全文获取类型
收费全文 | 1155篇 |
免费 | 67篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 40篇 |
妇产科学 | 6篇 |
基础医学 | 120篇 |
口腔科学 | 51篇 |
临床医学 | 97篇 |
内科学 | 301篇 |
皮肤病学 | 43篇 |
神经病学 | 51篇 |
特种医学 | 163篇 |
外国民族医学 | 1篇 |
外科学 | 117篇 |
综合类 | 40篇 |
预防医学 | 61篇 |
眼科学 | 17篇 |
药学 | 59篇 |
中国医学 | 1篇 |
肿瘤学 | 40篇 |
出版年
2022年 | 5篇 |
2021年 | 6篇 |
2020年 | 6篇 |
2019年 | 13篇 |
2018年 | 14篇 |
2017年 | 20篇 |
2016年 | 23篇 |
2015年 | 38篇 |
2014年 | 25篇 |
2013年 | 41篇 |
2012年 | 44篇 |
2011年 | 46篇 |
2010年 | 41篇 |
2009年 | 58篇 |
2008年 | 46篇 |
2007年 | 37篇 |
2006年 | 32篇 |
2005年 | 43篇 |
2004年 | 51篇 |
2003年 | 30篇 |
2002年 | 27篇 |
2001年 | 17篇 |
2000年 | 17篇 |
1999年 | 27篇 |
1998年 | 61篇 |
1997年 | 64篇 |
1996年 | 57篇 |
1995年 | 42篇 |
1994年 | 40篇 |
1993年 | 37篇 |
1992年 | 10篇 |
1991年 | 11篇 |
1990年 | 16篇 |
1989年 | 17篇 |
1988年 | 23篇 |
1987年 | 23篇 |
1986年 | 21篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1983年 | 8篇 |
1982年 | 19篇 |
1981年 | 4篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1972年 | 3篇 |
1968年 | 4篇 |
1959年 | 2篇 |
排序方式: 共有1232条查询结果,搜索用时 15 毫秒
31.
32.
Early detection of synovitis in rheumatoid arthritis (RA) and distinction from osteoarthritis (OA) are important to establish the most appropriate treatment. Increased perfusion over affected joints observed by laser Doppler perfusion imaging was supposed to arise from the underlying joint, because it was detected only by a near-infrared laser and not by a less penetrating red laser source. Using laser Doppler anemometry, this study addressed two questions: (1) whether capillary blood cell velocity (CBV) is increased in the skin over finger joints affected by RA or OA; (2) whether there is a difference between RA and OA in CBV above affected proximal interphalangeal (PIP) joints. Levels of soluble adhesion molecules were measured, because they indicate rheumatoid vasculitis raising flow resistance. Thirty-one patients with RA and 20 with OA were investigated. Compared to 18 controls, CBV (mean+/-SEM) was elevated above PIP joints clinically affected by RA (0.35+/-0.06 mm/s vs. 0.21+/-0.02 mm/s; P<0.05) and over PIP (0.27+/-0.02 mm/s vs. 0.21+/-0.02 mm/s; P<0.05) and distal interphalangeal joints (0.27+/-0.02 mm/s vs. 0.17+/-0.01 mm/s; P<0.001) affected by OA. Levels of soluble adhesion molecules were not correlated with CBV over PIP joints in RA. These observations demonstrated that elevated blood cell velocity is detectable by laser Doppler anemometry in skin capillaries over interphalangeal joints affected by RA or OA and contradict the previous assumption that there is hyperemia only in the affected joint. The lack of a significant difference in CBV over PIP joints between RA and OA patients might be due to some inflammation also occurring in OA rather than to vasculitic processes in RA associated with elevated levels of soluble adhesion molecules. 相似文献
33.
34.
35.
36.
The relative importance of thrombin inhibition and factor Xa inhibition to the antithrombotic effects of heparin 总被引:4,自引:1,他引:4
The relative importance of antithrombin and anti-factor Xa activities of heparin fractions required to achieve optimal antithrombotic effects is unknown. To study this, we measured the effects of standard heparin, an octasaccharide heparin fraction (anti-factor Xa activity only), and dermatan sulfate (antithrombin activity only) on the prevention of thrombosis and related this to their anticoagulant effects in vivo in rabbits. Thrombosis was measured as the incorporation of 125I- fibrinogen into tissue thromboplastin-induced thrombi using a Wessler- type model. Ex vivo changes in thrombin clotting time (TCT) were used as an index of antithrombin activity, and a chromogenic anti-factor Xa assay was used to measure anti-factor Xa activity. In addition, the ability of the three sulfated polysaccharides to simultaneously inhibit the generation of thrombin activity and to enhance the inactivation of the factor Xa added to initiate thrombin generation in plasma was determined. Standard heparin, in a dose of 10 anti-factor Xa U/kg, inhibited thrombus formation by 90%, prolonged the TCT by two seconds, and resulted in an anti-factor Xa level of 0.32 U/mL. The octasaccharide heparin fraction, in a dose of 10 anti-factor Xa U/kg, inhibited thrombus formation by 41%, had no effect on the TCT, and resulted in an anti-factor Xa level of 0.28 U/mL. Higher doses of the octasaccharide resulted in a further increase in the anti-factor Xa levels but had no further effect on thrombus formation. Dermatan sulfate, in a dose of 500 micrograms/kg, inhibited thrombus formation by 95%, but had no affect on the TCT. These results indicate that the antithrombotic effect achieved by inhibiting factor Xa is limited and that better antithrombotic effects are achieved by heparin or heparin- like substances capable of influencing the inactivation and/or the generation of thrombin. 相似文献
37.
38.
39.
A Bahrami Y Rassi N Maleki MA Oshaghi M Mohebali MR Yagoobi-Ershadi S Rafizadeh 《亚太热带病杂志(英文版)》2014,4(2):110-114
Objective
To identify the vector(s), the parasite and the species composition of sand flies in the district during May-October 2012.Methods
For reaching our objectives we used polymerase chain reaction of kDNA, ITS1-rDNA, followed by restriction fragment length polymorphism.Results
Two species of Phlebotomus sergenti and Phlebotomus tobbi were the most prevalent among 8 species identified comprising 51.1% and 32.9% respectively. Among the 160 specimens of female sand flies tested by polymerase chain reaction of kDNA, ITS1-rDNA, followed by restriction fragment length polymorphisms, only 1 out of 80 Phlebotomus tobbi (1.25%) were positive to Leishmania infantum parasites.Conclusions
Our finding showed that Phlebotomus tobbi may play as a vector to circulate the parasite of Leishmania infantum among reservoir(s) and human. 相似文献40.