全文获取类型
收费全文 | 4500篇 |
免费 | 236篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 145篇 |
妇产科学 | 31篇 |
基础医学 | 657篇 |
口腔科学 | 79篇 |
临床医学 | 256篇 |
内科学 | 1005篇 |
皮肤病学 | 47篇 |
神经病学 | 389篇 |
特种医学 | 251篇 |
外科学 | 814篇 |
综合类 | 11篇 |
预防医学 | 65篇 |
眼科学 | 28篇 |
药学 | 316篇 |
中国医学 | 25篇 |
肿瘤学 | 584篇 |
出版年
2023年 | 28篇 |
2022年 | 31篇 |
2021年 | 89篇 |
2020年 | 43篇 |
2019年 | 69篇 |
2018年 | 69篇 |
2017年 | 61篇 |
2016年 | 77篇 |
2015年 | 81篇 |
2014年 | 95篇 |
2013年 | 128篇 |
2012年 | 232篇 |
2011年 | 255篇 |
2010年 | 142篇 |
2009年 | 125篇 |
2008年 | 247篇 |
2007年 | 265篇 |
2006年 | 268篇 |
2005年 | 266篇 |
2004年 | 281篇 |
2003年 | 263篇 |
2002年 | 259篇 |
2001年 | 71篇 |
2000年 | 63篇 |
1999年 | 74篇 |
1998年 | 73篇 |
1997年 | 73篇 |
1996年 | 59篇 |
1995年 | 53篇 |
1994年 | 58篇 |
1993年 | 54篇 |
1992年 | 59篇 |
1991年 | 70篇 |
1990年 | 50篇 |
1989年 | 48篇 |
1988年 | 49篇 |
1987年 | 53篇 |
1986年 | 54篇 |
1985年 | 43篇 |
1984年 | 53篇 |
1983年 | 45篇 |
1982年 | 24篇 |
1981年 | 39篇 |
1980年 | 22篇 |
1979年 | 24篇 |
1978年 | 21篇 |
1977年 | 14篇 |
1975年 | 13篇 |
1974年 | 16篇 |
1973年 | 13篇 |
排序方式: 共有4751条查询结果,搜索用时 129 毫秒
961.
Tateki Morikawa M.D. Noboru Terauchi M.D. Hideo Shigematsu M.D. Masayasu Tsuji M.D. Mitsuhiro Fukai M.D. Kazuichi Yagi M.D. Masakazu Seino M.D. 《Psychiatry and clinical neurosciences》1986,40(3):301-306
Abstract: Out of the 314 children with partial epilepsies below the age of 15 who had been followed for more than 5 years, 122 children with functional partial epilepsies (FPE) were the subjects of this study. The specific modality of interictal EEG findings reminiscent of that of the Rolandic spikes (Dalla Bernardina, 1982, 1984) was compared between functional and organic partial epilepsies.
