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991.
Martínez-Salamanca JI Martínez-Ballesteros C Portillo L Gabancho S Moncada I Carballido J 《Archivos espa?oles de urología》2010,63(8):581-588
In these article we review the main mechanisms involved in human erection. We review and update in detail the biochemical (nitric oxide and Rho-kinase pathways), cellular (smooth muscle relaxation mechanisms), neural (autonomic and somatic pathways) and microscopic penile principles. 相似文献
992.
Ivan Macía Juan Moya Ricard Ramos Francisco Rivas Anna Ureña Gabriela Rosado Ignacio Escobar Juliet Toñanez Josep Saumench 《Cirugía espa?ola》2010,88(3):146-151
Primary hyperhidrosis-PH is an excessive sweating without known etiology. The PH is more frequent in women and in palms, soles and axillae. Medical treatment is not effective. The objective of the surgery is to remove or to disconnect sympathetic ganglia T2 (craniofacial PH or facial blushing), T3 (palmar PH) and T3–T4 (axillary PH). The surgical techniques are mainly resection/transection, ablation with electrocoagulation, sympathetic block by clipping and radiofrequency. Anhidrosis is achieved in 95% of the patients. The overall rate of complications is less than 5% and these are minor complications. The most important unwanted effect is reflex sweating, presented in 48% of the patients. Reflex sweating is more frequent in back, thorax and abdomen and it appears independently of the surgical technique. Ninety percent of the patients are very satisfied after surgery. Nowadays, thoracic sympathetic surgery is the gold standard for primary hyperhidrosis. 相似文献
993.
Constanze Reutlinger Ingo Helbig Barbara Gawelczyk Jose Ignacio Martin Subero Holger Tönnies Hiltrud Muhle Katrin Finsterwalder Sascha Vermeer Rolph Pfundt Jürgen Sperner Irina Stefanova Gabriele Gillessen‐Kaesbach Sarah Von Spiczak Andreas Van Baalen Rainer Boor Reiner Siebert Ulrich Stephani Almuth Caliebe 《Epilepsia》2010,51(9):1870-1873
Seizure disorders of the rolandic region comprise a spectrum of different epilepsy syndromes ranging from benign rolandic epilepsy to more severe seizure disorders including atypical benign partial epilepsy/pseudo‐Lennox syndrome, electrical status epilepticus during sleep, and Landau‐Kleffner syndrome. Centrotemporal spikes are the unifying electroencephalographic hallmark of these benign focal epilepsies, indicating a pathophysiologic relationship between the various epilepsies arising from the rolandic region. The etiology of these epilepsies is elusive, but a genetic component is assumed given the heritability of the characteristic electrographic trait. Herein we report on three patients with intellectual disability, various dysmorphic features, and epilepsies involving the rolandic region, carrying previously undescribed deletions in 16p13. The only gene located in the critical region shared by all three patients is GRIN2A coding for the alpha‐2 subunit of the neuronal N‐methyl‐d ‐aspartate (NMDA) receptor. 相似文献
994.
Ana Gracia Juan F. Martínez-Lage Juan-Luis Arsuaga Ignacio Martínez Carlos Lorenzo Miguel-Ángel Pérez-Espejo 《Child's nervous system》2010,26(6):723-727
Background
The authors report the morphological and neuroimaging findings of an immature human fossil (Cranium 14) diagnosed with left lambdoid synostosis. 相似文献995.
Pancreatic pseudocysts can be managed conservatively in the majority of patients but some of them will require surgical, endoscopic or percutaneous drainage. Endoscopic drainage represents an efficient modality of drainage with a high resolution rate and lower morbidity and mortality than the surgical or percutaneous approach. In this article we review the endoscopic pseudocyst drainage procedure with special emphasis on technical details. 相似文献
996.
Gregorio González-Alcaidea Rafael Aleixandre-Benavent José Ignacio De Granda-Orive 《Archivos de bronconeumologia》2010,46(2):78-84
IntroductionScientific cooperation is essential for the advance of biomedical research. Scientists set up informal groups to work together on common issues, who are the main units in the research funding system. Bibliometric and Social Network Analysis methods allow informal groups in scientific papers to be identified and characterised. The objective of the study is to identify research groups in Archivos de Bronconeumología between 2003 and 2007 period with the aim of characterizing their scientific collaboration patterns and research areas.MethodsCo-authorships, institutional collaboration relationships and the main research areas of papers published in Archivos de Bronconeumología have been identified. Co-authorship networks and institutional collaboration networks have been constructed by using Pajek software tool.ResultsA total of 41 research groups involving 171 investigators have been identified. The Collaboration Index for articles was 5.59 and the Transcience Index was 73.11%. There was institutional collaboration in 60.33% of papers. The collaboration between institutions of the same region prevails (41.03%), followed by collaborations between departments, services or units of the same institution (39.74%), inter-regional collaboration (14,97%) and international collaboration (6.83%). A total of 83.03% of articles were cited. The main research areas covered by groups were chronic obstructive pulmonary disease, asthma, lung neoplasm, bronchogenic carcinoma, smoking and pulmonary embolism.ConclusionsThe scientific production of a large number of Respiratory System Spanish research groups is published in Archivos de Bronconeumología. A notable collaboration and citation rate has been observed. Nevertheless, it is still essential to encourage inter-regional and international collaboration. 相似文献
997.
