全文获取类型
收费全文 | 4444篇 |
免费 | 243篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 88篇 |
儿科学 | 54篇 |
妇产科学 | 51篇 |
基础医学 | 533篇 |
口腔科学 | 80篇 |
临床医学 | 191篇 |
内科学 | 1316篇 |
皮肤病学 | 50篇 |
神经病学 | 362篇 |
特种医学 | 89篇 |
外科学 | 1001篇 |
综合类 | 12篇 |
预防医学 | 90篇 |
眼科学 | 86篇 |
药学 | 193篇 |
中国医学 | 6篇 |
肿瘤学 | 525篇 |
出版年
2023年 | 49篇 |
2022年 | 80篇 |
2021年 | 116篇 |
2020年 | 74篇 |
2019年 | 114篇 |
2018年 | 137篇 |
2017年 | 112篇 |
2016年 | 126篇 |
2015年 | 116篇 |
2014年 | 180篇 |
2013年 | 185篇 |
2012年 | 341篇 |
2011年 | 301篇 |
2010年 | 159篇 |
2009年 | 138篇 |
2008年 | 247篇 |
2007年 | 256篇 |
2006年 | 260篇 |
2005年 | 257篇 |
2004年 | 248篇 |
2003年 | 222篇 |
2002年 | 194篇 |
2001年 | 71篇 |
2000年 | 71篇 |
1999年 | 86篇 |
1998年 | 56篇 |
1997年 | 44篇 |
1996年 | 28篇 |
1995年 | 22篇 |
1994年 | 32篇 |
1993年 | 21篇 |
1992年 | 48篇 |
1991年 | 53篇 |
1990年 | 34篇 |
1989年 | 34篇 |
1988年 | 29篇 |
1987年 | 19篇 |
1986年 | 18篇 |
1985年 | 22篇 |
1984年 | 15篇 |
1983年 | 11篇 |
1982年 | 7篇 |
1981年 | 10篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1975年 | 8篇 |
1974年 | 9篇 |
1972年 | 5篇 |
排序方式: 共有4727条查询结果,搜索用时 15 毫秒
101.
Hiroaki Shikano Hidenori Ohnishi Hisashi Fukutomi Kimiko Ito Masahiro Morimoto Takahide Teramoto Mitsuhiro Aoki Takezumi Nishihori Yukihiro Akeda Kazunori Oishi Toshiyuki Fukao 《Pediatrics international》2015,57(6):1192-1195
Mondini dysplasia is rare, but has an important association with recurrent bacterial meningitis. We herein describe the case of a 3‐year‐old girl with unilateral sensorineural hearing loss who presented with three independent episodes of bacterial meningitis within 8 months. Temporal bone computed tomography indicated the characteristic features of Mondini dysplasia in the right inner ear. This was treated by surgical closure of the inner ear defect via oval window and additional vaccination was administered. Appropriate vaccination might prevent the recurrent bacterial meningitis associated with Mondini dysplasia. 相似文献
102.
Hidenori Moriyama Mitsushige Murata Toshimitsu Tsugu Takashi Kawakami Masaharu Kataoka Takahiro Hiraide Mai Kimura Sarasa Isobe Jin Endo Takashi Kohno Yuji Itabashi Keiichi Fukuda 《The international journal of cardiovascular imaging》2018,34(6):875-882
Chronic thromboembolic pulmonary hypertension (CTEPH) has a poor prognosis because of the associated progressive right heart failure. Accurate evaluation of right ventricular (RV) function would thus be useful to predict prognosis. However, the significance of RV diastolic function remains unclear. We aimed to identify which echocardiographic measures are most accurate, and potentially useful, in assessing RV diastolic function in patients with CTEPH, and to study the effects of balloon pulmonary angioplasty (BPA) on them. We enrolled 53 CTEPH patients who underwent BPA. Echocardiographic parameters, including two-dimensional speckle-tracking echocardiography, were compared to the hemodynamic parameters measured by right heart catheterization before and after BPA. RV strain rate during early diastole (SR_E), tricuspid e′ and right atrial area (RAA) were ameliorated after BPA, concomitant with a decrease in the time constant of the RV pressure curve during diastole (tau), indicating the improvement of RV diastolic function. Among them, SR_E had the strongest correlation with tau (r?=???0.39, p?<?0.001). Furthermore, the receiver operating characteristic analyses revealed that E/SR_E (AUC 0.704) and inferior vena cava diameter (AUC 0.726) had a stronger association with higher mean right atrial pressure than RAA (AUC 0.632). In contrast, RAA had a stronger correlation with 6 min-walk distances than SR_E (r?=???0.39, p?<?0.001 vs. r?=?0.30, p?=?0.005). Taken together, echocardiographic assessment of RV diastolic function might be associated with hemodynamics as well as exercise tolerance in patients with CTEPH, indicating its benefits in evaluating the therapeutic effects of BPA. 相似文献
103.