The results were: 1) One hundred and twenty-two patients were found to have FPE out of a total of 314 patients (39%). 2) Fifty-five patients were diagnosed as typical benign epilepsy of children with centra-temporal EEG foci (BECCT) of the 122 functional cases (45%). The remaining 67 patients who defied the diagnostic criteria of BECCT were; 9 cases with frontal EEG focus (7%), 11 cases with central and/or mid-temporal EEG foci (9%), 10 cases with occipital EEG focus (8%) and 14 cases with multiple foci (11%). 3) Unfavorable seizure control was observed in cases with frontal foci (44%) and with multiple EEG foci (64%) compared with those whose EEG focus was located in the centro-midtemporal area, (including BECCT; 98%) and in the occipital region (80%). 4) It was noteworthy that the recurrent interictal spikes similar to those of the Rolandic spikes (Dalla Bernardina) were found in more than 50% of the patients not only with functional but with organic partial epilepsies. Our results, at least at the present time, appear to indicate that the recurrent spikes never did signify the benignancy of the seizure prognosis. The importance of differential diagnosis of BECCT from FPE was specifically stressed. 相似文献
The results were: 1) One hundred and twenty-two patients were found to have FPE out of a total of 314 patients (39%). 2) Fifty-five patients were diagnosed as typical benign epilepsy of children with centra-temporal EEG foci (BECCT) of the 122 functional cases (45%). The remaining 67 patients who defied the diagnostic criteria of BECCT were; 9 cases with frontal EEG focus (7%), 11 cases with central and/or mid-temporal EEG foci (9%), 10 cases with occipital EEG focus (8%) and 14 cases with multiple foci (11%). 3) Unfavorable seizure control was observed in cases with frontal foci (44%) and with multiple EEG foci (64%) compared with those whose EEG focus was located in the centro-midtemporal area, (including BECCT; 98%) and in the occipital region (80%). 4) It was noteworthy that the recurrent interictal spikes similar to those of the Rolandic spikes (Dalla Bernardina) were found in more than 50% of the patients not only with functional but with organic partial epilepsies. Our results, at least at the present time, appear to indicate that the recurrent spikes never did signify the benignancy of the seizure prognosis. The importance of differential diagnosis of BECCT from FPE was specifically stressed. 相似文献
962.
Toshihide Shike Tomohito Gohda Mitsuo Tanimoto Michimasa Kobayashi Yuichiro Makita Kazuhiko Funabiki Satoshi Horikoshi Sachiko Hirose Toshikazu Shirai Yasuhiko Tomino 《Nephrology, dialysis, transplantation》2005,20(5):879-885
BACKGROUND: The KK/Ta mouse strain serves as a suitable polygenic model for human type 2 diabetes. We previously reported a genome-wide linkage analysis of KK/Ta alleles contributing to type 2 diabetes and related phenotypes such as fasting hyperglycaemia, glucose intolerance, hyperinsulinaemia, obesity and dyslipidaemia. METHODS: Since KK/Ta mice spontaneously develop renal lesions closely resembling those in human diabetic nephropathy, we investigated the susceptibility loci using the KK/Ta x (BALB/c x KK/Ta) F1 backcross progeny in the present study. RESULTS: A genome-wide analysis of susceptibility loci for albuminuria with microsatellite-based chromosomal maps showed a contributing KK/Ta locus, provisionally designated UA-1, with a significant linkage with the interval on chromosome 2 at 83.0 cM close to the microsatellite marker D2Mit311 with a maximum LOD of 3.5 (chi(2) = 13.2, P = 0.0003). UA-1 was different from the susceptibility loci contributing to type 2 diabetes, which we earlier identified. The mode of inheritance differed from that of hypertension. The progeny homozygous for UA-1 showed significantly higher urinary albumin levels. CONCLUSIONS: Although there were no significant correlations between urinary albumin levels and other diabetic phenotypes, the group of progeny homozygous for both UA-1 and alleles for fasting hyperglycaemia showed the highest urinary albumin levels. Thus, UA-1 appears to increase the risk of diabetic nephropathy, particularly in individuals susceptible to fasting hyperglycaemia, in a gene dosage-dependent manner. There are potentially important candidate genes that may be relevant to diabetic nephropathy. 相似文献
963.
Shigeru Fujimoto MD Ram Dhoj Shrestha Junji Kasanuki Masashi Kokubun Noboru Ichiki Akira Miyazaki Masayasu Ohta Katsuji Okui 《Surgery today》1987,17(4):307-311
We report herein the clinical events seen in two longterm survivors of gastric cancer with unresectable synchronous hepatic
metastases. Partial gastrectomy was performed against the primary lesion and continuous intra-arterial infusion of anti-tumor
drugs, followed by prolonged systemic antitumor drug treatment, were prescribed. A 43-year-old man with moderately-differentiated
tubular adenocarcinoma had an uneventful course during his first 21 postoperative months. However, multiple liver metastases
became manifest at 24 months and enlargement of the intrahepatic foci led to death 27 months after gastrectomy. A 51-year-old
woman with moderagely-differentiated tubular adenocarcinoma had an uneventful postoperative course and is now well with no
signs of recurrence 6 years and 6 months after gastrectomy. 相似文献
964.
