全文获取类型
收费全文 | 27458篇 |
免费 | 1749篇 |
国内免费 | 133篇 |
专业分类
耳鼻咽喉 | 250篇 |
儿科学 | 681篇 |
妇产科学 | 411篇 |
基础医学 | 3952篇 |
口腔科学 | 1061篇 |
临床医学 | 2531篇 |
内科学 | 5865篇 |
皮肤病学 | 738篇 |
神经病学 | 2873篇 |
特种医学 | 1451篇 |
外科学 | 4164篇 |
综合类 | 134篇 |
一般理论 | 10篇 |
预防医学 | 1408篇 |
眼科学 | 557篇 |
药学 | 1479篇 |
中国医学 | 75篇 |
肿瘤学 | 1700篇 |
出版年
2023年 | 180篇 |
2022年 | 356篇 |
2021年 | 784篇 |
2020年 | 489篇 |
2019年 | 631篇 |
2018年 | 794篇 |
2017年 | 614篇 |
2016年 | 843篇 |
2015年 | 936篇 |
2014年 | 1082篇 |
2013年 | 1418篇 |
2012年 | 2197篇 |
2011年 | 2101篇 |
2010年 | 1284篇 |
2009年 | 1149篇 |
2008年 | 1845篇 |
2007年 | 1970篇 |
2006年 | 1778篇 |
2005年 | 1669篇 |
2004年 | 1537篇 |
2003年 | 1352篇 |
2002年 | 1233篇 |
2001年 | 265篇 |
2000年 | 175篇 |
1999年 | 256篇 |
1998年 | 226篇 |
1997年 | 209篇 |
1996年 | 142篇 |
1995年 | 103篇 |
1994年 | 84篇 |
1993年 | 110篇 |
1992年 | 111篇 |
1991年 | 76篇 |
1990年 | 78篇 |
1989年 | 76篇 |
1988年 | 66篇 |
1987年 | 52篇 |
1986年 | 23篇 |
1985年 | 41篇 |
1984年 | 38篇 |
1983年 | 33篇 |
1982年 | 40篇 |
1981年 | 27篇 |
1980年 | 38篇 |
1978年 | 22篇 |
1977年 | 25篇 |
1976年 | 24篇 |
1975年 | 25篇 |
1973年 | 27篇 |
1931年 | 24篇 |
排序方式: 共有10000条查询结果,搜索用时 484 毫秒
31.
32.
33.
Gastroesophageal reflux disease (GERD) is a common disease and can be successfully treated by laparoscopic fundoplication.
This article describes the technique of laparoscopic surgery for GERD with a focus on operative pitfalls. 相似文献
34.
Davangere P Devanand Christian G Habeck Matthias H Tabert Nikolaos Scarmeas Gregory H Pelton James R Moeller Brett D Mensh Tyler Tarabula Ronald L Van Heertum Yaakov Stern 《Neuropsychopharmacology》2006,31(6):1327-1334
Temporoparietal and posterior cingulate metabolism deficits characterize patients with Alzheimer's disease (AD). A H(2)(15)O resting PET scan covariance pattern, derived by using multivariate techniques, was previously shown to discriminate 17 mild AD patients from 16 healthy controls. This AD covariance pattern revealed hypoperfusion in bilateral inferior parietal lobule and cingulate; and left middle frontal, inferior frontal, precentral, and supramarginal gyri. The AD pattern also revealed hyperperfusion in bilateral insula, lingual gyri, and cuneus; left fusiform and superior occipital gyri; and right parahippocampal gyrus and pulvinar. In an independent sample of 23 outpatients with mild cognitive impairment (MCI) followed at 6-month intervals, the AD pattern score was evaluated as a predictor of cognitive decline. In this MCI sample, an H2(15)O resting PET scan was carried out at baseline. Mean duration of follow-up was 48.8 (SD 15.5) months, during which time six of 23 MCI patients converted to AD. In generalized estimating equations (GEE) analyses, controlling for age, sex, education, and baseline neuropsychological scores, increased AD pattern score was associated with greater decline in each neuropsychological test score over time (Mini Mental State Exam, Selective Reminding Test delayed recall, Animal Naming, WAIS-R digit symbol; Ps<0.01-0.001). In summary, a resting PET covariance pattern previously reported to discriminate AD patients from control subjects was applied prospectively to an independent sample of MCI patients and found to predict cognitive decline. Independent replication in larger samples is needed before clinical application can be considered. 相似文献
35.
