钛网结合钛钢板在多节段颈椎前柱结构重建中的作用

目的:探讨钛网钛钢板内固定在多节段颈椎间盘突出症中的应用价值.方法:采用钛网钛板内固定的方法治疗颈椎间盘突出18例,平均随访时间为18个月,观察病人的植骨融合率、椎间高度、颈椎生理曲度、内植物的并发症及进行功能评定.结果:18例均获得骨性愈合,术后椎间高度和生理曲度维持满意,未发生内植物并发症.功能评定优14例,良3例,可1例.优良率为94%.结论:采用钛板钛网内固定可使脊柱立即获得稳定,植骨愈合率高,有效地维持椎间高度和生理曲度,早期下床活动.     

Improvement on conventional constant current DC iontophoresis: a study using constant conductance AC iontophoresis.

The purpose of the present study was to compare conventional constant direct current (DC) transdermal iontophoresis with a new constant conductance alternating current (AC) iontophoresis method. The new method was developed with the intent of reducing flux drift during iontophoresis and minimizing skin-to-skin variability. The constant conductance AC iontophoresis studies involved three electrical components: (1) an initial applied potential used to decrease the human epidermal membrane (HEM) electrical resistance to a target level of either 1.5 or 3.0 k Omega cm(2), (2) an applied 50 Hz square-wave AC with a variable potential adjusted to maintain the HEM conductance at the target level during the transport study, and (3) a low voltage DC offset of 0 (passive), 0.25, or 0.40 V applied simultaneously with the AC to assist permeant transport. Current densities of 0.13 and 0.26 mA/cm(2) were chosen for the conventional constant current DC iontophoresis studies. Mannitol was used as the probe permeant for all studies. The constant current DC studies showed significant increases in mannitol flux with time during a given experiment and large skin-to-skin variability. Compared to the constant current DC experiments, the mannitol flux remained more constant during the constant conductance AC iontophoresis and skin-to-skin variability was significantly reduced. On a mechanistic level, changes in the transport properties during constant current DC iontophoresis indicate changes in the membrane parameters such as porosity, effective pore size, and/or pore surface charge density during the conventional method of iontophoresis. The results from the constant conductance AC iontophoresis transport studies imply that this method effectively maintains the membrane parameters that affect transport at a constant state this providing for a relatively constant permanent flux.     

胃TFE3阳性富含色素的血管周上皮样细胞肿瘤1例

胃血管周上皮样细胞肿瘤(PEComa)是一种罕见发生于胃的具有血管周上皮样细胞特征的间叶性肿瘤。本文报道1例发生于胃体上部前壁黏膜下PEComa。内镜下行黏膜下肿物挖除术, 术后病理组织形态表现为富含色素的上皮样肿瘤细胞被含小血管网的间质分隔成巢状。免疫组织化学HMB45、结蛋白、TFE3阳性。最终诊断:胃TFE3阳性富含色素的PEComa。通过分析本例肿瘤临床病理特征, 对胃肠道PEComa临床病理特征、免疫组织化学及分子检测进行回顾性分析, 以提高病理医师对胃肠道PEComa的认识。     

Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene

Over the last decade our insight into the causes of neonatal diabetes has greatly expanded. Neonatal diabetes was once considered a variant of type 1 diabetes that presented early in life. Recent advances in our understanding of this disorder have established that neonatal diabetes is not an autoimmune disease, but rather is a monogenic form of diabetes resulting from mutations in a number of different genes encoding proteins that play a key role in the normal function of the pancreatic beta-cell. Moreover, a correct genetic diagnosis can affect treatment and clinical outcome. This is especially true for patients with mutations in the genes KCNJ11 or ABCC8 that encode the two protein subunits (Kir6.2 and SUR1, respectively) of the ATP-sensitive potassium channel. These patients can be treated with oral sulfonylurea drugs with better glycemic control and quality of life. Recently, mutations in the insulin gene (INS) itself have been identified as another cause of neonatal diabetes. In this article, we review the role of INS mutations in the pathophysiology of neonatal diabetes.     

