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31.
32.
Maximal static expiratory and inspiratory mouth pressures (PEmax and PImax) and quadriceps femoris muscle strength were measured in 25 patients aged 16-28 years with cystic fibrosis (mean FEV1 46% predicted). Mean (SD) PEmax was 64% (18%) predicted (below 75% predicted in 16 of the 25 patients), and PImax was 64% (24%) predicted (below 75% predicted in 14 patients). Quadriceps muscle strength was 68% (20%) predicted (below 75% predicted in 17 patients). The relatively small reduction in respiratory muscle strength in these patients was unlikely to have contributed appreciably to their respiratory problems. 相似文献
33.
Bilateral ischemic optic neuropathy and retinal vascular occlusions associated with lymphoma and sepsis. Clinicopathologic correlation 总被引:1,自引:0,他引:1
The authors report the clinicopathologic correlation of a patient with non-Hodgkin's mixed-cell lymphoma who had impairment of the circulation of the optic nerve and retina in both eyes. The results of histopathologic examination showed that the pial septa of the optic nerves were infiltrated by lymphoma and that there was extensive infarction of the orbital portions of both optic nerves and occlusion of both central retinal arteries and the right central retinal vein by thrombi with bacteria. The infiltration of the optic nerves seemed to be resistant to therapy. 相似文献
34.
Environmental and genetic determinants of the hypercoagulable state and cardiovascular disease in renal transplant recipients 总被引:4,自引:1,他引:3
Background. Fibrinogen and factor VII coagulant
activity (VIIc), risk factors for cardiovascular disease (CVD) in the
general population, could contribute to CVD risk in renal transplant
recipients (RTR). Methods. We measured fibrinogen and
VIIc in 38 RTR and 31 controls, along with prothrombin fragment F1+2 and
D-Dimer (markers of coagulation and fibrinolytic activation), plasma lipids
and the acute phase response cytokine, interleukin 6. The effect of genetic
polymorphisms of {beta}-fibrinogen (G/A-455) and
factor VII (Arg/Gln353) was explored. Results. F1+2,
D-Dimer, and fibrinogen were increased in all RTR, indicating a chronic
prothrombotic state. Fibrinogen correlated with age, F1+2, and trough
cyclosporin A (CsA). RTR carriers of the A-455
allele had a greater increment in plasma fibrinogen concentration and
correlation with CsA than homozygotes for the G-455
allele. Interleukin 6 was increased in RTR confirming that a persistent
low-grade acute-phase response could contribute to increased fibrinogen.
Differences in plasma VIIc were associated with factor VII genotype,
disease status, and blood lipids. Carriers of the Gln353 allele had 30
lower VIIc when compared with Arg353 homozygotes, which could confer a
reduced thrombotic risk. The 12 RTR with CVD or metabolic complications
(RTR+) were more hyperlipidaemic and had higher fibrinogen and VIIc than
the 26 RTR free of disease complications (RTR-), or the controls.
Conclusions. Long-term RTR manifest features of a
chronic prothrombotic and persistent inflammatory state. Alterations in
fibrinogen and VIIc in RTR arise in part as a result of interactions
between common genetic and environmental factors, and these changes could
contribute to the increased risk of CVD in RTR. 相似文献
35.
Tim Elliott Marc Bonneville Juan Carlos Zúiga-Pflücker Paul R. Walker David Essayan Nicolas Glaichenhaus Anna Vyakarnam Jean-Laurent Casanova Yang Liu Hugh Auchincloss Jr Gerry Waneck Christian LeGuern Cezmi Akdis Allison Green 《Current opinion in immunology》2002,14(6):673
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in immunology. 相似文献
36.
37.
We have investigated contamination of extradural catheters during normal
handling with starch powdered gloves. In the laboratory, extradural
catheters were handled in sterile fields with both powdered and
non-powdered gloves, simulating preparation for patient insertion. The
catheters together with glove samples were then examined using a Zeiss 940
scanning electron microscope. Microscopy of samples revealed starch
contamination of the catheters handled with powdered gloves, especially in
the side hole areas. We conclude that extradural catheters may be
contaminated easily by starch powder from surgical gloves. This powder may
then be deposited into the extradural space. The effect of starch in the
extradural space is not known but starch is known to cause inflammatory and
granulomatous reactions in other parts of the body as well as being
directly allergenic. Powder contamination of catheters may be avoided
easily by the use of powder-free gloves and we feel that these should be
used whenever possible.
相似文献
38.
Fatal haemopericardium in a 27 year old pregnant woman was caused by rupture of a dissecting aneurysm of the pulmonary artery. She had an uncorrected patent ductus arteriosus and severe pulmonary hypertension. The wall of the pulmonary artery showed atherosclerosis and cystic medionecrosis. 相似文献
39.
E C Green 《Social science & medicine (1982)》1992,35(2):121-130
Compared with both industrialized countries and other less developed parts of the world, most of sub-Saharan Africa suffers inordinately from sexually transmitted diseases (STDs). It has high prevalence rates of traditional STDs, such as gonorrhea and syphilis, and if accurate seroprevalence surveys were to be done, it would probably prove to have the highest HIV seropositive incidence in the world. Unlike the pattern in the West, AIDS is primarily a heterosexually transmitted disease in Africa. This appears to be largely because of the prevalence of other untreated or improperly treated STDs. Therefore to lower the incidence of STDs would be to curtail the spread of HIV infection. The problem becomes how exactly to accomplish this. Most STD cases are never even presented at biomedical health facilities; they are presented to traditional healers. Both healers and their patients seem to believe that traditional STD cures are more effective than 'modern' cures, although the former are probably biomedically ineffective. While there is scant ethnomedical literature on STDs in Africa, the present paper presents Swaziland findings and related evidence from other African societies that the ultimate cause of several common STDs is believed to be the violation of norms governing sexual behavior, requiring traditional rather than biomedical treatment. Traditional healers therefore need to be a central part of any scheme to lower the incidence of STDs. 相似文献
40.
Introduction: apoptosis in the immune system. 总被引:5,自引:0,他引:5