全文获取类型
收费全文 | 5731篇 |
免费 | 307篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 82篇 |
妇产科学 | 82篇 |
基础医学 | 665篇 |
口腔科学 | 116篇 |
临床医学 | 333篇 |
内科学 | 1714篇 |
皮肤病学 | 158篇 |
神经病学 | 441篇 |
特种医学 | 241篇 |
外科学 | 908篇 |
综合类 | 25篇 |
预防医学 | 158篇 |
眼科学 | 68篇 |
药学 | 398篇 |
中国医学 | 28篇 |
肿瘤学 | 603篇 |
出版年
2023年 | 28篇 |
2022年 | 52篇 |
2021年 | 122篇 |
2020年 | 84篇 |
2019年 | 83篇 |
2018年 | 121篇 |
2017年 | 111篇 |
2016年 | 133篇 |
2015年 | 155篇 |
2014年 | 169篇 |
2013年 | 194篇 |
2012年 | 353篇 |
2011年 | 410篇 |
2010年 | 211篇 |
2009年 | 199篇 |
2008年 | 332篇 |
2007年 | 373篇 |
2006年 | 336篇 |
2005年 | 339篇 |
2004年 | 343篇 |
2003年 | 397篇 |
2002年 | 361篇 |
2001年 | 98篇 |
2000年 | 66篇 |
1999年 | 102篇 |
1998年 | 74篇 |
1997年 | 48篇 |
1996年 | 64篇 |
1995年 | 44篇 |
1994年 | 73篇 |
1993年 | 43篇 |
1992年 | 70篇 |
1991年 | 60篇 |
1990年 | 47篇 |
1989年 | 40篇 |
1988年 | 37篇 |
1987年 | 52篇 |
1986年 | 27篇 |
1985年 | 28篇 |
1984年 | 21篇 |
1983年 | 11篇 |
1982年 | 21篇 |
1981年 | 17篇 |
1980年 | 17篇 |
1979年 | 16篇 |
1978年 | 7篇 |
1977年 | 13篇 |
1975年 | 7篇 |
1971年 | 9篇 |
1969年 | 9篇 |
排序方式: 共有6073条查询结果,搜索用时 93 毫秒
81.
82.
Analysis of possible structures of inducible skin‐associated lymphoid tissue in lupus erythematosus profundus 下载免费PDF全文
Toshiaki Kogame Ryosuke Yamashita Masahiro Hirata Tatsuki R. Kataoka Hisashi Kamido Chiyuki Ueshima Miho Matsui Takashi Nomura Kenji Kabashima 《The Journal of dermatology》2018,45(9):1117-1121
Lupus erythematosus profundus (LEP) is a variant of lupus erythematosus, involving the deep dermis and subcutaneous fat. LEP is characterized by the presence of lymphoid follicles (LF) and germinal centers (GC). However, it remains unknown whether these lymphoid structures correspond to the lymphoid tissues such as cutaneous tertiary lymphoid organs (TLO). Previously, we identified dynamically orchestrated cellular elements in murine contact dermatitis that resembled lymphoid structures, which we termed inducible skin‐associated lymphoid tissues (iSALT). We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans. Here, we studied ectopic lymphoid tissues in the lesions of LEP by immunohistochemistry and compared their characteristics with those of TLO. We demonstrated that LF of LEP were composed of B‐cell follicles intermingled with CXCL13‐expressing cells, distinct aggregations of T cells, and some blood vessels expressing peripheral node addressin. These findings indicate that LF of LEP can be considered as a type of iSALT. 相似文献
83.
84.
Kohei Horimoto Junji Kato Yasuyuki Sumikawa Tokimasa Hida Takafumi Kamiya Sayuri Sato Hitomi Takahashi Masahide Sawada Toshiharu Yamashita Hisashi Uhara 《The Journal of dermatology》2018,45(4):487-490
We examined dermoscopic features of three cases of extraocular sebaceous carcinoma and reviewed the literatures. The yellowish structures, polymorphous vessels and ulceration were common findings in our cases and all cases of the previous reports. The appearance of whitish‐pink areas has not been described previously. Our results suggested that the combination of four dermoscopic features, whitish‐pink areas, yellowish structures, polymorphous vessels and ulceration might be distinctive in extraocular sebaceous carcinoma. 相似文献
85.