Synergistic effect of low dose Cyclosporine A and human interleukin 10 overexpression on acute rejection in rat lung allotransplantation 总被引:3,自引:0,他引:3
Jaroslaw Pierog Amiq Gazdhar Uz Stammberger Matthias Gugger Steven Hyde Iacob Mathiesen Tomasz Grodzki Ralph A. Schmid 《European journal of cardio-thoracic surgery》2005,27(6):1030-1035
Objective: Electroporation mediated transfer of plasmid DNA into peripheral muscle results in high transfection efficiency. The aim of this study was to investigate the effect of gene transfer of human IL-10 (hIL-10) into the tibialis anterior muscle (MTA) in combination with low dose Cyclosporine A (CsA) on acute rejection of lung allografts in the rat. Methods: Lung allotransplantation was performed from male BN donor to male Fisher F344 rats. Gene transfer was achieved by intramuscular injection into the MTA of the recipient followed by electroporation (4×20 ms impulses at 200 V/cm) 24 h prior to the transplantation. Group A (n=5) received CsA (2.5 mg/kg bw ip) for 5 days post-transplant and group B (n=5) 2.5 μg of PCIK hIL-10 (plasmid expression vector containing human CMV immediate early gene promoter and enhancer) and a low dose CsA (2.5 mg/kg bw i.p.). Graft function was assessed by blood gas at day 5 after exclusion of the native lung. Animals were sacrificed and blood was drawn to measure serum hIL-10 levels (ELISA) and tissue was sampled for histological grading of rejection. Results: Local expression of hIL-10 was confirmed at the mRNA level by in situ hybridization. All group A control animals showed severe signs of rejection. At day 5 all grafts in group B showed good gas exchange mean PaO2 233±123 mmHg, vs 44±8 mmHg in group A. Histological examination revealed moderate to severe rejection in all animals in group A (IIIB, ISHLT) in contrast to low moderate rejection in group B (II–IIIA). hIL-10 serum levels on day 5 were 14±7 pg/ml in group B vs. 0 in group A. Conclusions: Electroporation mediated hIL-10 overexpression in a peripheral muscle of the recipient in combination with low dose CsA reduces acute rejection in this model of rat lung allotransplantation. 相似文献
36.
Jean-Michel Halimi Inass Laouad Matthias Buchler Azmi Al-Najjar Valérie Chatelet Tarik Sqalli Houssaini Hubert Nivet Yvon Lebranchu 《American journal of transplantation》2005,5(9):2281-2288
Proteinuria 1 year after transplantation is associated with poor renal outcome. It is unclear whether low-grade (<1 g/24 h) proteinuria earlier after transplantation and its short-term change affect long-term graft survival. The effects of proteinuria and its change on long-term graft survival were retrospectively assessed in 484 renal transplant recipients. One- and 3-month proteinuria correlated with donor age, donor cardiovascular death, prolonged cold and warm ischemia times and acute rejection. One- and 3-month proteinuria (per 0.1 g/24 h, hazard ratio (HR): 1.07 and 1.15, p<0.0001)-especially low-grade proteinuria (HR: 1.20 and 1.26, p<0.0001)-were powerful, independent predictors of graft loss. Its short-term reduction correlated with arterial pressure (AP) (the lower the 3-month diastolic and 12-month systolic AP, the lower the risk of increasing proteinuria during 1-3 months and 3-12 months periods, respectively: Odds ratio (OR) per 10 MmHg: 0.78, p=0.01 and 0.85, respectively, p=0.02), and was associated with decreased long-term graft loss (per 0.1 g/24 h: HR: 0.88 and 0.98, respectively, p<0.0001), independently of initial proteinuria. Early low-grade proteinuria due to pre-transplant renal lesions, ischemia-reperfusion and immunologic injuries is a potent predictor of graft loss. Short-term reduction in proteinuria is associated with improved long-term graft survival. 相似文献
37.
Radiofrequency-ablation of unresectable primary and secondary liver tumors: results in 88 patients 总被引:5,自引:0,他引:5
Philipp Hildebrand Markus Kleemann Uwe J. Roblick Lutz Mirow Matthias Birth Thorsten Leibecke Hans-Peter Bruch 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2006,391(2):118-123
Background and aims Radiofrequency-ablation (RFA) is increasingly used for destruction of unresectable primary and secondary liver tumors. We
report our experience in the use of RFA for the management of unresectable hepatic malignancies.
Patients and methods Between February 2000 and December 2004 we have undertaken 120 RFA procedures to ablate 426 unresectable primary or metastatic
liver tumors in 88 patients. RFA was performed via laparotomy (n=68), laparoscopy (n=9) or a percutaneous approach (n=43). Primary liver cancer was treated in seven patients (8%) and metastatic liver tumors were treated in 81 patients (92%).
All patients were followed to assess complications, treatment response and recurrence of malignant disease.
Results Procedure-related complication rate was low (3.4%). During a mean follow-up of 21.2 months, 15 patients had local tumor progression
(17%), 21 patients (23,9%) had new malignant disease and 27 patients (30.7%) died from intervention-unrelated complications
of their malignant disease. Additional liver lesions were identified in 27 (35%) of 77 cases by intraoperative ultrasound.
Thirty-six patients received simultaneous resection and RFA.
Conclusion RFA is a safe, well-tolerated and effective treatment for patients with unresectable primary and secondary liver malignancies. 相似文献
38.
39.
40.