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101.
Increased frequency of congenital chromosomal aberrations in female partners of couples undergoing intracytoplasmic sperm injection 总被引:3,自引:7,他引:3
van der Ven K; Peschka B; Montag M; Lange R; Schwanitz G; van der Ven HH 《Human reproduction (Oxford, England)》1998,13(1):48-54
We evaluated the frequency of congenital chromosomal aberrations in a
sample of 305 couples included in an intracytoplasmic sperm injection
(ICSI) programme. Twenty individuals (3.3%) with congenital chromosomal
abnormalities could be identified. The following types of abnormalities
were observed: reciprocal translocations (n = 7), Robertsonian
translocations (n = 3), inversions (n = 3), other structural aberrations (n
= 4) and sex chromosome aberrations (n = 3). The rate of chromosomally
abnormal males (10/305, 3.3%) lay within the expected range for patients
with reduced semen quality. Surprisingly, 50% (10/20) of all abnormal
karyotypes were contributed by the female partner of ICSI patients. These
data confirm the higher incidence of chromosomal aberrations in infertile
populations as compared with the baseline population risk. Additionally,
the data imply that in some cases of male factor infertility a hidden
female chromosomal factor may be present, which cannot be identified by
standard clinical evaluation. In conclusion, we recommend chromosomal
analysis in both partners of couples undergoing ICSI treatment.
相似文献
102.
103.
Smets YF; van der Pijl JW; van Dissel JT; Ringers J; de Fijter JW; Lemkes HH 《Nephrology, dialysis, transplantation》1997,12(4):764-771
BACKGROUND: Although technical success rate of simultaneous pancreas kidney
(SPK) transplantation in insulin-dependent diabetes mellitus (IDDM)
patients with diabetic nephropathy has improved, morbidity remains high due
to infection and rejection. The purpose of this study was to analyse
infections encountered in our series of SPK transplants, using a
restrictive antibiotic prophylaxis policy. METHODS: We reviewed all
infectious diseases after 66 consecutive bladder-drained SPK
transplantations in 64 IDDM patients with end-stage renal disease due to
diabetic nephropathy. During follow-up, the perioperative antibiotic
regimen was altered (from 5 days preemptive therapy with multiple drugs to
1 day prophylaxis with cefamandole), and long-term viral prophylaxis
(high-dose aciclovir) was introduced. For post-operative urinary tract or
opportunistic infection, no prophylaxis was given. RESULTS: Overall mean
infection rate was 2.9 infections/ patient/year after a mean follow-up of
2.3 years. Surgical site infections (SSI) were seen in 30% of the patients,
with Enterococci present in 47%. Logistic regression showed one day
cefamandole prophylaxis to be associated with SSI, but there was no
significant influence of SSI on either graft or patient survival.
Forty-eight percent of all infections were lower urinary tract infections
(UTI). There were 59 first UTIs (89%), probably related to long-term Foley
catheter use, and 47 second UTIs (71%). Subsequent UTIs were not
microbiologically related to first UTIs. Cytomegalovirus (10 patients) and
other opportunistic agents did not cause mortality or graft loss. Five
grafts were lost due to infection (SSI three times, post-transplant
lymphoproliferative disease twice). Only one patient died because of
infection (2%). CONCLUSIONS: Infectious diseases after SPK transplantation
caused significant morbidity but did not influence either patient or graft
survival. A change in prophylactic policy for both SSI as well as recurrent
UTI, combined with earlier Foley removal, may lower incidences of these
infections.
相似文献
104.
Congenital cardiomyopathy and cataracts with lactic acidosis 总被引:4,自引:0,他引:4
J Valsson T Laxdal A Jonsson K K Jansson H Helgason 《The American journal of cardiology》1988,61(1):193-194
105.
HH Murphy A Bari AM Molla A Zaidi N Hirschhorn 《Acta paediatrica (Oslo, Norway : 1992)》1996,85(2):151-157
A total of 326 Afghan children aged between 6 months and 5 years with uncomplicated nondysenteric diarrhea for the previous 24 h to 5 days were treated at home by their mothers with either wheat-salt solution (WSS) or World Health Organization recommended glucose-oral rehydration salts (G-ORS). For 7 consecutive days the children were examined in the household and the mothers interviewed to assess the progress, feeding practices, and perception of treatment efficacy. Children treated with WSS recovered significantly earlier; the mean duration on treatment was 4.0 days (SD 1.7 days) on WSS compared to 6.4 days (SD 1.7 days) on G-ORS. By the second day of treatment, significantly more mothers using WSS (56%) reported that their children had formed stools versus 11 % of their G-ORS counterparts; the mean stool frequency after 2 days was also significantly reduced; 3 stools day−1 (SD 2.1) on WSS versus 5 (SD 2.9) on G-ORS. The cereal-based solution was not confused with normal food and led to better feeding patterns. By day 2, 74% of the mothers using WSS had resumed their normal feeding frequencies as opposed to 33% of G-ORS mothers. On recovery the WSS group had gained significantly more weight; the WSS group gained 169 g (SD 142 g) while the G-ORS group lost 150g (SD 174 g). This study suggests by subjective and objective measures that WSS could be considered as an effective home fluid for the first-line treatment of diarrhea. 相似文献
106.