浙江省高中学生精神活性物质使用情况调查

目的:了解浙江省高中生精神活性物质使用情况,为预防控制精神活性物质滥用行为提供依据。方法:采用随机整体抽样法对浙江省3472名高中生进行调查。结果:共回收有效问卷3215份,24.0%的调查对象尝试过吸烟,68.9%尝试过饮酒,1.4%使用过镇静催眠药(46人),0.9%使用过苯丙胺类中枢兴奋剂或挥发性溶剂或毒品(29人)。家庭因素、教育方式、学生成绩、睡眠情况以及上网时间等均对学生吸烟饮酒的比例有很大影响。结论:高中学生中普遍存在精神活性物质滥用行为,应引起家庭、学校和社会的高度重视,采取有针对性的干预措施,以控制该类行为的蔓延。     

Weighted Markov chains for forecasting and analysis in Incidence of infectious diseases in jiangsu Province, China

This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence course. Then the paper presents a weighted Markov chain, a method which is used to predict the future incidence state. This method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic variable. It also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision optimal. Our method is successfully validated using existing incidents data of infectious diseases in Jiangsu Province. In summation, this paper proposes ways to improve the accuracy of the weighted Markov chain, specifically in the field of infection epidemiology.     

血糖和糖化血清蛋白在急性颅脑损伤患者的检测价值

目的：通过检测急性颅脑损伤后血糖（Glu）和糖化血清蛋白（GSP）水平变化,探讨其检测价值。方法：检测了31例糖尿病颅脑损伤患者和47例无糖尿病颅脑损伤患者Glu、GSP水平变化,并与30例健康对照组做了比较。结果：糖尿病组和无糖尿病组颅脑损伤患者血糖水平均显著高于对照组（P〈0.01）;糖尿病组患者GSP水平显著高于无糖尿病颅脑损伤组和对照组,无糖尿病颅脑损伤组的GSP水平与对照组相比差异无显著性（P〉0.05）。无糖尿病急性颅脑损伤患者入院时和痊愈出院时比较血糖水平差异有显著性（P〈0.01）;GSP水平差异无显著性（P〉0.05）。结论：Glu检测可以作为急性颅脑损伤患者监测病情,评估预后具有重要临床使用价值。GSP检测可以作为鉴别急性颅脑损伤患者血糖增高是应激性还是糖尿病性重要依据,也可作为检测急性颅脑损伤患者是否有糖尿病的一种方法。     

舒利迭治疗慢性阻塞性肺病的临床分析

[目的]观察舒利迭治疗慢性阻塞性肺病（COPD）的疗效。[方法]选择COPD患者60例,随机分为治疗组30例和对照组30例,在常规治疗基础上对照组吸入普米克都保,治疗组吸入舒利迭。根据圣.乔治（St.George）呼吸疾病问卷（SGRQ）的方法,进行临床症状及体症检查评分,测定肺功能指标FEV1,FEV1/FVC及FEV1占预计值（%）来评价治疗前后肺功能的变化。[结果]舒利迭组治疗后临床症状及肺功能指标明显优于对照组（P〈0.05）。[结论]舒利迭是治疗COPD的有效药物,使用安全。     

我院173份中成药说明书的分析

目的 了解中成药说明书内容的完整性,给医师和患者安全使用中成药提供重要的信息.方法 收集我院正在使用的中成药说明书173份,对其23项内容的完整性进行调查统计.结果 173份中成药说明书中处方药115种,占66.5％;非处方药58种,占33.5％.其中药品名称、性状、功能与主治、用法用量、不良反应、禁忌、注意事项、贮藏、包装、有效期、执行标准、批准文号、说明书修订日期和生产企业等14项标识率虽为100％,但是在不良反应、禁忌、注意事项等方面还存在一些问题.结论 应进一步加强中成药说明书的管理,为人们正确、合理用药提供法定依据.     

高效液相色潽法检测复方二氧丙嗪茶碱片中茶碱含量

目的:建立高效液相色谱法检测复方二氧丙嗪茶碱片中茶碱含量.方法:色谱柱为Kromasil-C18(250 mm×4.6 mm,5 μm);流动相为水-甲醇(65:35);流速为1.0 ml·min-1;检测波长:275 nm.结果:茶碱在0.107～5.335 μg·ml-1范围内,与峰面积值呈良好的线性关系,r=0.999 7;平均加样回收率为100.1%,RSD=0.36%(n=9).结论:方法简便、准确、重复性好,可用于该制剂的含量测定.