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Über die monoaminergischen Systeme des Gehirns in Beziehung zur Ejakulation III. Weitere Untersuchung unter Vetwendung eines peripheren Decarboxylase-Inhibitors
In den vorausgegangenen Arbeiten war berichtet worden, daß die Ejakulation erleichtert wird durch das dopaminergische System des Gehirns, teilweise über den vorderen Hypothalamus und daß die Ejakulation durch das serotonergische System gehemmt wird. Auf dem Wege, diese Resultate praeziser zu klären wurden jetzt Untersuchungen durchgeführt, bei welchen Hunden ein peripherer Decarboxylase-Inhibitor (Ro 4–4602) in Kombination mit Tetrabenazin und L-dopa verabfolgt wurde. Es kann gezeigt werden, daß zusätzlich zu dem dopaminergischen System des Gehirns der Anstieg des Serotoninwertes im limbischen System und der Abfall des Serotininspiegels im Stammhirn die Ejakulation erleichtert. 相似文献
In den vorausgegangenen Arbeiten war berichtet worden, daß die Ejakulation erleichtert wird durch das dopaminergische System des Gehirns, teilweise über den vorderen Hypothalamus und daß die Ejakulation durch das serotonergische System gehemmt wird. Auf dem Wege, diese Resultate praeziser zu klären wurden jetzt Untersuchungen durchgeführt, bei welchen Hunden ein peripherer Decarboxylase-Inhibitor (Ro 4–4602) in Kombination mit Tetrabenazin und L-dopa verabfolgt wurde. Es kann gezeigt werden, daß zusätzlich zu dem dopaminergischen System des Gehirns der Anstieg des Serotoninwertes im limbischen System und der Abfall des Serotininspiegels im Stammhirn die Ejakulation erleichtert. 相似文献
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HIDEAKI KIM HIDEO YAMAGUCHI KOJI INAMO TOMOO OKADA KENSUKE HARADA 《Pediatrics international》1995,37(6):672-676
To determine disturbances of lipid metabolism in patients with Kawasaki disease, we investigated changes in the serum levels of apolipoproteins and serum lipids. Results were as follows. Total serum cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) decreased during the early stage of Kawasaki disease. The apo A-I and A-II levels were low until the 2nd week of illness. Apo B decreased during the 1st week of illness, but rose slightly during the 2nd and 3rd weeks. The apo B/apo A-I ratio and the apo B/TC ratio were high in the early stages of illness. The group of patients with coronary artery lesions showed low levels of TC and HDL-C, and low levels of apo A-I, A-II and B during the early stages, compared with the group without coronary artery lesions. The apo B/TC ratio was significantly higher in the patients with coronary artery lesions during the 2nd week of illness. Our findings suggest an association between changes in serum lipids and apolipoproteins and coronary artery involvement in Kawasaki disease. These abnormalities may indicate the presence of early coronary arteriosclerosis. 相似文献
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RYOJI KISHI NAOKI MATSUMOTO† KIYOSHI NAKAZAWA AKIHIKO TAKAGI TSUNEHARU SAKURAI TOSHIHIKO NANKE YOSHIYUKI WATANABE OSAMU MIYAZU TOMOO HARADA SHINICHI KOBAYASHI† FUMIHIKO MIYAKE 《Pacing and clinical electrophysiology : PACE》2003,26(1P2):527-529
KISHI, R., et al.: Influence of Mobile Magnetic Resonance Imaging on Implanted Pacemakers. Purpose: Mobile magnetic resonance imaging (MRI) systems will be widely used in Japan. When traveling, mobile MRI generate alternating electromagnetic waves which may cause electromagnetic interference (EMI). This study was designed to determine whether this may influence the function of implanted pacemakers (PM). Methods and Results: The influence of the static magnetic fields was tested in the first method using a PM-human model (Phantom). Magnetic force was simultaneously measured. The PM was switched to the magnet mode within 90 cm from the vehicle, where the magnetic force was = 2 mT. In the second method, six phantoms were placed on the side of the road, facing in three different directions in X-Y-Z axis orientations, at 1.3 m and 2.0 m above the ground. The mobile MRI passed by at a distance of 1 m from the phantoms at the speed of 20 or 40 km/h. In these experiments, magnet mode switch of the PM was observed for 2 seconds when the vehicle passed close to the phantoms, though no electrical noise was recorded. Conclusion: Mobile MRI vehicles can switch a PM to magnet mode when the distance between patient and vehicle is <90 cm, regardless of whether the vehicle is moving or at a stop. Patients with implanted PM should not approach within <1 m of a mobile MRI. No other EMI-induced PM dysfunction was detected. (PACE 2003; 26[Pt. II]:527–529) 相似文献
