Hepatocellular carcinoma not associated with cirrhosis. A clinicopathological study in 41 patients including 29 resected cases

Abstract Clinicopathological features were studied in 41 patients with histology-proven hepatocellular carcinoma without cirrhosis. Of these, 13 (31.7%) were positive for hepatitis B virus surface antigen (HBsAg) and 28 were negative. Twenty-six of 28 (92.9%) HBsAg negative cases had anticore antibody (anti-HBc) of low titres. The age of patients at the time of diagnosis of hepatocellular carcinoma was significantly younger in the HBsAg positive cases compared with the negative. The initial diagnostic clue was either abdominal mass or abdominal pain in 18 (43.9%) patients. However, the number of patients in whom hepatocellular carcinoma was detected by imaging in the absence of such clinical signs has increased recently. The tumour was encapsulated in 31 cases (75.6%) and most solitary encapsulated tumours were growing expansively. Tumours were resectable in 29 (70.7%) cases, and the prognosis of resected cases was much better than that of 12 non-operated cases. Twenty-one out of 29 (72.4%) resected tumours were solitary and encapsulated. However, recurrence of tumour occurred in 12 out of 28 (42.9%) cases, and it was within 2 years of resection in 11 cases. These observations and data seem to indicate that early detection and resection of tumour is very important in management, but tumour recurrence is inevitable in a considerable proportion of the patients with non-cirrhotic hepatocellular carcinoma.     

Porosity in microfill restorative composites cured by visible light

Abstract – Previous studies indicate that porosity in dental microfill composite restoratives reduces the clinical qualities of this group of materials. Porosity may decrease the optical quality of restorations and is probably a strong factor in reducing wear resistance of Class 1 fillings. In view of possibly eliminating this disturbing factor it was the purpose of the present work to study the effect of variables in the clinical technique on porosity. Initially it was found that filling by spatula as well as paste-paste mixing of non-porous microfill materials caused high porosity, and that the visible light curing microfill brands studied were pore-free as delivered by manufacturers. Consequently only this type of material was studied in detail and only when applied by syringing technique. Poor adaptation of composite to tube inside and to cavity walls as well as too small diameter of the tube tip were found to be factors greatly adding to porosity. In cylindrical cavities, 3 mm in diameter and 2 mm deep, porosity could be consistently reduced to zero by wetting the inside of the tube as well as the cavity walls by a drop of visible light curing monomer and by use of tube with a tip opening of 1.0 mm. Similar positive results were obtained for simulated Class 1 fillings. No adverse effects of this technique were found.     

双氯芬酸对脂多糖诱发脑内核团Fos表达的影响

目的 观察双氯芬酸对脂多糖(LPS)免疫应激时大鼠下丘脑室旁核(PVN)、视上核(SON)及脑干蓝斑(LC)中Fos表达的影响.方法大鼠随机分成正常对照组、模型组、双氯芬酸实验组(5,20mg/kg),利用Fos蛋白、加压素(AVP)和酪氨酸羟化酶(TH)双重免疫组织化学方法,定位并检测上述核团中Fos阳性神经元的数目,并进行统计学分析.结果 与对照组比较,腹腔注射LPS明显诱发PVN、SON和LC出现大量Fos样免疫反应神经元(P＜0.01),Fos-AVP、Fos-TH双标神经元明显增加;双氯芬酸能剂量依赖地降低LPS诱导的Fos阳性神经元数目.结论 双氯芬酸下调不同脑区LPS免疫应激Fos蛋白的表达与其抑制PGs的合成有关,通过下调下丘脑-垂体-肾上腺皮质(HPA)轴的活动,从而发挥中枢应激调节作用.     

A Preliminary Report of Phase I and II Study of N4-Behenoyl-1-{beta}-D-arabinofuranosylcytosine (BH-AC) in Patients with Acute Leukemia and Other Malignancies

N⁴-Behenoy1-1-ß-D-arabinofuranosy1cytosine (BH-AC)was administered to 11 patients with acute leukemia and fivepatients with other malignancies in a Phase I and TI clinicaltrial. Among 16 patients, 14 received BH-AC after being refractoryto prior therapies, and two with acute leukemia received BH-ACfor their first remission induction therapy. The starting dose was 1.5mg/kg administered as a single i.v.infusion of three hours. The doses were then escalated up to5.0 mg/kg. No side effects were noted with single i.v. infusions.Daily consecutive infusions of 2.0 mg to 6.0 mg/kg for fourto 21 days resulted in two patients experiencing nausea, twoanorexia and one developing skin eruptions. Significant hematologicaleffects were noted by the daily infusions. One patient withacute myeloblastic leukemia achieved complete remission with5.0 mg/kg BH-AC administered daily for 21 days. BH-AC is active in acute leukemia and may play a role in thecombination regimens for this disease.     

Acute pancreatitis complicating typhoid fever in a 4-year-old girl

Pancreatitis represents an extremely rare complication of typhoid fever. Herein we report the case of a 4-year-old Bangladeshi girl with acute pancreatitis caused by Salmonella typhi.     

灯笼草镇痛作用及其机理的研究

目的：观察灯笼草的镇痛作用。方法：采用扭体法、电刺激鼠尾－嘶叫法、钾离子透入法和辐射热－缩腿法等行为学指标以及丘脑束旁核神经元对伤害性刺激的放电反应的电生理指标。结果：灯笼草能剂量依赖地提高大鼠电刺激鼠尾－嘶叫法的痛阈,剂量依赖地抑制醋酸引起的小鼠扭体反应,对炎症性痛敏及神经源性痛敏灯笼草也有镇痛作用,灯笼草还能明显抑制丘脑束旁核神经元对伤害性刺激的放电反应。纳洛酮能翻转灯笼草的镇痛作用,反复给予灯笼草能产生耐受,但与吗啡镇痛之间不存在交叉耐受。结论：灯笼草具有镇痛作用,其镇痛作用可能涉及中枢阿片受体。