107.
Granulocytic sarcoma (chloroma): CT manifestations 总被引:2,自引:0,他引:2
Nests of granulocytic tumor cells in patients who have myelogenous leukemia are termed chloromas. Eight cases of chloroma seen on CT were reviewed. Lymph nodes, subcutaneous tissues, peritoneum, pleural space, pelvis, and portal hepatis were involved. Two patients exhibited chloroma as the sole manifestation of their disease during bone marrow remission. The extracranial appearance of chloroma on CT is that of small, nonenhancing, nodular densities that resemble lymphoma. Cranial involvement is characteristically in the orbit. The central nervous system appearance is variable, however, and high attenuation masses may occur that mimic lymphoma, hematoma, and metastatic neuroblastoma. The recognition of these lesions is important, since radiation, not chemotherapy, is often the preferred treatment for localized chloroma. 相似文献
108.
An epidemiological study of Sonne dysentery in Dundee during the years 1971-6 was made by examining, in respect of 1420 isolates of Shigella sonnei, the discriminating power of colicine typing, antibiogram testing, biotyping and resistotyping and the stabilty of the markers they provided. Colicine typing identified nine colicine types, including four not previously described. However, because types 4 and 4 var., determined by col Ib, and type U, producing no colicines, accounted for 96% of the isolates, discrimination with colicine typing was poor. In antibiotic sensitivity test, 13 different antibiogram patterns were noted. Less than 1% of the isolates were sensitive to all of the eight antibiotics tested; most were multiply drug-resistant. Resistance to kanamycin, neomycin and paromomycin (KNP) was apparently due to a single resistance determinant, widely distributed in a majority (53%) of the isolates. When definitive times were chosen for reading each biotyping test, only maltose and rhamnose of the 13 "sugars'' tested differentiated isolates into prompt- and late-fermenting types. Though the ability to ferment rhamnose was a stable property, it discriminated only 1.5% of the minority, late-fermenting type. Resistotyping with six chemicals discriminated eight epidemiologically valid resistotypes, including three new types. However, 93 of the isolates belonged to only three resistotypes. Analysis of the data for isolated from 286 epidemiologically distinct episodes showed that the variability of colicine and antibiogram characters, found among isolates within, respectively, 40 and 28% of the episodes, was generally associated with loss or gain of a plasmid ("col Ib-KNP'') which determined production of colicine Ib and KNP resistance. These characters varied both in vivo and in vitro. Variability of resistotype characters, on the other hand, was observed in only 28 (9%) episodes, 14 of which possibly represented examples of mixed or sequential infections. For accurate epidemiological tracing of strains of Sh. sonnei in a community, resistotyping, the technique showing the greatest discrimination and least variability of the four tested, should be included as the principal typing method. 相似文献
109.
A new type of delta beta-thalassemia characterized by decreased expression of the beta-globin gene and increased expression of both G gamma and A gamma globin gene in the absence of a detectable deletion has recently been described in the Chinese population. In this study we characterize the mutant beta-globin gene from this delta beta- thalassemia chromosome. An A to G transversion is identified in the "ATA" sequence of the promoter region that leads to decreased expression of the beta-globin gene in vivo and in vitro. We also demonstrate the presence of this mutation in every individual with a high fetal hemoglobin phenotype in this family and its absence in every individual with a normal hemoglobin phenotype. This same promoter mutation has recently been detected in Chinese beta-thalassemia genes where it is present on chromosomes of the same haplotype as that of the delta beta-thalassemia chromosome we are studying. These data support the hypothesis that an as yet unidentified mutation occurred on the ancestral chromosome carrying the promoter mutation and subsequently gave rise to the delta beta-thalassemia phenotype. 相似文献
110.
C M Helgason 《The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques》1987,14(4):560-563
A 17th century B.C. Surgical Papyrus known as "The Edwin Smith Papyrus" was published in facsimile and hieroglyphic transliteration with translation and commentary by James Henry Breasted in 1930. The Papyrus was acquired by Edwin Smith in Luxor, 1862. This document was conceived in the Pyramid Age (3000-2500 B.C.) and remains in material form from the 17th century B.C. It is of importance to the history of Neurology as it contains the earliest mention in oriental literature of (a) the brain and meninges (b) calvarial and cervical vertebral injuries in details of pathology, symptomatology, treatment and prognosis and (c) functional localization in the brain and spine. Most importantly, Papyrus Smith is a statement of the medical ethic of its time. 相似文献