104.
Microvascular resistance in response to iodinated contrast media in normal and functionally impaired kidneys
下载免费PDF全文
![点击此处可从《Clinical and experimental pharmacology & physiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Osamu Kurihara Masamichi Takano Saori Uchiyama Isamu Fukuizumi Tetsuro Shimura Masato Matsushita Hidenori Komiyama Toru Inami Daisuke Murakami Ryo Munakata Takayoshi Ohba Noritake Hata Yoshihiko Seino Wataru Shimizu 《Clinical and experimental pharmacology & physiology》2015,42(12):1245-1250
Contrast‐induced nephropathy (CIN) is considered to result from intrarenal vasoconstriction, and occurs more frequently in impaired than in normal kidneys. It was hypothesized that iodinated contrast media would markedly change renal blood flow and vascular resistance in functionally impaired kidneys. Thirty‐six patients were enrolled (32 men; mean age, 75.3 ± 7.6 years) undergoing diagnostic coronary angiography and were divided into two groups based on the presence of chronic kidney disease (CKD), defined as an estimated glomerular filtration rate (eGFR) of < 60 mL/min per 1.73 m2 (CKD and non‐CKD groups, n = 18 in both). Average peak velocity (APV) and renal artery resistance index (RI) were measured by Doppler flow wire before and after administration of the iodinated contrast media. The APV and the RI were positively and inversely correlated with the eGFR at baseline, respectively (APV, R = 0.545, P = 0.001; RI, R = ?0.627, P < 0.001). Mean RI was significantly higher (P = 0.015) and APV was significantly lower (P = 0.026) in the CKD than in the non‐CKD group. Both APV (P < 0.001) and RI (P = 0.002) were significantly changed following contrast media administration in the non‐CKD group, but not in the CKD group (APV, P = 0.258; RI, P = 0.707). Although renal arterial resistance was higher in patients with CKD, it was not affected by contrast media administration, suggesting that patients with CKD could have an attenuated response to contrast media. 相似文献
105.
Sakamoto Kazumasa Ito Kiyoaki Yotsuyanagi Hiroshi Yatsuhashi Hiroshi Tanaka Yasuhito Hige Shuhei Takikawa Yasuhiro Ueno Yoshiyuki Yamamoto Kazuhide Imazeki Fumio Inoue Jun Kurosaki Masayuki Umemura Takeji Toyoda Hidenori Mita Eiji Michitaka Kojiro Maeshiro Tatsuji Yamada Norie Suetsugu Atsushi Kawanaka Miwa Seko Yuya Matsuura Kentaro Okumura Akinori Fukuzawa Yoshitaka Sugiyama Masaya Mizokami Masashi Yoneda Masashi 《Journal of gastroenterology》2022,57(12):971-980
Journal of Gastroenterology - Hepatitis B virus (HBV) is one of the most prevalent chronic viral infections that causes chronic hepatitis B (CHB). In Japan, genotypes B and C account for most of... 相似文献
106.
Kobayashi Toshikazu Omori Yuko Ono Yusuke Karasaki Hidenori Mizukami Yusuke Makino Naohiko Motoi Fuyuhiko Unno Michiaki Ueno Yoshiyuki Furukawa Toru 《Journal of gastroenterology》2021,56(6):581-592
Journal of Gastroenterology - Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is categorized into four distinct types: the gastric, intestinal, pancreatobiliary, and oncocytic. Each... 相似文献
107.
Ishida Atsushi Shichi Hiroki Fukuoka Hidenori Inoshita Naoko Ogawa Wataru Yamada Shozo 《Pituitary》2022,25(2):238-245
Pituitary - Refractory prolactinomas resistant to dopamine agonists (DAs) pose a clinical challenge. Temozolomide (TMZ) is a recommended treatment option, but its effects are difficult to predict,... 相似文献
108.
