
1999年 | 24篇 |
1998年 | 13篇 |
1997年 | 14篇 |
1996年 | 7篇 |
1995年 | 9篇 |
1992年 | 11篇 |
1991年 | 8篇 |
1990年 | 8篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 8篇 |
1984年 | 8篇 |
1983年 | 6篇 |
1981年 | 3篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1974年 | 4篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1970年 | 3篇 |
1969年 | 4篇 |
1958年 | 1篇 |
1912年 | 2篇 |
排序方式: 共有846条查询结果,搜索用时 15 毫秒
841.
Thomas Meyer Erma Salkic Torsten Grehl Ute Weyen Dagmar Kettemann Patrick Weydt René Günther Paul Lingor Jan Christoph Koch Susanne Petri Andreas Hermann Johannes Prudlo Julian Großkreutz Petra Baum Matthias Boentert Moritz Metelmann Jenny Norden Isabell Cordts Jochen H. Weishaupt Johannes Dorst Albert Ludolph Yasemin Koc Bertram Walter Christoph Münch Susanne Spittel Marie Dreger André Maier Péter Körtvélyessy 《European journal of neurology》2023,30(6):1600-1610
Background and purpose
The objective was to assess the performance of serum neurofilament light chain (sNfL) in amyotrophic lateral sclerosis (ALS) in a wide range of disease courses, in terms of progression, duration and tracheostomy invasive ventilation (TIV).Methods
A prospective cross-sectional study at 12 ALS centers in Germany was performed. sNfL concentrations were age adjusted using sNfL Z scores expressing the number of standard deviations from the mean of a control reference database and correlated to ALS duration and ALS progression rate (ALS-PR), defined by the decline of the ALS Functional Rating Scale.Results
In the total ALS cohort (n = 1378) the sNfL Z score was elevated (3.04; 2.46–3.43; 99.88th percentile). There was a strong correlation of sNfL Z score with ALS-PR (p < 0.001). In patients with long (5–10 years, n = 167) or very long ALS duration (>10 years, n = 94) the sNfL Z score was significantly lower compared to the typical ALS duration of <5 years (n = 1059) (p < 0.001). Furthermore, in patients with TIV, decreasing sNfL Z scores were found in correlation with TIV duration and ALS-PR (p = 0.002; p < 0.001).Conclusions
The finding of moderate sNfL elevation in patients with long ALS duration underlined the favorable prognosis of low sNfL. The strong correlation of sNfL Z score with ALS-PR strengthened its value as progression marker in clinical management and research. The lowering of sNfL in correlation with long TIV duration could reflect a reduction either in disease activity or in the neuroaxonal substrate of biomarker formation during the protracted course of ALS. 相似文献842.
Helena Isabell Riedemann Morna F. Schmidt Jens Malte Baron 《Journal der Deutschen Dermatologischen Gesellschaft》2023,21(7):761-776
A scar develops following the appearance of a deep tissue defect as part of the physiological wound healing process. The initial inflammatory response is followed by proliferation of connective tissue cells, which form fibrosis as a final tissue substitute. Disorders can occur at all stages of the process and are most commonly manifested as impaired wound healing or the formation of atrophic and hypertrophic scars or keloids. The focus of this article is on the treatment of pathologic scars, which are an indication for therapy due to functional limitations, complaints, and stigmatization, among other reasons. Conservative medical, physical, surgical and laser therapeutic approaches are pursued. The basis for this is an understanding of the pathophysiological mechanisms and factors influencing the choice of therapy, as well as an interdisciplinary and interprofessional therapeutic approach. 相似文献
843.
844.
David Mataix-Cols PhD Kayoko Isomura MD PhD Gustaf Brander PhD Isabell Brikell PhD Paul Lichtenstein PhD Zheng Chang PhD Henrik Larsson PhD Ralf Kuja-Halkola PhD Kevin J. Black MD Anna Sidorchuk MD PhD Lorena Fernández de la Cruz PhD 《Movement disorders》2023,38(8):1419-1427
Background
Many children with tic disorders outgrow their tics, but little is known about the proportion of individuals who will continue to require specialist services in adulthood and which variables are associated with tic persistence.Objectives
The aims were to estimate the proportion of individuals first diagnosed with tic disorders in childhood who continued to receive tic disorder diagnoses after age 18 years and to identify risk factors for persistence.Methods
In this Swedish nationwide cohort study including 3761 individuals diagnosed with tic disorders in childhood, we calculated the proportion of individuals whose diagnoses persisted into adulthood. Minimally adjusted logistic regression models examined the associations between sociodemographic, clinical, and family variables and tic disorder persistence. A multivariable model was then fitted, including only variables that were statistically significant in the minimally adjusted models.Results
Seven hundred and fifty-four (20%) children with tic disorders received a diagnosis of a chronic tic disorder in adulthood. Psychiatric comorbidity in childhood (particularly attention-deficit hyperactivity disorder, obsessive-compulsive disorder, pervasive developmental disorders, and anxiety disorders) and psychiatric disorders in first-degree relatives (particularly tic and anxiety disorders) were the strongest risk factors for persistence. We did not observe statistically significant associations with socioeconomic variables, perinatal complications, comorbid autoimmune diseases, or family history of autoimmune diseases. All statistically significant variables combined explained approximately 10% of the variance in tic disorder persistence (P < 0.0001).Conclusions
Childhood psychiatric comorbidities and family history of psychiatric disorders were the strongest risk factors associated with tic disorder persistence into adulthood. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 相似文献845.
846.
Thomas Birkner Doreen Siegels Luise Heinrich Eva Haufe Susanne Abraham Annice Heratizadeh Inken Harder Magnus Bell Isabell Fell Margitta Worm Christiane Handrick Isaak Effendy Andrea Asmussen Andreas Kleinheinz Bernhard Homey Michael Sticherling Sung-Hei Hong-Weldemann Matthias Augustin Elke Weisshaar Knut Schäkel Thomas Schaefer Beate Schwarz Franca Wiemers Jens-Joachim Brücher Sven Quist Andreas Wollenberg Tilo Biedermann Konstantin Ertner Ralph von Kiedrowski Thomas Werfel Stephan Weidinger Jochen Schmitt and the TREATgermany Study Group 《Journal der Deutschen Dermatologischen Gesellschaft》2023,21(10):1157-1168