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101.
Hans von Euler Harry Hellström Fritz Schlenk Gunnar Günther 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1939,140(1):116-128
Zusammenfassung In den untersuchten Augenlinsen (Rind, Ratte) fehlen die Oxydationskatalysatoren Cytochrom und Cytochromoxydase, ferner Diaphorase; Flavinenzym dürfte, falls überhaupt vorhanden, als Wasserstoffüberträger in Augenlinsen keine Rolle spielen.Unter den Dehydrasen fehlt die Succinodehydrase (vgl. S. 120). Eine größere Anzahl cozymasegebundener Dehydrasen ist nachgewiesen, ferner findet man die Codehydrase-II-spezifischen Dehydrasen der Hexose-mono-phosphorsäure.Die untersuchten Linsen sind reich an Cozymase und enthalten auch Codehydrase II; Cozymase ist in oxydierter und reduzierter Form (als Co und CoH2) vorhanden. Man findet also in den Linsen alle zurGlykolyse notwendigen enzymatischen Komponenten, während dasAtmungsystem unvollständig ist.Wie seit längerer Zeit bekannt ist, enthalten die Augenlinsen vielAscorbinsäure und vielSulfhydrylverbindungen (Thiole), welche als Aktivatoren bzw. Co-Enzyme eines noch unvollständig bekannten Enzymsystems der Oxydo-Reduktion in Betracht kommen.Für die Annahme, daß Ascorbinsäure in der Linse aus Hexosen entsteht, ließen sich experimentelle Anhaltspunkte gewinnen.Eine Reihe besonderer Versuche deutet darauf hin, daß SH-Verbindungen der Linsen imstande sind, Dehydroascorbinsäure zu reduzieren. 相似文献
102.
The increasing frequency and complexity of medical radiation exposures to humans inevitably result in higher risks of harmful unintended or accidental radiation exposures. To ensure a high level of protection and its continuous improvement, the Directive 2013/59/Euratom thus requires to systematically record and analyze both events and near-miss events as well as, in the case of their significance, to disseminate information regarding lessons learned from these events promptly and nationwide to improve radiation protection in medicine. These requirements have been transposed into German legislation by the new radiation protection law and radiation protection ordinance that entered into force simultaneously on December 31th, 2018. The reporting and information system as provided by these regulations as well as the tasks, duties and powers of the parties involved are presented in the first part of this review article. In the second part, the established application-specified criteria for the significance – and thus the notification requirement - of (near-miss) events are itemized and explicated. 相似文献
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104.
Prof. Dr. med. Uwe Janssens Prof. Dr. med. Hilmar Burchardi Univ.-Prof. Dr. med. Gunnar Duttge Renate Erchinger Dr. med. Peter Gretenkort Prof. Dr. med. Michael Mohr Univ.-Prof. Dr. med. Friedemann Nauck Sonja Roth?rmel Prof. Dr. med. Fred Salomon Univ.-Prof. Dr. med. P. Schmucker PD Dr. phil. Alfred Simon Prof. Dr. med. Herwig Stopfkuchen Prof. Dr. med. Andreas Valentin Univ.-Prof. Dr. med. Norbert Weiler Dr. med. Gerald Neitzke 《MedR Medizinrecht》2012,30(10):647-650
105.
Agneta Marcusson Thomas List Gunnar Paulin Ingemar Åkerlind 《Journal of plastic surgery and hand surgery》2013,47(3):271-278
The purpose of this study was to evaluate the reliability of a multidimensional questionnaire for Swedish adults with treated complete unilateral or bilateral cleft lip and palate (CLP). The questionnaire was designed to be used in the evaluation of adults with treated CLP after treatment. Before any conclusions were drawn from the results of the study we assessed the test-retest reliability of the questionnaire. The questionnaire included 168 questions and assessed the following domains: aesthetics, functions associated with CLP, satisfaction with treatment and perceived need for treatment, quality of life, depression and non-specific physical symptoms, body image, and jaw function. The subjects answered the questionnaire twice at a 2-3-week interval. Sixty-one adults (38 men, 23 women) mean age 24 years (range 20-29) participated in the study. The response rate for the questionnaire was acceptable at 75%. The test-retest reliability varied among the different domains. The reliability of questions regarding aesthetics, functions associated with CLP, and treatment satisfaction was good to excellent (intraclass correlation coefficient (ICC) = 0.51 to 0.89). Good to excellent (ICC = 0.61 to 1.0) reliability was also found for the quality of life in various life domains and the wellbeing scales. The reliability of the body image scale was moderate (kappa = 0.43-0.60) for most items and lower than that of other scales used in this study. The reliability of the mean depression symptom score (ICC = 0.93) and the mean non-specific physical symptoms score (ICC = 0.85) were excellent. The reliability of the mandibular function impairment was good (ICC = 0.67). The conclusion of the study is that an overall reliability was good for the multidimensional questionnaire. 相似文献
106.