Prediction of the Distribution Volumes of Cefazolin and Tobramycin in Obese Children Based on Physiological Pharmacokinetic Concepts 总被引:1,自引:0,他引:1
Koshida Rie Nakashima Emi Taniguchi Noboru Tsuji Akira Benet Leslie Z. Ichimura Fujio 《Pharmaceutical research》1989,6(6):486-491
So as to estimate the appropriate dose of antibacterial drugs in obese children, prediction of the volume of distribution in these children was attempted based on physiological pharmacokinetic concepts which had been constructed from results in normal-weight children. Serum concentration–time data after intravenous drip infusions of tobramycin and cefazolin were analyzed using noncompartmental analysis of obese children in whom the degree of obesity ranged from 30 to 80%. Volume of distribution at steady state (V
ss) per total body weight of tobramycin was significantly less than that for normal-weight children (P < 0.05), whereas the value of cefazolin was almost equal to that for normal-weight children. The equation to express the difference of Vss between cefazolin and tobramycin obtained in normal-weight children failed in obese children, suggesting that there is a large decrease in the extracellular space in obese children exceeding the interindividual variations in normal-weight children. The V
ss value (liter) for tobramycin was predicted by using the equation 0.261 · {ideal body weight (kg) + 0.4 · [total body weight (kg) – ideal body weight (kg)]}. The V
ss value of cefazolin was predicted to be 0.3 · (predicted V
ss of tobramycin) + 0.052 · total body weight (kg). A good correlation between the predicted and the observed V
ss values was obtained. 相似文献
965.
M. Tamura H. Kohga N. Ono A. Zama T. Shibasaki S. Horikoshi H. Kurihara C. Ohye 《Child's nervous system》1995,11(3):141-144
Three pediatric cases of temporal lobe seizure due to calcified glioma of amygdalo-hippocampal region are described. Computed tomography and magnetic resonance imaging showed dense calcification with no postcontrast enhancement in the amygdalo-hippocampal region. Positron emission tomography showed low oxygen metabolism, low glucose metabolism, hypermetabolism of amino acids, and low regional cerebral blood flow in the tumors. Single photon emission computed tomography showed a high accumulation of201Tl chloride and123I-isopropyl iodoamphetamine in one tumor, but otherwise low radioisotope uptake. These studies indicated lowgrade malignancies. The patients were treated by partial tumor removal and radiotherapy. Histological examination of the tumor specimens showed astrocytoma with interstitial calcification. One patient died due to tumor recurrence, while the others are doing well with minimal seizure. We recommended temporal lobectomy in similar cases to achieve complete remission. 相似文献
966.
967.
968.
Taku Suzuki Takuji Iwamoto Noboru Matsumura Hiroo Kimura Masaya Nakamura Morio Matsumoto Kazuki Sato 《Journal of hand and microsurgery》2021,13(2):69
This retrospective study evaluated procedural failures of closed reductions using an extension-block Kirschner wire (K-wire) for bony mallet finger. A total of 132 patients who underwent a closed reduction for bony mallet finger in a procedure using an extension-block K-wire were radiographically assessed. Radiographs were used to evaluate (1) postoperative displacement of the reduction before or after K-wire removal and (2) inaccurate reduction of the fragment immediately after surgery. The causes of procedural failure and bone union were evaluated using radiographs and medical records of the intraoperative findings. Out of 132 patients, 17 with procedural failure were enrolled. Displacement of the reduction before and after K-wire removal occurred in seven and six cases, respectively. Inaccurate reduction immediately after surgery occurred in four cases. The most common cause of procedural failure was inaccurate insertion of the K-wire to fix the distal interphalangeal joint (eight cases) followed by inaccurate insertion of the extension-block pin (five cases). All patients had bone union regardless of the displacement of the reduction or inaccurate reduction of the fragment. Caution should be exercised during the reduction and fixation when an extension-block K-wire is used in a closed reduction procedure. 相似文献
969.
