全文获取类型
收费全文 | 4812篇 |
免费 | 228篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 72篇 |
儿科学 | 99篇 |
妇产科学 | 29篇 |
基础医学 | 543篇 |
口腔科学 | 62篇 |
临床医学 | 388篇 |
内科学 | 1748篇 |
皮肤病学 | 180篇 |
神经病学 | 268篇 |
特种医学 | 161篇 |
外科学 | 601篇 |
综合类 | 12篇 |
预防医学 | 168篇 |
眼科学 | 34篇 |
药学 | 183篇 |
中国医学 | 1篇 |
肿瘤学 | 526篇 |
出版年
2023年 | 26篇 |
2022年 | 75篇 |
2021年 | 115篇 |
2020年 | 67篇 |
2019年 | 86篇 |
2018年 | 97篇 |
2017年 | 75篇 |
2016年 | 82篇 |
2015年 | 104篇 |
2014年 | 122篇 |
2013年 | 156篇 |
2012年 | 269篇 |
2011年 | 242篇 |
2010年 | 119篇 |
2009年 | 98篇 |
2008年 | 158篇 |
2007年 | 175篇 |
2006年 | 185篇 |
2005年 | 196篇 |
2004年 | 179篇 |
2003年 | 201篇 |
2002年 | 194篇 |
2001年 | 165篇 |
2000年 | 153篇 |
1999年 | 151篇 |
1998年 | 60篇 |
1997年 | 46篇 |
1996年 | 37篇 |
1995年 | 24篇 |
1994年 | 38篇 |
1993年 | 35篇 |
1992年 | 114篇 |
1991年 | 109篇 |
1990年 | 109篇 |
1989年 | 115篇 |
1988年 | 83篇 |
1987年 | 89篇 |
1986年 | 97篇 |
1985年 | 96篇 |
1984年 | 75篇 |
1983年 | 76篇 |
1982年 | 29篇 |
1980年 | 24篇 |
1979年 | 45篇 |
1978年 | 31篇 |
1977年 | 22篇 |
1976年 | 21篇 |
1974年 | 36篇 |
1973年 | 21篇 |
1972年 | 27篇 |
排序方式: 共有5075条查询结果,搜索用时 15 毫秒
991.
992.
Kanako Hagio Junko Kikuchi Kohichi Takada Hiroki Tanabe Minako Sugiyama Yoshihito Ohhara Toraji Amano Satoshi Yuki Yoshito Komatsu Takahiro Osawa Kanako C. Hatanaka Yutaka Hatanaka Takashi Mitamura Ichiro Yabe Yoshihiro Matsuno Atsushi Manabe Akihiro Sakurai Atsushi Ishiguro Masato Takahashi Hiroshi Yokouchi Hirohito Naruse Yusuke Mizukami Hirotoshi Dosaka-Akita Ichiro Kinoshita 《Cancer science》2023,114(8):3385-3395
Comprehensive genomic profiling (CGP) tests have been covered by public insurance in Japan for patients with advanced solid tumors who have completed or are completing standard treatments or do not have them. Therefore, genotype-matched drug candidates are often unapproved or off-label, and improving clinical trial access is critical, involving the appropriate timing of CGP tests. To address this issue, we analyzed the previous treatment data for 441 patients from an observational study on CGP tests discussed by the expert panel at Hokkaido University Hospital between August 2019 and May 2021. The median number of previous treatment lines was two; three or more lines accounted for 49%. Information on genotype-matched therapies was provided to 277 (63%). Genotype-matched clinical trials were ineligible because of an excess number of previous treatment lines or use of specific agents were found in 66 (15%) patients, with the highest proportion in breast and prostate cancers. Many patients met the exclusion criteria of one to two or more treatment lines across cancer types. In addition, previous use of specific agents was a frequent exclusion criterion for breast, prostate, colorectal, and ovarian cancers. The patients with tumor types with a low median number (two or fewer) of previous treatment lines, including most rare cancers, primary unknown cancers, and pancreatic cancers, had significantly fewer ineligible clinical trials. The earlier timing of CGP tests may improve access to genotype-matched clinical trials, with their proportion varying by cancer type. Each relevant society needs to advocate the desirable timing of CGP testing nationwide. 相似文献
993.
Stones in the common bile duct (CBD) are reported worldwide, and this condition is majorly managed through endoscopic retrograde cholangiopancreatography (ERCP). CBD stone recurrence is an important issue after endoscopic stone removal. Therefore, it is essential to identify its risk factors to determine the necessity of regular follow-up in patients who underwent endoscopic removal of CBD stones. The authors identified that the S and polyline morphological subtypes of CBD were associated with increased stone recurrence. New morphological subtypes of CBD presented by the authors can be important risk predictors of recurrence after endoscopic stone removal. Furthermore, the new morphological subtypes of CBD may predict the risk of residual CBD stones or technical difficulty in CBD stone removal. Further studies with a large sample size and longer follow-up durations are warranted to examine the usefulness of the newly identified morphological subtypes of CBD in predicting the outcomes of ERCP for CBD stone removal. 相似文献
994.
995.
996.
997.
998.
Rina Nanba Satoshi Kuroda Mitsuhiro Tada Tatsuya Ishikawa Kiyohiro Houkin Yoshinobu Iwasaki 《Child's nervous system》2006,22(3):258-262
Objects This study aims to clarify the genetic background of moyamoya disease by comparing clinical features between familial and sporadic cases to reveal the responsible genes for familial moyamoya disease.Methods This study included 155 Japanese patients with moyamoya disease, which included 24 familial cases (10 family pedigrees) and 131 sporadic cases. Clinical features were compared between the familial and sporadic cases.Results and conclusion A female preponderance was significantly more prominent in the familial than in the sporadic group (P=0.0421). Mean age at onset was significantly lower in familial than in sporadic cases (P=0.004). In eight parent–offspring pairs, mean age at onset was significantly lower in the second than in the first generation (P<0.0001). These results suggest that familial moyamoya disease is associated with genetic anticipation and female predominance and that a genetic analysis study focused on expanded triplet repeats may clarify the pathogenesis of the disease. 相似文献
999.
Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor 总被引:31,自引:12,他引:19
下载免费PDF全文
![点击此处可从《The Journal of experimental medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
T Takeshita Y Goto K Tada K Nagata H Asao K Sugamura 《The Journal of experimental medicine》1989,169(4):1323-1332
A mouse hybridoma cell line, TU27, producing an mAb was established. TU27 mAb reacted with various human and Gibbon ape T cell lines bearing the IL-2R p75 (IL-2Rp75), but not with cell lines expressing only Tac antigen, IL-2Rp55, and numbers of its binding sites on cell surfaces were similar to those of high-affinity IL-2R. Radioimmunoprecipitation with TU27 mAb defined a molecule with a molecular mass of 75 kD on the surface of IL-2Rp75 bearing cells. TU27 mAb completely blocked IL-2 binding to IL-2Rp75 and to the high-affinity IL-2R but not to IL-2Rp55 composing the low-affinity IL-2R. The IL-2-dependent growth of a human T cell line, ILT-Mat, was significantly inhibited by TU27 mAb only at low concentrations of IL-2, and combination of TU27 mAb and H-31 mAb specific for IL-2Rp55 completely inhibited the cell growth even at high concentrations of IL-2. These data strongly suggest that TU27 mAb is specific for the human IL-2Rp75. 相似文献
1000.