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491.
492.
兴奋性氨基酸类神经毒剂与粉防己碱(Tet)共同作用于原代培养胎鼠大脑皮层神经元24h,发现10-7,10-6mol·L-1Tet明显降低谷氨酸(Glu),β-N-oxalylamino-L-alanine(BOAA)和β-N-methylamino-L-alanine(BMAA)导致的培养液乳酸脱氢酶(LDH)活性增高,细胞形态损害减轻,细胞数量增加。对NMDAA介导的神经元损伤改变无影响。提示Tet对某些Glu类神经毒剂引起的胎鼠大脑皮层神经元损伤有一定保护作用,其机制可能是抑制细胞膜Na+通道开放,阻止膜去极化而影响电压依赖性Ca2+通道启动。对NMDA受体可能亦有一定作用。 相似文献
493.
CT biopsy of abdominal tumors: aids for lesion localization 总被引:1,自引:0,他引:1
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KM Main JT Jorgensen NT Hertel S Jensen L Jakobsen 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(3):331-334
Non-compliance in children receiving growth hormone (GH) treatment is often caused by pain on injection and difficulties in administration of GH. It has been suggested that automatic needle insertion diminishes pain perception. We quantitatively measured pain intensity on injection with two prototype pens for GH administration, providing either manual or automatic sc needle insertion, using a combined visual analogue/facial scale and a five-item scale in 18 children. With the automatic pen there was a significantly lower maximum pain score compared with the manual pen (median 28.5 versus 52.0mm) as well as a lower mean pain score (mean 13.7 versus 23.5 mm). The five-item scale revealed that automatic needle insertion was significantly less painful than manual insertion and 13 patients chose to continue treatment with the automatic pen. In conclusion, pain during GH injection can be significantly diminished by automatic needle insertion, which may improve compliance in long-term GH treatment. 相似文献
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Miller DL; Doppman JL; Chang R; Simmons JT; O'Leary TJ; Norton JA; Spiegel AM; Marx SJ; Aurbach GD 《Radiology》1987,165(3):601-607
Angiographic ablation of parathyroid adenomas with ionic contrast material was performed in 24 patients with persistent hyperparathyroidism who had undergone at least one prior unsuccessful surgical resection; 23 had mediastinal adenomas. The success rate was 83% at 1 month after ablation and 71% at both 5 and 9 years. Ablation was successful in 85% of the patients in whom the catheter could be wedged into the artery feeding the adenoma. Long-term success was achieved in 89% of the patients in whom contrast enhancement persisted in the adenoma on computed tomographic scans obtained 24 hours later. Acute complications were seen only in patients with glands supplied by the inferior or superior thyroid arteries. Long-term complications were limited to permanent hypocalcemia, present in 8% of patients. Even if unsuccessful for ablation, the procedure may provide localization and does not preclude surgical resection. It is recommended for most patients with persistent hyperparathyroidism and mediastinal adenomas, especially adenomas supplied by the internal thoracic artery. 相似文献
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499.
Drainage of pelvic abscesses through the greater sciatic foramen 总被引:4,自引:0,他引:4
Butch RJ; Mueller PR; Ferrucci JT Jr; Wittenberg J; Simeone JF; White EM; Brown AS 《Radiology》1986,158(2):487-491
A computed tomographic (CT) guided transgluteal approach through the greater sciatic foramen was used to drain pelvic abscesses and fluid collections in 21 patients. Ideal catheter placement should traverse the lower portion of the greater sciatic foramen at the level of the sacrospinous ligament. This avoids the vascular and neural elements that are located slightly cephalad at the level of the piriformis muscle. Percutaneous drainage through this approach was successful in avoiding surgery in 17 patients (81%). Pain was the most common complication and was generally associated with a more cephalad approach, transgressing the piriformis and the sacral plexus. CT-guided percutaneous drainage of pelvic abscesses through the greater sciatic foramen should be used when the more standard transperitoneal approach is not possible. 相似文献
500.