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991.
992.
Matthias Knefel Brigitte Lueger-Schuster Jonathan Bisson Thanos Karatzias Evaldas Kazlauskas Neil P. Roberts 《Journal of traumatic stress》2020,33(1):41-51
The 11th revision of the World Health Organization's International Classification of Diseases (ICD-11) includes a new disorder, complex posttraumatic stress disorder (CPTSD). The network approach to psychopathology enables investigation of the structure of disorders at the symptom level, which allows for analysis of direct symptom interactions. The network structure of ICD-11 CPTSD has not yet been studied, and it remains unclear whether similar networks replicate across different samples. We investigated the network models of four different trauma samples that included a total of 879 participants (M age = 47.17 years, SD = 11.92; 59.04% women) drawn from Austria, Lithuania, and Scotland and Wales in the United Kingdom. The International Trauma Questionnaire was used to assess symptoms of ICD-11 CPTSD in all samples. The prevalence of PTSD and CPTSD ranged from 23.7% to 37.3% and from 9.3% to 53.1%, respectively. Regularized partial correlation networks were estimated and the resulting networks compared. Despite several differences in the symptom presentation and cultural background, the networks across the four samples were considerably similar, with high correlations between symptom profiles (ρs = .48–.87), network structures (ρs = .69–.75), and centrality estimates (ρs = .59–.82). These results support the replicability of CPTSD network models across different samples and provide further evidence about the robust structure of CPTSD. The most central symptom in all four sample-specific networks and the overall network was “feelings of worthlessness.” Implications of the network approach in research and practice are discussed. 相似文献
993.
Ilaria Xausa Robert Baier Olivier Bokanowski Matthias Gerdts 《Optimal control applications & methods.》2020,41(2):668-689
We consider the problem of computing safety regions, modeled as nonconvex backward reachable sets, for a nonlinear car collision avoidance model with time-dependent obstacles. The Hamilton-Jacobi-Bellman framework is used. A new formulation of level set functions for obstacle avoidance is given, and sufficient conditions for granting the obstacle avoidance on the whole time interval are obtained even though the conditions are checked only at discrete times. Different scenarios, including various road configurations, different geometry of vehicle and obstacles, as well as fixed or moving obstacles, are then studied and computed. Computations involve solving nonlinear partial differential equations of up to five space dimensions plus time with nonsmooth obstacle representations, and an efficient solver is used to this end. A comparison with a direct optimal control approach is also done for one of the examples. 相似文献
994.
Jasmin Hasmik Shahinian Eva A. Rog-Zielinska Manuel Schlimpert Bettina Mayer Stefan Tholen Bernd Kammerer Martin L. Biniossek Friedhelm Beyersdorf Oliver Schilling Matthias Siepe 《Artificial organs》2020,44(3):257-267
The changes in the myocardial proteome and metabolome associated with left ventricular assist device (LVAD) therapy in patients with ischemic cardiomyopathy (ICM) are poorly characterized. We investigated the impact of mechanical unloading following LVAD therapy on the myocardial proteome and metabolome. Matched samples of 5 patients’ myocardial tissue, harvested at the time of LVAD implant (“pre-LVAD”) or heart transplant (“post-LVAD”), were studied by quantitative proteomics and metabolomics as well as being probed for T-tubule structure and connexin-43 distribution. Moreover, pre-LVAD proteome profiles of ICM context were bioinformatically compared to pre-LVAD proteome profiles of dilated cardiac myopathy (DCM). More than 2120 proteins were reliably identified and quantified in paired patient samples. LVAD therapy led to proteomic remodeling, including reduced levels of α-1-antichymotrypsin together with an overall decrease of immune response proteins and an increase of proteins involved in membrane biology. Metabolomics highlighted increased glucose and glucose-6-phosphate levels in the left ventricle upon LVAD therapy. Wheat germ agglutinin staining demonstrated improved T-tubule structure. Connexin-43 displayed a trend for more pronounced intercalated disc localization. In comparing pre-LVAD proteome profiles of ICM context with pre-LVAD proteome profiles of dilated cardiac myopathy (DCM), we noticed an overrepresentation in ICM of proteins associated with humoral immune response. Our findings underline an impact of LVAD therapy on left ventricular biology in ICM. The proteomic, metabolomic, and structural alterations described here are typically associated with cardiac recovery. On the molecular level, our findings indicate the possibility of cardiac remodeling under LVAD therapy in ICM. 相似文献
995.
Kiss Norbert Fésűs Luca Bozsányi Szabolcs Szeri Flóra Van Gils Matthias Szabó Viktória Nagy Anikó Ilona Hidvégi Bernadett Szipőcs Róbert Martin Ludovic Vanakker Olivier Arányi Tamás Merkely Béla Wikonkál Norbert M. Medvecz Márta 《Lasers in medical science》2020,35(8):1821-1830
Lasers in Medical Science - Pseudoxanthoma elasticum (PXE, OMIM 264800) is a rare autosomal recessive disorder with ectopic mineralization and fragmentation of elastin fibers. It is caused by... 相似文献
996.
Goncalves Fernanda A. de Jesus Jessica Santos Cordeiro Lilian Piraciaba Maria Clara T. de Araujo Luiza K. R. P. Steller Wagner Martins Carolina Dalboni Maria Aparecida Pereira Benedito J. Silva Bruno C. Moysés Rosa Maria A. Abensur Hugo Elias Rosilene M. 《International urology and nephrology》2020,52(2):393-398
International Urology and Nephrology - Hypokalemia is a well-described electrolyte disturbance in patients on peritoneal dialysis (PD). Hyperkalemia, however, is still overlooked, although it also... 相似文献
997.
