全文获取类型
收费全文 | 3612篇 |
免费 | 218篇 |
国内免费 | 41篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 99篇 |
妇产科学 | 100篇 |
基础医学 | 494篇 |
口腔科学 | 35篇 |
临床医学 | 340篇 |
内科学 | 1006篇 |
皮肤病学 | 84篇 |
神经病学 | 450篇 |
特种医学 | 72篇 |
外科学 | 304篇 |
综合类 | 7篇 |
预防医学 | 179篇 |
眼科学 | 78篇 |
药学 | 237篇 |
中国医学 | 4篇 |
肿瘤学 | 369篇 |
出版年
2024年 | 10篇 |
2023年 | 57篇 |
2022年 | 124篇 |
2021年 | 197篇 |
2020年 | 122篇 |
2019年 | 138篇 |
2018年 | 153篇 |
2017年 | 93篇 |
2016年 | 121篇 |
2015年 | 156篇 |
2014年 | 162篇 |
2013年 | 197篇 |
2012年 | 321篇 |
2011年 | 344篇 |
2010年 | 179篇 |
2009年 | 168篇 |
2008年 | 236篇 |
2007年 | 189篇 |
2006年 | 198篇 |
2005年 | 151篇 |
2004年 | 135篇 |
2003年 | 136篇 |
2002年 | 101篇 |
2001年 | 31篇 |
2000年 | 19篇 |
1999年 | 20篇 |
1998年 | 20篇 |
1997年 | 10篇 |
1996年 | 9篇 |
1995年 | 10篇 |
1994年 | 5篇 |
1993年 | 7篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 3篇 |
1986年 | 2篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1971年 | 2篇 |
排序方式: 共有3871条查询结果,搜索用时 0 毫秒
101.
102.
103.
Lotta LA Mancini I Tuana G Musallam KM Peyvandi F 《Journal of thrombosis and thrombolysis》2012,34(3):416-418
Thienopyridines are commonly used anti-platelet drugs that may be associated with the development of secondary, drug-induced thrombotic thrombocytopenic purpura (TTP), a rare but potentially life threatening condition. We report the case of a 70?year-old man with a history of recurrent idiopathic TTP episodes who was treated with clopidogrel and then ticlopidine for thromboprophylaxis after percutaneous coronary intervention. Treatment was successful with no signs of TTP recurrence. Platelet counts and ADAMTS13 activity levels remained normal for months after the initiation of anti-platelet therapy, with no reappearance of anti-ADAMTS13 autoantibodies. This report demonstrates that thienopyridines do not necessarily induce TTP in patients with a history of TTP who are in disease remission. 相似文献
104.
Fabbian F Casetta I De Giorgi A Pala M Tiseo R Portaluppi F Manfredini R 《Clinical and applied thrombosis/hemostasis》2012,18(3):305-311
Cerebrovascular disease may represent an important clinical presentation of atherosclerosis in chronic kidney disease (CKD), and atherosclerosis is frequently encountered in CKD. In fact, kidney disease is now considered a risk factor for development of cardiovascular disease. Although guidelines for primary prevention of stroke have been recently published, CKD is hardly mentioned. Based on a series of available studies, we analyzed the relationship between reduced renal function, end-stage renal disease (ESRD), and stroke. Reduced renal function and risk of stroke appear to be related to the highest risk of patients on dialysis treatment. Primary and secondary prevention of stroke should be encouraged in participants with renal dysfunction. 相似文献
105.
106.
107.
Govoni M Bombardieri S Bortoluzzi A Caniatti L Casu C Conti F De Vita S Doria A Farina I Ferraccioli G Gremese E Mansutti E Mosca M Padovan M Piga M Tincani A Tola MR Tomietto P Taglietti M Trotta F Valesini G Zen M Mathieu A;Italian Society of Rheumatology 《Rheumatology (Oxford, England)》2012,51(1):157-168
108.
Cimaz R Moretti D Pagnini I Marino A Cantarini L Simonini G 《Current rheumatology reports》2012,14(2):150-154
Classification of juvenile idiopathic arthritis is an ongoing process and up to now has been predominantly based on clinical
manifestations—mainly number of joints at onset of disease. In the meantime, basic studies have advanced our knowledge regarding
the disease pathogenesis. Unfortunately, studies of cytokines and cytokine polymorphisms have not followed the predominantly
clinical International League of Associations for Rheumatology classification in that no significant biological differences
among the different disease categories have been demonstrated with robust associations. Only systemic-onset disease seems
to be quite different from other disease categories with regard to biologic mechanisms; indeed, it now seems closer to autoinflammatory
than to classic autoimmune diseases. New players in the immunologic basis of juvenile idiopathic arthritis (eg, interleukin-17
and regulatory T cells) are also discussed in this review. 相似文献
109.
Almerighi C Bergamini A Lionetti R Sinistro A Lenci I Tariciotti L Tisone G Angelico M 《Digestive and liver disease》2012,44(1):67-73
Background
Aim of the present study was to investigate whether 1,25(OH)(2)D(3) (Vitamin D3) modulates T lymphocyte functions in patients transplanted for hepatitis C virus-related cirrhosis.Methods
Sixteen patients and ten healthy subjects were investigated. T lymphocytes were activated in vitro in the presence or absence of Vitamin D3 and then the proliferative response and IFN-γ and TNF-α production were assessed.Results
Vitamin D3 potently reduced T-lymphocyte proliferation in a dose-related fashion. Similarly, FACS analysis and ELISA testing demonstrated that Vitamin D3 significantly decreased the response frequency and the response intensity of IFN-γ and TNF-α production in the whole CD3-positive T lymphocyte population as well as in “naive” CD4+ CD45RA+ and “memory” CD4+ CD45RO+ T lymphocyte subsets. The inhibitory effect of Vitamin D3 on T-cell proliferation and cytokine production was not different between patients and controls. No toxic effects were exerted by Vitamin D3 even at the higher concentration used (10 nM). Finally, no statistically significant correlation was found between 25(OH)D serum levels and the proliferative response or cytokine production of T lymphocytes from transplanted patients.Conclusions
This study demonstrates that in patients transplanted for hepatitis C virus-related cirrhosis Vitamin D3 modulates T lymphocyte activation, and provides a rationale for the evaluation of this compound as an immunosuppressive agent in liver-transplanted patients. 相似文献110.
Rebecca L. Mather Abhijit Parolia Sandra E. Carson Erik Venalainen David RoigCarles Mustapha Jaber ShihChun Chu Ilaria Alborelli Rebecca Wu Dong Lin Noushin Nabavi Elena Jachetti Mario P. Colombo Hui Xue Perla Pucci Xinpei Ci Cheryl Hawkes Yinglei Li Hardev Pandha Igor Ulitsky Crystal Marconett Luca Quagliata Wei Jiang Ignacio Romero Yuzhuo Wang Francesco Crea 《Molecular oncology》2021,15(7):1921