107.
108.
Jawad H. Butt Nikolaj Ihlemann Ole De Backer Lars Søndergaard Eva Havers-Borgersen Gunnar H. Gislason Christian Torp-Pedersen Lars Køber Emil L. Fosbøl 《Journal of the American College of Cardiology》2019,73(13):1646-1655
Background
Patients undergoing surgical aortic valve replacement (SAVR) are considered at high risk of infective endocarditis (IE). However, data on the risk of IE following transcatheter aortic valve replacement (TAVR) are sparse and limited by the lack of long-term follow-up as well as a direct comparison with patients undergoing SAVR.Objectives
This study sought to investigate the long-term incidence of IE in patients undergoing TAVR and to compare the long-term risk of IE with patients undergoing isolated SAVR.Methods
In this nationwide observational cohort study, all patients undergoing TAVR and isolated SAVR from January 1, 2008, to December 31, 2016, with no history of IE and alive at discharge were identified using data from Danish nationwide registries.Results
A total of 2,632 patients undergoing TAVR and 3,777 patients undergoing isolated SAVR were identified. During a mean follow-up of 3.6 years, 115 patients (4.4%) with TAVR and 186 patients (4.9%) with SAVR were admitted with IE. The median time from procedure to IE hospitalization was 352 days (25th to 75th percentile: 133 to 778 days) in the TAVR group and 625 days (25th to 75th percentile: 209 to 1,385 days) in the SAVR group. The crude incidence rates of IE were 1.6 (95% confidence interval [CI]: 1.4 to 1.9) and 1.2 (95% CI: 1.0 to 1.4) events per 100 person-years in TAVR and SAVR patients, respectively. The cumulative 1-year risk of IE was 2.3% (95% CI: 1.8% to 2.9%) and 1.8% (95% CI: 1.4% to 2.3%) in TAVR and SAVR patients, respectively. Correspondingly, the cumulative 5-year risk of IE was 5.8% (95% CI: 4.7% to 7.0%) and 5.1% (95% CI: 4.4% to 6.0%), respectively. In multivariable Cox proportional hazard analysis, TAVR was not associated with a statistically significant different risk of IE compared with SAVR (hazard ratio: 1.12; 95% CI: 0.84 to 1.49).Conclusions
The 5-year incidence of IE following TAVR was 5.8% and not significantly different than the incidence following SAVR. 相似文献109.
Per Wiger Gunnar Blomqvist Jorma Styf 《Journal of plastic surgery and hand surgery》2013,47(4):315-320
Intramuscular pressure (IMP) was measured in 16 patients during secondary wound closure by dermatotraction with external tissue extension (ETE®). Secondary wound closure was done 4-16 days after fasciotomy for acute compartment syndrome. The traction between wound edges was 2.5 N in the first six patients and 3.5 N in the following 10 patients. Mean (SD) IMP was 6.9 (3.5) mmHg before wound closure. It increased to 12.3 (1.4) mmHg in the 2.5 N group and to 24.7 (7.0) mmHg in the 3.5 N group when dermatotraction was applied. Mean (SD) leg perfusion pressure in the 2.5 N group decreased by 7% to 69.3 (10.9) mmHg and in the 3.5 N group by 23% to 62.2 (7.4) mmHg. None of the patients needed a skin graft. We conclude that dermatotraction by ETE® raises IMP intraoperatively sufficiently to preserve adequate limb perfusion pressures. 相似文献