Ryota Sakurai Hisashi Kawai Hiroyuki Suzuki Hunkyung Kim Yutaka Watanabe Hirohiko Hirano Kazushige Ihara Shuichi Obuchi Yoshinori Fujiwara 《Journal of epidemiology / Japan Epidemiological Association》2021,31(4):297
ObjectivesEating alone is associated with an increased risk of depression symptoms. This association may be confounded by poor social networks. The present study aimed to determine the role of poor social networks in the association of eating alone with depression symptoms, focusing on cohabitation status.MethodsSeven hundred and ten community-dwelling older adults were categorized according to their eating style and social network size, evaluated using an abbreviated version of the Lubben Social Network Scale, with poor social network size (defined as the lowest quartile). Living arrangements and depression symptoms, detected using the Zung Self-Rating Depression Scale, were also assessed.ResultsA mixed-design two-way analysis of covariance (eating style and social network size factors) for the depression scale score, adjusted by covariates, yielded significant effects of social network size and eating style without interaction. Greater depression scores were observed in eating alone and poor social network size. Analysis of participants living with others showed the same results. However, among older adults living alone, only a significant main effect of social network size was observed; poor social network size resulted in greater depression scores irrespective of eating style.ConclusionsPoor social network size, and not eating alone, was associated with greater depression symptoms among older adults living alone, whereas both factors may increase depression symptoms among older adults living with others. Poor social network size may show a stronger influence on depression than eating alone in older adults living alone; thus, social network size is an important health indicator.Key words: eating alone, social network, living alone, depression, older adults 相似文献
86.
87.
Kosuke Nomura Toshiro Iizuka Daisuke Kaji Hisashi Yamamoto Yasutaka Kuribayashi Ryusuke Kimura Akihiro Yamada Tsukasa Furuhata Satoshi Yamashita Daisuke Kikuchi Akira Matsui Toshifumi Mitani Osamu Ogawa Shu Hoteya Yasunori Ota Shuichi Taniguchi Mitsuru Kaise 《Journal of gastroenterology and hepatology》2014,29(11):1867-1872
88.
89.
Safety and efficacy of nivolumab in Japanese patients with malignant melanoma: An interim analysis of a postmarketing surveillance 下载免费PDF全文
Yoshio Kiyohara Hisashi Uhara Yoshihiko Ito Noritake Matsumoto Tetsuya Tsuchida Naoya Yamazaki 《The Journal of dermatology》2018,45(4):408-415
A postmarketing surveillance study is ongoing to evaluate nivolumab treatment for Japanese patients with malignant melanoma and accumulate data on all adverse events (AE) and efficacy. In this interim analysis, we evaluated data from approximately 100 Japanese medical institutions obtained from the nivolumab approval date in Japan (4 July 2014) through 3 July 2016. Patients were monitored during the first 12 months of treatment. Nivolumab was administrated by i.v. infusion (2 mg/kg every 3 weeks). A total of 680 and 610 patients were evaluated for safety and efficacy, respectively. The incidences of adverse drug reactions (ADR) and grade 3 or higher ADR were 53.53% and 12.35%, respectively. Predominant ADR included hypothyroidism (11.32%) and abnormal enzyme activity, such as increase of aspartate aminotransferase (7.79%), alanine aminotransferase (6.76%), alkaline phosphatase (6.18%) and γ‐glutamyltransferase (5.44%). Grade 3 or higher ADR of special interest with an incidence of 1% or higher were hepatic function disorder (2.50%), colitis/diarrhea (2.06%) and infusion reaction (1.32%). No cases of encephalitis or venous thromboembolism, other AE of special interest, were observed. The estimated median overall survival was 379 days (95% confidence interval [CI], 290–not reached [NR]) in the overall population, NR (95% CI, 305–NR) for cutaneous melanoma and 340 days (95% CI, 275–NR) for mucosal melanoma. The improvement rate based on the antitumor response at the last evaluation was 22.2% (131/590 patients). No new safety concerns were raised, and serious ADR of special interest were infrequent. Nivolumab showed equivalent efficacy in patients with mucosal melanoma and those with cutaneous melanoma. 相似文献
90.