Moussalli MJ Wu Y Zuo X Yang XL Wistuba II Raso MG Morris JS Bowser JL Minna JD Lotan R Shureiqi I 《Cancer prevention research (Philadelphia, Pa.)》2011,4(12):1961-1972
Loss of terminal cell differentiation promotes tumorigenesis. 15-Lipoxygenase-1 (15-LOX-1) contributes to terminal cell differentiation in normal cells. The mechanistic significance of 15-LOX-1 expression loss in human cancers to terminal cell differentiation suppression is unknown. In a screen of 128 cancer cell lines representing more than 20 types of human cancer, we found that 15-LOX-1 mRNA expression levels were markedly lower than levels in terminally differentiated cells. Relative expression levels of 15-LOX-1 (relative to the level in terminally differentiated primary normal human-derived bronchial epithelial cells) were lower in 79% of the screened cancer cell lines than relative expression levels of p16 (INK4A), which promotes terminal cell differentiation and is considered one of the most commonly lost tumor suppressor genes in cancer cells. 15-LOX-1 was expressed during terminal differentiation in three-dimensional air-liquid interface cultures, and 15-LOX-1 expression and terminal differentiation occurred in immortalized nontransformed bronchial epithelial but not in lung cancer cell lines. 15-LOX-1 expression levels were lower in human tumors than in paired normal lung epithelia. Short hairpin RNA-mediated downregulation of 15-LOX-1 in Caco-2 cells blocked enterocyte-like differentiation, disrupted tight junction formation, and blocked E-cadherin and ZO-1 localization to the cell wall membrane. 15-LOX-1 episomal expression in Caco-2 and HT-29 colon cancer cells induced differentiation. Our findings indicate that 15-LOX-1 downregulation in cancer cells is an important mechanism for terminal cell differentiation dysregulation and support the potential therapeutic utility of 15-LOX-1 reexpression to inhibit tumorigenesis. 相似文献
998.
Amelia Guadalupe-Grau Ignacio Ara Cecilia Dorado German Vicente-Rodríguez Jorge Perez-Gomez Javier Chavarren Cabrero José A. Serrano-Sanchez Alfredo Santana Jose A. L. Calbet 《European journal of applied physiology》2010,110(3):635-643
Osteocalcin is a hormone produced by osteoblasts which acts as a negative regulator of fat mass, protecting against diet induced
obesity and insulin resistance in rodents. To determine if an acute increase in osteocalcin concentration is associated with
opposed changes in circulating leptin levels and insulin resistance we studied 15 middle and long distance male triathletes,
(age 32.1 ± 6.9 years), before and 48 h after an Olympic (OT) or an Ironman (IT) triathlon competition. Muscle power, anaerobic
capacity, body composition (dual-energy X-ray absorptiometry), and serum concentrations of testosterone, dihydrotestosterone,
osteocalcin, leptin, glucose, insulin and insulin resistance (HOMA) were determined pre- and post-race. Pre- and 48 h post-race
total and regional lean body mass was not altered, but fat mass was similarly increased (~250 g) 48 h after the competitions.
This elicited an increase in plasma leptin of 33% after the IT while it remained unchanged after the OT, likely due to a 25%
increase in plasma osteocalcin which occurred only after the OT (all p < 0.05). Post-race HOMA remained unchanged in OT and IT. Performance was normalized 48 h after the competitions, with the
exception of a slightly lower jumping capacity after the IT. Serum testosterone concentration tended to decrease by 10% after
the IT whilst dihydrotestosterone was reduced by 24% after the IT. In conclusion, an acute increase in serum osteocalcin concentration
blunts the expected increase of serum leptin concentration that should occur with fat mass gain. This study provides evidence
for osteocalcin as a negative regulator of serum leptin in humans. 相似文献
999.
1000.
Kim WY Prudkin L Feng L Kim ES Hennessy B Lee JS Lee JJ Glisson B Lippman SM Wistuba II Hong WK Lee HY 《Cancer》2012,118(16):3993-4003