Increased levels of circulating fibroblast growth factor 21 in children with Kawasaki disease

Clinical and Experimental Medicine - The purpose of this study was to examine the serum levels of fibroblast growth factor 21 (FGF21) in children with acute Kawasaki disease (KD) and to investigate...     

初始耐药肺结核调查分析

目的掌握信宜市肺结核病人初始耐药疫情,分析耐药的原因,制定预防对策。方法以胸片、痰涂片诊断为肺结核的初治患者为对象,进行结核菌培养,阳性者做链霉素（S）、异烟肼（I）、利福平（R）、乙胺丁醇（E）四种药敏试验。结果共检测188例,初始耐药62例,占32．98％。其中耐1种药物51例,占耐药总数的82．26％;耐2种以上药物11例,占耐药总数的17．74％。41—50岁为耐药最高峰,四种耐药次序为I〉R〉S〉E。结论信宜市耐药肺结核疫情相当严峻,应进一步分析耐药原因,探讨预防对策。     

The nationwide distribution and trends of hepatitis C virus genotypes in mainland China

Comprehensive data on hepatitis C virus (HCV) genotypes distribution is critical for treatment regimen selection, vaccine design, and drug development. This study aimed to understand the dynamic distribution of HCV genotypes in Mainland China. Three hundred sixty-two studies published from January 1993 to December 2017 involving 64 891 samples (5133 injecting drug users, 2748 volunteer blood donors, 1509 former paid plasma donors, 160 sexually encounters, and 1992 human immunodeficiency virus (HIV)/HCV coinfection patients) were eligible for the quantitative synthesis estimation. Pooled proportion of HCV genotypes (and 95% confidence intervals [CIs]) was estimated through the Freeman-Tukey double arcsine transformation by period, region, and risk group. A sharp decline of the subtype 1b was observed in all regions except in northwestern and central regions. The genotypes 3 and 6 showed an obvious increase in southern and southwestern regions and have already spread nationwide. After 2010, subtype 1b was the most dominant variant in all regions and risk groups, accounting for 54.0% (95% CI, 51.9-56.1) of all national infections. Subtype 2a was the second most prevalent strain in all regions except in the south and southwest, with 15.4% (95% CI, 13.1-17.8) national infections. The subtype 6a in southern region and 3b and 3a in southwestern region had a higher proportion of infections than that in other regions. In addition, the genotypes 3 and 6 are already prevalent in almost all risk groups. The distribution of HCV genotypes were sharply shifting in China in the past three decades. The HCV subtype 1b posed a sharp decline, whereas genotypes 3 and 6 played an increasing role in the regional and populational HCV pandemic.     

Further confirmation of second- and third-generation Eimeria necatrix merozoite DEGs using suppression subtractive hybridization

Parasitology Research - In our previous study, we obtained a large number of differentially expressed genes (DEGs) between second-generation merozoites (MZ-2) and third-generation merozoites (MZ-3)...     

不同浓度氢氧化钙溶液对细菌内毒素降解作用的比较研究

目的 研究3种不同浓度的氢氧化钙溶液对细菌内毒素的降解作用.方法 选用E.coli标准内毒素稀释成10Eu/ml后分别与3种不同浓度的氢氧化钙溶液混合,37℃水浴,经60min、120min作用后采用动态浊度法鲎实验检测剩余内毒素浓度.结果 在相同作用时间内,氢氧化钙溶液浓度越高降解作用越强,结果有极显著性差异;同一种浓度氢氧化钙溶液作用时间越长其降解作用越强,结果有显著性差异.结论 氢氧化钙作为根管治疗药物具有降解G-菌内毒素的作用,此降解作用具有浓度和时间的依赖性.     

Raypex5根尖定位仪在测量根管工作长度中的临床应用

目的评价Raypex5根尖定位仪测量根管工作长度与X线法的符合性。方法用Raypex5根尖定位仪对205颗患牙共403个根管进行根管工作长度测量，以此长度进行根管预备充填后拍摄X线片观察根管充填的质量。结果Raypex5根尖定位仪测量根管工作长度后根管适充率为96．28％。结论Raypex5根尖定位仪是一种准确可靠安全有效根管工作长度测量仪器。     

MRI在口腔颌面部肿块诊断中的应用

作者对38例发生在口腔颌面部肿块患者采用MRI检诊。结合缅针穿吸缅胞学检查，并与CT扫描对比研究。结果提示：对口腔颌面部肿块。管状瘤或临床怀疑肿瘤有颅底、眶尖、翼腭窝、咽侧、颈部大血管神经累及者。MRI扫描成像清晰。软组织分辨率高。能早期发现骨质侵蚀。作者还对MRI在监测颌面部癌瘤切除术后局部是否复发进行初步观察。