Adrenal gland volume after spinal cord injury

OBJECTIVE: Spinal cord injury in adult men may result in hypothalamic-pituitary-adrenal axis dysfunction. Atrophy of adrenal glands was speculated in these patients. This study was undertaken to clarify the functional-anatomic correlation between adrenal volume and body surface area in subjects with spinal cord injury with impaired adrenal reserve. DESIGN: Twenty male subjects with chronic spinal cord injury with impaired adrenal reserve were identified by adrenocorticotropic hormone stimulation test from a group of 42 subjects. All subjects with spinal cord injury and healthy volunteers underwent computed tomographic imaging with contiguous 3-mm section over adrenal glands for volumetric measurements. Ten pairs of subjects with spinal cord injury and controls with matched height and weight were included in the statistical analysis. RESULTS: Significantly increased relative adrenal volumes were noted among subjects with chronic spinal cord injury and impaired adrenal reserve as compared with the body weight-matched and height-matched control group. CONCLUSIONS: Increased relative adrenal volumes were found after chronic spinal cord injury. Hyperplasia of the zona glomerulosa may be the cause of increased relative adrenal volume after chronic spinal cord injury.     

硝苯地平与银杏黄酮的体外代谢性相互作用

 目的通过体外代谢获得药物相互作用的有关数据,以预测临床联合用药时发生代谢性药物相互作用的可能性。方法以HPLC测定孵育液中剩余银杏黄酮的浓度,计算共孵育药物硝苯地平对银杏黄酮3个苷元的IC₅₀值和K_i值;以HPLC测定孵育液中硝苯地平的浓度,计算其代谢抑制率。结果硝苯地平与银杏黄酮进行体外共孵育时,代谢互受影响。结论两药合用时宜慎重。     

Gefitinib treatment for non-small cell lung cancer -- a study including patients with poor performance status.

BACKGROUND AND PURPOSE: Gefitinib is effective in the treatment of advanced non-small cell lung cancer (NSCLC). However, most studies have only investigated patients who have good performance status or are evaluable. This study evaluated the efficacy of geftinib in a consecutive series of patients with NSCLC. METHODS: The treatment response of all gefitinib-treated NSCLC patients from November 2001 to September 2003 at a single medical institute was retrospectively evaluated. All patients receiving at least 1 dose of gefitinib during the study period were included. RESULTS: A total of 66 NSCLC patients were treated, including 22 patients with Eastern Clinical Oncology Group performance status 3 or 4. No prior chemotherapy had been given in 14 patients because of their personal preference or poor general condition. The duration of treatment ranged from 1 day to 19.3 months (median, 2.5 months). The partial remission rate was 15.2% and the stable disease rate was 25.8%. The median survival for all patients was 5.9 months and the 1-year survival rate was 27.9%. Symptom improvement and response correlated well to survival. Female gender, non-smoking status, and performance status of 0-2 were associated with better survival. The disease control rate was 22.7% in patients with performance status of 3-4. CONCLUSIONS: Gefitinib can be recommended for the treatment of advanced NSCLC in patients for whom standard chemotherapy is not an option. Further study is required to determine the optimal selection criteria of patients and the timing of starting therapy.     

长期低硒仔四代哺乳期大鼠神经行为发育的观察

目的研究长期低硒和低硒低碘膳食对大鼠生长发育及神经行为发育的影响。方法建立人工膳食性硒缺乏和硒碘联合缺乏动物模型,分为补硒补碘组(对照组)、低硒组、低碘组和低硒低碘组四组,繁殖传代至第4代仔鼠,并对各组哺乳期仔4代大鼠进行生理发育及神经行为发育指标的检测。结果第3代母鼠中低硒组和低碘组受孕率(70%,88%)低于对照组和低硒低碘组(100%,P<0.01),低硒组(28.6%)、低碘组和低硒低碘组(10.5%)流产率均明显高于对照组(0.00,P<0.01)。第4代仔鼠中对照组4d存活率(86.3%)高于其他3组(P<0.01),低硒组和低硒低碘组仔鼠生理发育、新生反射和感觉功能及神经肌肉发育成熟状况等方面各指标中均有50%以上出现明显发育延迟,差异具有显著性(P<0.01),低碘组大鼠耳廓分离率、睁眼率及前肢握力评分亦差于对照组(P<0.05)。结论单纯低硒、低碘及硒碘水平同时降低,可以导致仔4代大鼠生长发育延迟及神经行为异常。     

护理专业班级管理应注重学生团队精神的培养

团队精神是护士基本素质之一。但当代的护生,由于其成长环境和生活条件的时代特殊性,团队精神比较缺乏。因此,护理专业的班主任在班级管理过程中,可通过以下途径和方法,加强学生团队精神的培养:加强护理专业思想教育,培养学生的敬业精神;班级管理实行班团干部负责制,培养学生的责任心;妥善解决学生间的矛盾,培养学生宽容与相互信任的品质;开展以小组为单位的竞赛活动,培养学生的全局观念;帮助学生获得班级荣誉,培养学生的团队自豪感。     

脂联素与2型糖尿病及心血管病变的研究进展

研究认为脂联素在2型糖尿病胰岛素抵抗、心血管病中起着特别重要的作用.脂联素与2型糖尿病及心血管病变的研究可为揭示胰岛素抵抗的病因、胰岛素抵抗的相关疾病的诊断治疗提供有价值的参考信息。     

子宫内膜癌54例临床分析

目的 探讨子宫内膜癌手术加辅助治疗的疗效和价值。方法 回顾性分析行手术和辅助治疗的54例子宫内膜癌的临床和病理资料．其中，单纯手术治疗10例，手术加辅助治疗44例。手术方法以扩大及次广泛子宫切除＋双附件切除术为主．辅以激素治疗、放疗及化疗，对所有病例进行追踪随访。结果 生命表统计1，3，5年生存率分别为98．15％．92．59％，81．48％。比较子宫内膜癌Ⅰ期与Ⅱ期、Ⅲ期患者的生存率，1年生存率两者无差异，3年生存率Ⅰ期高于Ⅱ期、Ⅲ期患者。结论 子宫内膜癌的手术加辅助治疗能达到满意的临床疗效。     

16层螺旋CT三维重建技术在肋骨骨折中的临床应用

目的评价16层螺旋CT三维重建技术在肋骨骨折中的应用价值。方法对88例肋骨骨折患者进行16层螺旋CT扫描．重建全肋骨SSD图像。结果88例均经多层面重建术（multipianar reconstruction MPR）和表面遮盖法（surface shaded display．SSD）技术重建满意的显示出三维重建图像。MPR显示肋骨骨折300根．SSD显示290根。结论16层螺旋CT肋骨兰维重建能够直观、立体、清晰、多角度的显示肋骨骨折．具有较高的临床应用价值。     

祁门红茶抗氧化有效成分的研究

祁门红茶有较强的抗芥花子油氧化的活性.从祁门红茶乙酸乙酯部位,使用硅胶柱层析,结合Sephadex LH-20柱层析方法,分离得到了四个抗氧化有效成分,分别为茶黄素(Theaflavin,TF1)、茶黄素A(Theaflavin-3-galate,TF2A)、茶黄素B(Theaflavin-3'-gallate,TF2B)和茶黄素双没食子酸酯(Theaflavin digallate,TF3).