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Imad Y. Saadeldin Reham M. Milhem Lihadh Al-Gazali Bassam R. Ali 《Pediatric neurology》2013,48(1):63-66
Mutations in voltage-gated potassium channel Kv7.2 are responsible for benign familial neonatal seizures type 1, a rare monogenic autosomal dominant inherited epilepsy syndrome. We describe a novel mutation (c.1126_1127delA) in exon 9 of KCNQ2, the gene encoding for the Kv7.2 channel, in a large Emirati family with benign familial neonatal seizures type 1. The mutation leads to a frameshift at amino acid position 376, triggering loss of function and haploinsufficiency. Patients with this mutation manifest repeated clonic seizures with normal interictal electroencephalograms and favorable prognoses. Signs occur within the first days of age, lingering well into puberty. KCNQ2 mutation screening, alongside genetic counseling, should be included in diagnostic evaluations of neonatal epileptic patients, potentially sparing the need for unnecessary investigations and treatment. To our knowledge, this report is the first of a KCNQ2 mutation in an Emirati family with benign familial neonatal seizures type 1. 相似文献
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Hussain A. Isma’eel George E. Sakr Robert H. Habib Mohamad Musbah Almedawar Nathalie K. Zgheib Imad H. Elhajj 《European journal of clinical pharmacology》2014,70(3):265-273
Background
The unpredictability of acenocoumarol dose needed to achieve target blood thinning level remains a challenge. We aimed to apply and compare a pharmacogenetic least-squares model (LSM) and artificial neural network (ANN) models for predictions of acenocoumarol dosing.Methods
LSM and ANN models were used to analyze previously collected data on 174 participants (mean age: 67.45 SD 13.49 years) on acenocoumarol maintenance therapy. The models were based on demographics, lifestyle habits, concomitant diseases, medication intake, target INR, and genotyping results for CYP2C9 and VKORC1. LSM versus ANN performance comparisons were done by two methods: by randomly splitting the data as 50 % derivation and 50 % validation cohort followed by a bootstrap of 200 iterations, and by a 10-fold leave-one-out cross-validation technique.Results
The ANN-based pharmacogenetic model provided higher accuracy and larger R value than all other LSM-based models. The accuracy percentage improvement ranged between 5 % and 24 % for the derivation cohort and between 12 % and 25 % for the validation cohort. The increase in R value ranged between 6 % and 31 % for the derivation cohort and between 2 % and 31 % for the validation cohort. ANN increased the percentage of accurately dosed subjects (mean absolute error ≤1 mg/week) by 14.1 %, reduced the percentage of mis-dosed subjects (mean absolute error 2-3 mg/week) by 7.04 %, and reduced the percentage of grossly mis-dosed subjects (mean absolute error ≥4 mg/week) by 24 %.Conclusions
ANN-based pharmacogenetic guidance of acenocoumarol dosing reduces the error in dosing to achieve target INR. These results need to be ascertained in a prospective study. 相似文献35.
Osama Hamid Ahmed Eltelbany Abdul Mohammed Khaled Alsabbagh Alchirazi Sushrut Trakroo Imad Asaad 《Annals of hepatology》2022,27(5):100727
Introduction and objectivesNon-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD) that can progress to liver cirrhosis, liver failure and hepatocellular carcinoma. It is the second leading cause of liver transplant in the US. We aim to investigate the prevalence, demographics and risk factors NASH patients in the US.Patients and methodsWe used a large database (Explorys IBM) that aggregates electronic health records from 26 nationwide healthcare systems. We identified adults with NASH between 2010-2020. Demographics including age, gender and race were collected. NASH risk factors including Diabetes Millets (DM), Hyperlipidemia (HLD), Hypertension (HTN) and Obesity were also collected. Cochran-Armitage test was used to assess the statistical significance of year-by-year trend. Univariable and multivariable logistic regression were used to estimate the odds ratio (OR) of risk factors.ResultsNASH annual prevalence rate increased from 1.51% in 2010 to 2.79% in 2020 (p < 0.0001). The proportion of patients with NASH by gender was 54.1% female vs 45.9% male (OR 1.04 [0.91-1.11]). Caucasian had higher odds of NASH than non-Caucasian (OR 1.42 [1.31-1.54]). NASH is strongly associated with DM and obesity (OR 18.61 [17.35-19.94]) and (OR 20.97 [17.87-23.21]), respectively. Other components of metabolic syndrome were associated with NASH to a lesser degree; HTN (OR 3.24 [3.20-3.28]) and HLD (OR 4.93 [4.85-4.01]).ConclusionThe prevalence of NASH has significantly increased in the US in the last decade. This is likely related to the increased prevalence of risk factors as well as increased awareness of the disease. 相似文献
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Francesco Giannini MD Matteo Pagnesi MD Gianluca Campo MD PhD Michael Donahue MD Luca A. Ferri MD Carlo Briguori MD PhD Giulio G. Stefanini MD PhD Raffaele Scardala MD Gennaro Sardella MD Salvatore De Rosa MD PhD Filippo Figini MD Alberto Monello MD Luigi E. Pastormerlo MD Luca Testa MD PhD Annamaria Nicolino MD Alfonso Ielasi MD Alessandro Durante MD Angelo Leone MD Giorgios Tzanis MD Antonio Mangieri MD Giovanni Ciccarelli MD Martina Briani MD Bernhard Reimers MD Andrea Ceccacci MD Ciro Indolfi MD Imad Sheiban MD Cataldo Palmieri MD Francesco Bedogni MD Maurizio Tespili MD Azeem Latib MD Francesco Gallo Antonio Colombo MD 《Catheterization and cardiovascular interventions》2021,97(3):411-420
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Yves Louvard MD Martyn Thomas MD Vladimir Dzavik MD David Hildick‐Smith MD Alfredo R. Galassi MD Manuel Pan MD Francisco Burzotta MD Michael Zelizko MD Darius Dudek MD Peter Ludman MD Imad Sheiban MD Jens F. Lassen MD Olivier Darremont MD Adnan Kastrati MD Josef Ludwig MD Ioannis Iakovou MD Philippe Brunel MD Alexandra Lansky MD David Meerkin MD Victor Legrand MD Alfonso Medina MD Thierry Lefèvre MD 《Catheterization and cardiovascular interventions》2008,71(2):175-183
38.
Benjamin E. Jenny Yassar Almanaseer 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2014,41(6):668-670
Infective endocarditis complicated by abscess formation and coronary artery compression is a rare clinical event with a high mortality rate, and diagnosis requires a heightened degree of suspicion. We present the clinical, angiographic, and echocardiographic features of a 73-year-old woman who presented with dyspnea and was found to have right coronary artery compression that was secondary to abscess formation resulting from diffuse infectious endocarditis. We discuss the patient''s case and briefly review the relevant medical literature. To our knowledge, this is the first reported case of abscess formation involving a native aortic valve and the right coronary artery. 相似文献
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