Non-hypervascular hypointense nodules (NHHNs) on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid–enhanced magnetic resonance imaging (EOB-MRI) have a high likelihood of hypervascularization progressing to typical hypervascular hepatocellular carcinoma (HCC). NHHNs that were present before the start of anti-hepatitis C virus (HCV) therapy is a risk marker for HCC development after achieving sustained virologic response (SVR). In this report, we show a patient without a previous history of HCC in whom HCC developed by hypervascularization of NHHN after SVR. This patient achieved SVR more than 8 years before NHHN developed into HCC, and during this time NHHN had been present but had remained unchanged in size and imaging features as shown by repeated EOB-MRI. Hepatocarcinogenic potential of NHHNs persist for a long time after SVR, despite the eradication of HCV. 相似文献
109.
Toyoda H Kumada T Nakano S Takeda I Sugiyama K Kiriyama S Tanikawa M Sone Y Hisanaga Y Hayashi K 《Hepato-gastroenterology》2002,49(48):1619-1624
BACKGROUND/AIMS: To evaluate efficacy of high-intensity interferon administration for patients chronically infected with hepatitis C virus genotype 1b, we administered interferon-alpha with different regimens according to viral load. METHODOLOGY: Eighty-eight patients with hepatitis C virus genotype 1b were treated with recombinant interferon alpha-2b. The 70 patients with pretreatment hepatitis C virus RNA concentration > or = 10(6) copies/mL were given 10(7) units of interferon daily for the first 8 weeks and then three times weekly for 16 weeks (group A). The 18 patients with smaller pretreatment hepatitis C virus RNA concentration received the same dose daily for the first 2 weeks and then three times weekly for 14 weeks (group B). We analyzed tolerance of therapy, responses, and long-term outcome in the two groups. RESULTS: Fifteen of 70 patients (21.4%) in group A could not continue treatment and dropped out, while all patients in group B completed the entire course of therapy. The rate of sustained response in group A was 10.0%, being significantly less than in group B (72.2%; p < 0.0001). However, 12 patients in group A showed a biochemical sustained response despite presence of viremia. Long-term outcome did not differ between groups. CONCLUSIONS: Many patients could not tolerate high-intensity therapy, which showed the limitation of tolerance of patients receiving interferon monotherapy. High-intensity therapy could not improve eradication of hepatitis C virus in patients with high pretreatment hepatitis C virus RNA concentration. However, this therapy may increase the rate of sustained biochemical response, improving long-term outcome. 相似文献
110.
Matsumoto M Zhou Y Matsuo S Nakanishi H Hirose K Oura H Arase S Ishida-Yamamoto A Bando Y Izumi K Kiyonari H Oshima N Nakayama R Matsushima A Hirota F Mouri Y Kuroda N Sano S Chaplin DD 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(18):6720-6724
Controlled proteolytic degradation of specialized junctional structures, corneodesmosomes, by epidermal proteases is an essential process for physiological desquamation of the skin. Corneodesmosin (CDSN) is an extracellular component of corneodesmosomes and, although considerable debate still exists, genetic studies have suggested that the CDSN gene in the major psoriasis-susceptibility locus (PSORS1) may be responsible for susceptibility to psoriasis, a human skin disorder characterized by excessive growth and aberrant differentiation of keratinocytes. CDSN is also expressed in the inner root sheath of hair follicles, and a heterozygous nonsense mutation of the CDSN gene in humans is associated with scalp-specific hair loss of poorly defined etiology. Here, we have investigated the pathogenetic roles of CDSN loss of function in the development of skin diseases by generating a mouse strain with targeted deletion of the Cdsn gene. Cdsn-deficient mouse skin showed detachment of the stratum corneum from the underlying granular layer and/or detachment within the upper granular layers due to the disrupted integrity of the corneodesmosomes. When grafted onto immunodeficient mice, Cdsn-deficient skin showed rapid hair loss together with epidermal abnormalities resembling psoriasis. These results underscore the essential roles of CDSN in hair physiology and suggest functional relevance of CDSN gene polymorphisms to psoriasis susceptibility. 相似文献