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71.
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Damon E. Houghton Insu Koh Alicia Ellis Nigel S. Key Daniel R. Douce George Howard Mary Cushman Monika Safford Neil A. Zakai 《American journal of hematology》2020,95(3):258-266
Higher and lower hemoglobin concentrations are associated with coronary heart disease (CHD), but whether this risk is consistent across age, sex, and race is unclear. The Reasons for Geographic And Racial Differences in Stroke (REGARDS) study is an observational cohort study of 30 239 black, and white, adults aged 45 and older recruited 2003-7. Participants were included if they had hemoglobin measures, were CHD-free at baseline, and had all baseline variables. The primary outcome was incident CHD. Multivariable Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for incident CHD by hemoglobin concentration. This was expressed as a continuous variable and divided into age-, sex-, and race-specific quintiles. The 16 332 participants were included, contributing 114 362 person-years of follow-up and 915 incident CHD events. The mean age was 63 years, 35% were male, 41% were black, and the mean baseline hemoglobin was 13.6 g/dL (SD 1.4). A significant non-linear association between hemoglobin and CHD was identified (P < .001). This association differed significantly by race (P = .025) but not by sex or age. In whites, the risk for incident CHD was higher in the lowest (HR 2.28, 95% CI 1.61, 3.33) and highest (HR 1.94, 95% CI 1.35, 2.79) hemoglobin quintiles relative to the third quintile. For blacks, only those in the lowest hemoglobin quintile had an increased risk for incident CHD events (HR 1.70, 95% CI 1.20, 2.41). Hemoglobin is an independent risk factor for CHD in whites and blacks but with different hemoglobin concentrations conferring different risks. 相似文献
73.
Damon E. Houghton Ana I. Casanegra Lisa G. Peterson Jordan Cochuyt David O. Hodge Danielle Vlazny Robert D. McBane David Froehling Waldemar E. Wysokinski 《American journal of hematology》2020,95(7):817-823
Randomized controlled trials leading to the approval of apixaban and rivaroxaban for venous thromboembolism (VTE) did not include patients with upper extremity deep vein thrombosis (UE-DVT). We sought to evaluate the safety and effectiveness of rivaroxaban and apixaban for the treatment of acute UE-DVT. Consecutive patients with VTE enrolled into the Mayo Clinic VTE Registry, between March 1, 2013 and December 31, 2019, were followed prospectively. Clinical, demographic and imaging data were collected at the time of study recruitment. Patients with a diagnosis of acute UE-DVT who received rivaroxaban, apixaban, LMWH or warfarin were included. Recurrent VTE, major bleeding, clinical-relevant non-major bleeding (CRNMB), and death were assessed at 3-month intervals. During the study period, 210 patients with acute UE-DVT were included; 63 were treated with apixaban, 39 with rivaroxaban, and 108 with LWMH and/or warfarin. Overall 51% had catheter-associated UE-DVT, 60% had a diagnosis of malignancy, and 14% had concurrent pulmonary embolism. Malignancy was more common in patients treated with LMWH/warfarin (67% vs 52%, P = .03). At 3 months of follow up, one (0.9%) recurrent VTE occurred in a patient treated with LMWH/warfarin and one (1.0%) patient treated with apixaban or rivaroxaban (P = .97). Major bleeding occurred in three patients treated with LMWH/warfarin, and in none of those treated with apixaban or rivaroxaban (P = .09). Clinical-relevant non-major bleeding occurred in one patient (0.9%) treated with LWMH/warfarin and two patients (2.0%) treated with apixaban or rivaroxaban (P = .53). Treatment of UE-DVT with apixaban or rivaroxaban appears to be as safe and effective as LMWH/warfarin. 相似文献
74.
Houghton Damon E. Lekah Alexander Macedo Thanila A. Hodge David Saadiq Rayya A. Little Yvonne Casanegra Ana I. McBane Robert D. Wysokinski Waldemar E. 《Journal of thrombosis and thrombolysis》2020,49(2):199-205
Journal of Thrombosis and Thrombolysis - Thrombosis resolution is an important component of treatment for deep vein thrombosis (DVT) and multiple anticoagulants are now available. It is unknown... 相似文献
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Maryam Fouladi MD John P. Perentesis MD Christine L. Phillips MD Sarah Leary MD Joel M. Reid PharmD Renee M. McGovern Ashish M. Ingle MSc Charlotte H. Ahern PhD Matthew M. Ames PharmD Peter Houghton PhD L. Austin Doyle MD Brenda Weigel MD Susan M. Blaney MD 《Pediatric blood & cancer》2014,61(7):1246-1251
77.
Katie Nightingale Martin Potts Leah M. Hunter Ceri A. Fielding Cassie M. Zerbe Alice Fletcher-Etherington Luis Nobre Eddie C. Y. Wang Blair L. Strang Jack W. Houghton Robin Antrobus Nicolas M. Suarez Jenna Nichols Andrew J. Davison Richard J. Stanton Michael P. Weekes 《Proceedings of the National Academy of Sciences of the United States of America》2022,119(6)
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80.
The biological activity of Valerian and related plants 总被引:4,自引:0,他引:4
P J Houghton 《Journal of ethnopharmacology》1988,22(2):121-142
A comprehensive review of the constituents of the Valerianaceae is presented with particular reference to the sedative activity of extracts from various constituent species. The sedative activity can be ascribed to the valepotriates present and to a lesser extent to the sesquiterpene constituents of the volatile oils. Recent research into the toxicology of the valepotriates is also considered. 相似文献