Movable core guide wire: evaluation of improved model

Six commercially available movable core guide wires were compared with each other and with a new design in glass models simulating tortuous vessels. The results demonstrate a wide variability in performance of the commercially available wires and the superiority of the new design.     

Community level alcohol availability and enforcement of possession laws as predictors of youth drinking

BACKGROUND: Despite a minimum legal drinking age, many young people use alcohol. Environmental strategies to control youth drinking focus on restricting access and the enforcement of possession laws. This study examines the relationship between use of these strategies and the frequency of youth alcohol use and related problems. METHODS: Participants were 16,694 students, ages 16-17 in 92 communities in Oregon. A multi-level analysis of a repeated cross-sectional statewide student survey was conducted. The outcome measures examined include 30-day frequency of alcohol use, binge drinking, use of alcohol at school, and drinking and driving. RESULTS: The rate of illegal merchant sales in the communities directly related to all four alcohol-use outcomes. There was also evidence that communities with higher minor in possession law enforcement had lower rates of alcohol use and binge drinking. The use of various sources in a community expanded and contracted somewhat depending on levels of access and enforcement. CONCLUSIONS: This evidence provides empirical support for the potential utility of local efforts to maintain or increase alcohol access control and possession enforcement.     

Peripartale psychiatrische Erkrankung—Unterstützung durch Männer?

We investigated the partners of 27 women with pre- or postpartal psychiatric disorders. All women were treated as inpatients at a mother-child unit after delivery.The men's behaviour as partners and fathers was rated in a categorical-qualitative way. We found that nearly one third of the men can be described as "supportive". This finding strongly correlates with the subjective experience of the corresponding wives. In the subgroup of women already suffering from prepartal psychiatric disorders before delivery, the majority of the men were rated and experienced as "non-supportive". Using the standardised Operationalised Psychodynamic Diagnostic questionnaire (OPD),we describe the personality structure of,support-ing" men and some resulting therapeutic consequences in "non-supporting" cases. In addition,we found a remarkable reduction in the length of hospital stay in the families with supporting men.     

Which types of aggressive behaviour are associated with suicidal and self-injurious behaviour at the time of admission?

BACKGROUND: In psychiatry and psychotherapy, dealing with aggressiveness and autoaggressiveness is of great importance. Our aim was to find a link between overt aggressive and autoaggressive behaviour, which could be readily observed. SAMPLING AND METHODS: We investigated the frequency, type and intensity of aggressive, suicidal and self-injurious behaviour exhibited by 521 successively admitted psychiatric patients at the time of admission with the help of a standardised instrument (Social Dysfunction and Aggression Scale). The Social Dysfunction and Aggression Scale enables the investigation of 9 different types of overt aggressive behaviour and 2 different types of autoaggressive behaviour (suicidal vs. self-injurious behaviour). After calculating correlations between single variables, we attempted to estimate the predictive value of the different types of aggressive behaviour for suicidal and self-injurious behaviour by using ordinal regression models. In addition, the categorical information of our data was evaluated by loglinear analyses. RESULTS: Our study showed that all degrees of aggressiveness (low, moderate, high), which are exhibited in different types of aggressive behaviour, were linked to an increased risk of self-injurious behaviour. No correlation was found, however, between overt aggressive behaviour and suicidal behaviour. Only in the subgroup of depressive disorders did we establish that the risk of aggressive behaviour was decreased and the risk of suicidal behaviour was increased at the time of admission. CONCLUSIONS: The strong relationship between aggressive behaviour and self-injurious behaviour has previously been described in specific diagnostic subgroups, but not yet in a heterogeneous population of psychiatric in-patients from a defined catchment area. We, therefore, conclude that the link between aggressive and self-injurious behaviour could be a general one. Exhibiting aggressive behaviour and self-injurious behaviour within a short time span may be the result of an increased or disinhibited aggressive potential, which is independent of a specific diagnosis. As such, it possibly represents the general consequence of a highly altered state of mind and does not seem to be linked to a specific diagnostic subgroup. In psychiatric emergency situations, the previously described close relationship between aggressive and self-injurious behaviour should be taken into account.     