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FUMIO SUZUKI TOMO-O HARADA TOKUHIRO KAWARA KAZUSHI TANAKA KENZO HIRAO KAZUMASA HIEJIMA MICHAEL H. LEHMANN 《Pacing and clinical electrophysiology : PACE》1993,16(10):1994-2006
Studies in humans have found left atrial stimulation via the coronary sinus (CS) to elicit significantly shorter atrium-His (AH) intervals as compared to right atrial stimulation, but whether pacing at dijferent left atrial sites (anterior vs posterior left atrium, i.e., far distal vs proximal CSJ affects the AH interval has not been studied. Hence, in 22 patients, we compared the effects of stimulation from various atriai sites, including anterior high right atrium (HRA), distal CS, mid-CS, and proximal CS, on; stimulus-atrium (SA), AH, and stimuIus-His intervals on the His bundle electrogram. Paced cycle length differed for each patient (range 900–350 msec, mean 532 ± 140 msec), but conduction intervals from different atrial sites were compared using identical cycle length in each patient. The mean SA intervals were 34 ± 10 msec, 57 ± 10 msec, 44 ± 11 msec, and 32 ± 8 msec with stimulation, respectively, from HRA, distal CS, mid-CS. and proximal CS (each significantly different except for HRA vs proximal CSJ. The mean AH intervals were 123 ± 23 msec, 104 ± 28 msec, 95 ± 15 msec, and 90 ± 18 msec with stimulation, respectively, from HRA, distal CS, mid-CS, and proximal CS (each significantly different except for mid-CS vs proximal CSJ. In 13 patients, the discrepancy in AH intervals during distal versus proximal CS stimulation was > 15 msec; in 9 patients this difference was only < 10 msec, considered within the range of measurement error. Thus, in a significant portion of patients, discrepant AH intervals were demonstrated during stimulation from the distal versus proximal CS. These previously undescribed observations suggest that electrophysiological studies on atrioventricular nodal conduction that involve left atrial stimulation must take into account actual location of the stimulation site (anterior or posterior) in order to properly interpret the findings. 相似文献
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SHIGEHARU HOSONO TSUTOMU OHNO HIROFUMI KIMOTO MASAKI SHIMIZU KENSUKE HARADA 《Pediatrics international》2006,48(1):33-39
BACKGROUND: The purpose of the present paper was to evaluate the mortality and morbidity of infants born at 22-24 weeks gestation. METHODS: A total of 78 infants born at 22-24 weeks gestation, who were admitted between January 1991 through December 2000, were retrospectively studied. RESULTS: Seventy-one of 78 infants were enrolled in the present study. One year survival rates at 22, 23 and 24 weeks were 40.0% (2/5), 61.1% (11/18), and 50.0% (24/48), respectively. Failure of response to surfactant and air leak were associated with death in infants born at 23 weeks gestation. Low Apgar score, intraventricular hemorrhage (> or =III), and sepsis were correlated with death in infants born at 24 weeks gestation. The handicap rates of survivors born at 22, 23, and 24 weeks gestation were 100, 36.4, and 26.1%, respectively. CONCLUSIONS: The present study indicates that infants born at 22 weeks gestation, in whom pulmonary structure is established, that is, a viable lung that can exchange gas with exogenous surfactant, have a chance to survive, but neurological outcome is still poor. Every possible effort should be made to extend gestation beyond 22 weeks. 相似文献