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991.
Gregory A. Fonzo Taru M. Flagan Sarah Sullivan Carolyn B. Allard Erin M. Grimes Alan N. Simmons Martin P. Paulus Murray B. Stein 《Psychiatry Research: Neuroimaging》2013,211(2):93-103
Childhood maltreatment (CM) is a strong risk factor for development of posttraumatic stress disorder (PTSD) upon adult exposure to extreme adverse events. However, the neural underpinnings of this relationship are not well understood. Here, we test the hypothesis that severity of CM history is positively correlated with emotion-processing limbic and prefrontal brain activation/connectivity and negatively correlated with prefrontal gray matter volumes in women with PTSD due to intimate-partner violence (IPV-PTSD). Thirty-three women with IPV-PTSD underwent structural and functional magnetic resonance imaging while completing a facial emotion processing task. Multivariate regressions examined the relationship of CM to patterns of activation, connectivity, and gray matter volumes. CM severity was: (a) positively correlated with ventral ACC activation while processing angry faces; (b) negatively correlated with dorsal ACC and insula activation while processing fear and angry faces, arising from positive correlations with the shape-matching baseline; (c) positively correlated with limbic–prefrontal connectivity while processing fear faces but negatively correlated with amygdalo–insular connectivity while processing fear and angry; and (d) negatively correlated with prefrontal gray matter volumes. These results suggest CM exposure may account for variability in limbic/prefrontal brain function and prefrontal structure in adulthood PTSD and offer one potential mechanism through which CM confers risk to future development of PTSD. 相似文献
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Dr. Gregory G. Kolden Marjorie H. Klein Timothy J. Strauman Sarah Chisholm-Stockard Erin Heerey Kristin L. Schneider 《Psychotherapy research》2013,23(3):165-177
Abstract In a prior study (Kolden & Klein, 1996), the authors found that the relationships between global personality pathology and early psychotherapy change processes (as defined by the Generic Model of Psychotherapy) were moderated by the extent of the patient's acute symptomatic and interpersonal distress. In the current study, the authors reanalyzed the same data to examine similarities and differences between personality disorder Clusters B (dramatic, emotional, or erratic) and C (anxious or fearful) in therapy process. In general, we found that more distressed patients reported greater defensiveness. There were no significant interactions between symptomatic distress and personality pathology in the prediction of any of the process variables. However, interpersonal distress moderated relationships between Clusters B and C and some therapy processes. Patients high in Cluster B felt more open and involved in the session when they were less distressed by their interpersonal problems at the start of therapy. In contrast, openness and insight were impeded among patients high in Cluster C when they were less distressed interpersonally. Therapists generally used more direct interventions and exploration of past experiences when working with patients higher in Cluster C pathology. However, therapists used direct interventions more specifically when patients with more severe Cluster B pathology were also higher in interpersonal distress. The discussion considers implications for the facilitation of productive early therapy process in patients suffering from Cluster B or C personality pathology. 相似文献
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Daniele Pastori Evaristo Ettorre Gregory Y.H. Lip Angela Sciacqua Francesco Perticone Francesco Melillo Cosmo Godino Rossella Marcucci Martina Berteotti Francesco Violi Pasquale Pignatelli Mirella Saliola Danilo Menichelli Marco Antonio Casciaro Vito Menafra 《British journal of clinical pharmacology》2020,86(12):2455
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