Matthias Mehdorn Stefan Niebisch Uwe Scheuermann Ines Gockel 《Acta chirurgica Belgica》2020,120(4):250-256
AbstractPurpose: There is evidence from various surgical specialties that incisional negative pressure wound therapy (iNPWT) might reduce postoperative surgical site infections (SSIs). In visceral and general surgery, there is varying evidence of its efficacy in reducing surgical site infections.Methods: A prospectively registered patient cohort of 43 patients with abdominal wall and visceral surgery received treatment with iNPWT and was compared to a matched retrospective cohort to analyze its effects on SSI occurrence and respective risk factors. Groups were matched by procedure, sex, body mass index and age. We used two different systems of iNPWT: (i) PREVENATM or (ii) self-made epicutaneous iNPWT from common VAC material.Results: We could not find a total reduction in postoperative SSIs by application of iNPWT. But within the iNPWT cohort, patients with self-made iNPWT suffered more often from SSIs compared to the commercial iNPWT subgroup. No patient specific risk factors could be identified to advocate the use of iNPWT.Conclusion: Our data do not support the use of an incisional negative pressure wound therapy on closed wounds in midline laparotomy incisions. Although, differences exist between the commmercial and self-made systems. 相似文献
998.
Wolfgang Kemmler Matthias Kohl Michael Fröhlich Franz Jakob Klaus Engelke Simon von Stengel Daniel Schoene 《Journal of bone and mineral research》2020,35(9):1634-1644
Dynamic resistance exercise (DRT) might be the most promising agent for fighting sarcopenia in older people. However, the positive effect of DRT on osteopenia/osteoporosis in men has still to be confirmed. To evaluate the effect of low-volume/high-intensity (HIT)-DRT on bone mineral density (BMD) and skeletal muscle mass index (SMI) in men with osteosarcopenia, we initiated the Franconian Osteopenia and Sarcopenia Trial (FrOST). Forty-three sedentary community-dwelling older men (aged 73 to 91 years) with osteopenia/osteoporosis and SMI-based sarcopenia were randomly assigned to a HIT-RT exercise group (EG; n = 21) or a control group (CG; n = 22). HIT-RT provided a progressive, periodized single-set DRT on machines with high intensity, effort, and velocity twice a week, while CG maintained their lifestyle. Both groups were adequately supplemented with whey protein, vitamin D, and calcium. Primary study endpoint was integral lumbar spine (LS) BMD as determined by quantitative computed tomography. Core secondary study endpoint was SMI as determined by dual-energy X-ray absorptiometry. Additional study endpoints were BMD at the total hip and maximum isokinetic hip−/leg-extensor strength (leg press). After 12 months of exercise, LS-BMD was maintained in the EG and decreased significantly in the CG, resulting in significant between-group differences (p < 0.001; standardized mean difference [SMD] = 0.90). In parallel, SMI increased significantly in the EG and decreased significantly in the CG (p < 0.001; SMD = 1.95). Total hip BMD changes did not differ significantly between the groups (p = 0.064; SMD = 0.65), whereas changes in maximum hip−/leg-extensor strength were much more prominent (p < 0.001; SMD = 1.92) in the EG. Considering dropout (n = 2), attendance rate (95%), and unintended side effects/injuries (n = 0), we believe our HIT-RT protocol to be feasible, attractive, and safe. In summary, we conclude that our combined low-threshold HIT-RT/protein/vitamin D/calcium intervention was feasible, safe, and effective for tackling sarcopenia and osteopenia/osteoporosis in older men with osteosarcopenia. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research. 相似文献
999.
SMASH, SENSE, PILS, GRAPPA: how to choose the optimal method 总被引:8,自引:0,他引:8
Blaimer M Breuer F Mueller M Heidemann RM Griswold MA Jakob PM 《Topics in magnetic resonance imaging : TMRI》2004,15(4):223-236
Fast imaging methods and the availability of required hardware for magnetic resonance tomography (MRT) have significantly reduced acquisition times from about an hour down to several minutes or seconds. With this development over the last 20 years, magnetic resonance imaging (MRI) has become one of the most important instruments in clinical diagnosis. In recent years, the greatest progress in further increasing imaging speed has been the development of parallel MRI (pMRI). Within the last 3 years, parallel imaging methods have become commercially available, and therefore are now available for a broad clinical use. The basic feature of pMRI is a scan time reduction, applicable to nearly any available MRI method, while maintaining the contrast behavior without requiring higher gradient system performance. Because of its faster image acquisition, pMRI can in some cases even significantly improve image quality. In the last 10 years of pMRI development, several different pMRI reconstruction methods have been set up which partially differ in their philosophy, in the mode of reconstruction as well in their advantages and drawbacks with regard to a successful image reconstruction. In this review, a brief overview is given on the advantages and disadvantages of present pMRI methods in clinical applications, and examples from different daily clinical applications are shown. 相似文献
1000.
Max J. Friedrich Jan Schmolders Robert D. Michel Thomas M. Randau Matthias D. Wimmer Hendrik Kohlhof Dieter C. Wirtz Sascha Gravius 《International orthopaedics》2014,38(12):2455-2461