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101.
Kanumuri Prathima Hayse Brandon Killelea Brigid K. Chagpar Anees B. Horowitz Nina R. Lannin Donald R. 《Annals of surgical oncology》2015,22(8):2475-2482
Annals of Surgical Oncology - Multifocality and multicentricity are increasingly recognized in breast cancer. However, little is known about the characteristics and biology of these cancers and the... 相似文献
102.
Michael Kassardjian Mayha Patel Paul Shitabata David Horowitz 《The Journal of clinical and aesthetic dermatology》2015,8(7):48-51
Granuloma annulare is a disease characterized by granulomatous inflammation of the dermis. Localized granuloma annulare may resolve spontaneously, while generalized granuloma annulare may persist for decades. The authors present the case of a 41-year-old Hispanic man with a two-week history of periocular granuloma annulare. Due to previously reported success in the use of systemic dapsone for the treatment of granuloma annulare, and the periocular proximity of the patient’s lesion, topical dapsone was used for treatment. Various additional therapies for the management of granuloma annulare have been reported, such as topical and systemic steroids, isotretinoin, pentoxifylline, cyclosporine, Interferon gamma, potassium iodide, nicotinamide, niacinamide, salicylic acid, fumaric acid ester, etanercept, infliximab, and hydroxychloroquine. Additional clinical trials are necessary to further evaluate the effectiveness of topical dapsone in the management of granuloma annulare.Granuloma annulare (GA) was first identified in 1985 by Fox1 and has since been well-described in the literature as benign, firm, skin-colored, and solitary or grouped papules or nodules arranged in an annular pattern.2 When the nodules increase in size the annular ring arrangement can become obscured.3 GA most commonly occurs in women in the first three decades of life.2 The estimated distribution of GA lesions per the literature is 60 percent on the hands or arms, 20 percent on the feet and legs, seven percent involving both upper and lower extremities, five percent on the trunk, and five percent involving any other areas, such as the face and scalp.4 It is rare to see GA on the face and scalp especially in adults as it usually occurs in children.3 There have however been some instances of GA occurring on the face in adults as reported by Coskey in 1979 who studied the literature and found 44 reported cases of facial GA of which 25 were adults.5 There are four subtypes of GA: localized, perforating, subcutaneous, and generalized.3 The most common subtype is localized GA, which occurs in children and presents clinically as small, firm, asymptomatic, skin-colored or red papules or nodules in an arciform pattern and is histologically consistent with no epidermal change. This type runs the course of enlargement and later regression.3 The second type is the perforating type, which appears as umbilicated lesions. The third type is subcutaneous GA, which appears clinically as subcutaneous nodules either mobile or fixed to the periosteum or bone located most commonly on the extremities.3 The fourth type is generalized/disseminated GA, which occurs primarily in adults and presents as widespread flesh-colored to violaceous papules or plaques. Although there is some controversy over this relationship, generalized GA has been accepted to be significantly associated with diabetes mellitus.3 相似文献
103.
Scott R. Spielman MD Ardeshir Farshidi MD FACC Leonard N. Horowitz MD FACC Mark E. Josephson MD FACC 《The American journal of cardiology》1978,42(6):913-918
Ventricular fibrillation occurred in 10 (3.3 percent) of 300 patients consecutively studied with programmed ventricular stimulation. One hundred twenty-five of these patients were studied with double ventricular extrastimuli including 68 patients with and 57 patients without documented or suspected ventricular tachycardia or fibrillation, or both. Ventricular fibrillation did not develop in response to a single ventricular extrastimulus delivered during sinus rhythm, ventricular pacing or ventricular tachycardia or in response to ventricular pacing at cycle lengths of 300 msec or greater and occurred only in response to double ventricular extrastimuli. All 10 patients who manifested ventricular fibrillation during programmed stimulation were in the group of patients with suspected or documented ventricular tachycardia or fibrillation. Ventricular fibrillation was initiated in seven patients with double ventricular extrastimuli delivered during sinus rhythm or ventricular pacing and in three patients with double ventricular extrastimuli delivered during ventricular tachycardia. Four patients had spontaneous conversion to sinus rhythm and the remainder underwent defibrillation without sequelae. Recurrent ventricular fibrillation occurred clinically in 7 of the 10 patients. This study suggests that ventricular fibrillation occurs uncommonly during programmed ventricular stimulation and only in response to double ventricular extrastimuli in patients in whom spontaneous episodes are likely to occur. 相似文献
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J Tang DJ Humes E Gemmil NT Welch SL Parsons JA Catton 《Annals of the Royal College of Surgeons of England》2013,95(5):323-328