Nobuyoshi Takeuchi Shinichi Sakamoto Akira Nishiyama Takuro Horikoshi Yasutaka Yamada Junpei Iizuka Maihulan Maimaiti Yusuke Imamura Koji Kawamura Takashi Imamoto Akira Komiya Yuzuru Ikehara Koichiro Akakura Tomohiko Ichikawa 《Clinical genitourinary cancer》2018,16(4):e817-e829
Background
We retrospectively assessed the clinical significance of the Prostate Imaging Reporting and Data System (PI-RADS), version 2, criteria based on biparametric magnetic resonance imaging (bp-MRI), together with the International Society of Urological Pathology (ISUP) grade, for predicting biochemical recurrence (BCR) after radical prostatectomy.Materials and Methods
The data from 126 patients who had undergone radical prostatectomy were retrospectively analyzed. The prognostic significance of the PI-RADS v2 score based on bp-MRI was assessed with other clinical factors, including the ISUP grade. We defined a positive PI-RADS and ISUP score as ≥ 4 and ≥ 3, respectively. Statistical analysis was performed using Cox proportional hazard models, logistic regression analysis, and the Kaplan-Meier method.Results
The median age and median prostate-specific antigen level were 66 years and 7.96 ng/mL, respectively. The number of positive PI-RADS scores was 106 (84.1%) and the number of positive ISUP grade scores was 71 (56.3%). PI-RADS ≥ 4 (P = .0031) and ISUP ≥ 3 (P = .070) were the 2 independent prognostic factors predictive of BCR. A positive PI-RADS score was related to tumor volume (P = .014), and a positive ISUP score was related to prostate-specific antigen level (P = .043), extraprostatic extension (P = .029), and Gleason upgrading (P < .0001). After stratifying patients into risk groups according to PI-RADS and ISUP positivity, the poor-risk group (PI-RADS and ISUP grade positive) showed significantly worse BCR-free survival compared with that of the favorable- and intermediate-risk groups (P < .0001), with a median survival difference of 21 months.Conclusion
Biparametric PI-RADS v2 and ISUP grade criteria predicted for BCR after radical prostatectomy. PI-RADS v2 combined with the ISUP grade might be helpful in choosing the treatment modality of patients with localized prostate cancer. 相似文献970.
Hirohisa Kato M.D. Osamu Inoue M.D. Eisei Ichinose M.D. Teiji Akagi M.D. Noboru Sato M.D. 《Pediatrics international》1991,33(1):27-35
The main cause of death in Kawasaki disease is myocardial infarction due to thrombotic occlusion of a coronary aneurysm. Intracoronary thrombolytic treatment was performed in 15 patients with Kawasaki disease with giant coronary aneurysms. Three patients had acute myocardial infarction, four demonstrated silent myocardial infarction, three suffered chest pain and five did not show ischemia features but had massive thrombus in the coronary aneurysms. Urokinase was infused into the coronary aneurysms as a bolus of 8,000 to 10,000 units/kg via a catheter over 10 minutes. Partial but significant coronary recanalization was achieved after injection of urokinase in a patient with acute myocardial infarction. Complete resolution of massive intracoronary thrombi was observed in 3 of 15 patients, and partial resolution was recognized in 4 cases. In 7 patients, the size of thrombus did not change. Recurrence of the thrombus was observed in 4 patients by serial two-dimensional echocardiography. Urokinase was readmmistered and two showed significant reduction in the thrombus. All patients have been followed for more than 2 years with longest 8 years (mean: 3.3 yrs), and none have had a recurrence of myocardial infarction or died. These findings suggest that intracoronary urokinase is useful for the treatment and prevention of myocardial infarction in Kawasaki disease. 相似文献