Ethnic minorities and aggressive behaviour in psychiatric in-patients: an investigation using a "Matched-Pair" design

In a group of 105 mentally ill immigrants we investigated the intensity and the frequency of aggressive behaviour at the time of admission with the help of two standardized instruments: the "Social Dysfunction and Aggression Scale" (SDAS) and the "Modified Overt Aggression Scale" (MOAS). As many as possible collateral informants were contacted to gather all information available for the aggressiveness rating. The immigrant group was compared to a matched group of German patients. 416 German patients had to be investigated until 105 of them fulfilled the matching criteria. The matching variables were: age, gender, diagnosis (ICD-10), severity of mental illness (CGI) and social status. The physicians who carried out the matching process and who carried out the aggression-rating were "blind" to the aim of the investigation. We found out that there was no significant difference between immigrants and German patients when the sum-scores of the SDAS and the MOAS are compared (N = 210). When SDAS single variables were compared German patients had a higher severity and frequency of "physical violence towards other persons". We interpreted this finding as an increased level of disinhibition which may be correlated to a higher acceptance of aggressive behaviour in German culture compared to normative beliefs of Mediterranean immigrants.     

Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease

PURPOSE: Hepatic venous occlusive disease is a severe side effect after administration of busulfan before hematopoietic stem cell transplantation. The syndrome is characterized by liver enlargement, fluid retention, jaundice, and weight gain. Endothelial injury has been described as the precipitating factor. The link between busulfan administration and endothelial damage has not been established thus far. METHODS: Complementary deoxyribonucleic acid expression arrays were used to screen for busulfan responsive genes in ECV304 cells. Specific messenger ribonucleic acid and protein levels were examined by real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Serum samples of 15 pediatric patients with leukemia were analyzed for busulfan and cytokine levels. RESULTS: We identified a member of the transforming growth factor beta superfamily, activin A, to be induced in the human cell line ECV304 after exposure to busulfan in a time- and concentration-dependent manner. Maximum effects were observed at 120 and 168 hours for activin A messenger ribonucleic acid and protein, respectively. Preincubation with the protein kinase C inhibitor bisindolylmaleimide I (10 nmol/L) abolished activin A induction by busulfan (P <.05). Activin receptors were detected in ECV304. Both tissue factor and cyclooxygenase 2 were significantly induced by busulfan (P <.05). In a parallel in vivo study a significant increase in serum activin A concentration was found 4.5 hours after the second dose of busulfan. CONCLUSION: The data demonstrate that busulfan induces activin A both in vitro and in vivo. In view of the multiple targets of activin A (inflammation, proliferation, apoptosis, and coagulation), these findings may be of relevance to our understanding of venous occlusive disease.     

Axillary dissection is not required for all patients with breast cancer and positive sentinel nodes

HYPOTHESIS: Sentinel node (SN) biopsy for breast cancer enhances staging sensitivity, often demonstrating only micrometastases (<2 mm) or isolated, keratin-positive cells. When SN metastasis is present, the value of additional axillary dissection is unclear and not all patients benefit from axillary lymph node dissection (ALND). DESIGN: Prospective cohort study, median 32-month follow-up. SETTING: Multidisciplinary breast cancer centers. PATIENTS: Forty-six women having SN metastases diagnosed between May 1, 1996, and September 1, 2001, who refused ALND or were recommended to omit ALND owing to serious comorbid conditions. INTERVENTIONS: Isosulfan blue dye-directed SN biopsy. Axillary lymph node dissection was not performed. Standard breast irradiation was given. Adjuvant systemic therapy was provided as determined by an oncologist. Interval clinical evaluation was performed. MAIN OUTCOME MEASURE: Axillary and systemic failure rates. RESULTS: Mean patient age was 61.6 years (age range, 36-92 years). Mean tumor size was 1.65 cm (range, 0.4-5.5 cm). Thirty-five (76%) of 46 tumors were ductal carcinomas and 39 (87%) of 45 were estrogen receptor-positive. A mean of 2.6 SNs were identified (median, 2; range, 1-7). Thirty-nine patients (85%) had a single positive SN; the remaining 7 patients (15%) had 2 positive SNs. Seven patients (15%) had macrometastases (>2 mm); 16 (35%) had micrometastases (<2 mm); and 23 (50%) had cellular metastases. Only 16 positive SNs (35%) were seen on hematoxylin-eosin staining, while 30 SNs (65%) had positive immunohistochemical staining. There have been no axillary recurrences. One patient (2%) developed distant metastases during follow-up (range, 4-61 months). CONCLUSIONS: Patients with SN metastases who did not have ALND had a low incidence of regional failure. To confirm this observation, we suggest that patients with SN metastases are ideal candidates for trials evaluating the necessity of ALND.