全文获取类型
收费全文 | 474篇 |
免费 | 17篇 |
国内免费 | 22篇 |
专业分类
儿科学 | 27篇 |
基础医学 | 43篇 |
口腔科学 | 9篇 |
临床医学 | 52篇 |
内科学 | 73篇 |
皮肤病学 | 3篇 |
神经病学 | 1篇 |
特种医学 | 184篇 |
外科学 | 24篇 |
综合类 | 2篇 |
预防医学 | 14篇 |
眼科学 | 7篇 |
药学 | 44篇 |
肿瘤学 | 30篇 |
出版年
2023年 | 1篇 |
2021年 | 4篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 4篇 |
2017年 | 1篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 12篇 |
2012年 | 2篇 |
2011年 | 4篇 |
2010年 | 11篇 |
2009年 | 9篇 |
2008年 | 8篇 |
2007年 | 22篇 |
2006年 | 8篇 |
2005年 | 13篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 3篇 |
2001年 | 9篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 32篇 |
1997年 | 44篇 |
1996年 | 25篇 |
1995年 | 27篇 |
1994年 | 19篇 |
1993年 | 12篇 |
1992年 | 3篇 |
1991年 | 8篇 |
1990年 | 10篇 |
1989年 | 19篇 |
1988年 | 25篇 |
1987年 | 16篇 |
1986年 | 18篇 |
1985年 | 22篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 16篇 |
1981年 | 7篇 |
1980年 | 15篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 8篇 |
1976年 | 14篇 |
1975年 | 4篇 |
排序方式: 共有513条查询结果,搜索用时 31 毫秒
431.
年龄及人参皂甙 Rg1 对大鼠大脑皮层 NO 释放的影响 总被引:14,自引:0,他引:14
探讨了NO与衰老的关系及与Rg1抗衰老机制的关系。用Griess法,3H-L-精氨酸转化法分别研究大鼠大脑皮层细胞NO含量及NOS活性,观察其随龄变化及人参皂甙Rg1(Rg1)对老年鼠NO及NOS的影响。实验表明,成年鼠(9月龄)与青年鼠(3月龄)NO含量及NOS活性无显著性差异。老年鼠(27月龄)脑皮层NO含量明显高于青年鼠和成年鼠,NOS活性也明显增高。老年鼠给予Rg1后可显著减少大脑皮层NO含量和降低NOS活性。结果提示,NO与衰老关系密切,Rg1的抗衰老作用与其对NOS活性的抑制有关。 相似文献
432.
Gadow EC; Paz JE; Lopez-Camelo JS; Dutra MG; Queenan JT; Simpson JL; Jennings VH; Castilla EE 《Human reproduction (Oxford, England)》1998,13(7):1991-1995
Unintended pregnancies are accepted as associated with social, maternal and
perinatal risks, but few data exist in South America. In a selected network
of hospitals participating in the ECLAMC (Spanish acronym for Latin
American Collaborative Study of Congenital Malformations), the frequency of
unintended pregnancies was 49.8% in 5155 mothers of normal liveborns, as
interviewed in the post-partum period (1992-1994). Compared with the
intended pregnancy group, these mothers were more frequently multiparous,
conceived easily, had a surprisingly higher mean maternal age, lower
educational level, and Black ancestors. The frequency of mistimed
pregnancies was the highest among primiparae. No adverse perinatal outcome
could be found with regard to low birthweight (< 2500 g), prematurity
(< 37 weeks), and early neonatal death. The rates of Caesarean delivery,
twinning and sex ratio were similar in intended and unintended groups.
Logistic regression analysis showed that maternal education could be a
confounding factor associated with other maternal variables. The rate of
unintended pregnancies in the present study is significantly higher than
that described for other regions. Knowledge of the characteristics of women
experiencing unintended pregnancies would allow proper public health
strategies.
相似文献
433.
Mueller PR; Saini S; Simeone JF; Silverman SG; Morris E; Hahn PF; Forman BH; McLoud TC; Shepard JO; Ferrucci JT Jr 《Radiology》1988,169(1):1-4
Twenty-six pleural biopsies were performed on 23 patients over a 3-year period. Twenty-three biopsies were performed guided with ultrasound; one, with computed tomography; and two, with fluoroscopy. Indications for an image-guided pleural biopsy were (a) pleural masses or thickening that were either not seen on chest radiographs or seen only on one view and (b) small or loculated pleural effusions of unknown cause with no mass seen. If only pleural fluid was present, reverse bevel needles were used for biopsy (n = 15). If a discrete pleural mass or thickening was seen with cross-sectional imaging, standard (16-20 gauge) biopsy needles were used (n = 11). In the 23 patients, biopsy results were true positive in ten (nine with malignancy, one with tuberculous pleurisy), true negative in ten (confirmed either at subsequent thoracotomy or clinical follow-up), and false negative in three. Complications were few, with a significant pneumothorax occurring in two patients (8.7%). Image-guided biopsy of small pleural lesions and small pleural effusions can be performed by the radiologist who understands the special needles and techniques involved. 相似文献
434.
The outcome of ankylosing spondylitis: a study of 100 patients 总被引:18,自引:4,他引:14
The outcome was studied in 100 patients with adult-onset primary ankylosing
spondylitis (AS). After a mean disease duration of 16 yr, 51.5% of the
patients were employed in full-time work. Cessation of work occurred at a
mean disease duration of 15.6 yr, and was significantly associated with
female sex, low levels of education, acute anterior uveitis, 'bamboo spine'
and the co-existence of non- rheumatic diseases. Functional outcome was
studied by analysing activities of daily living, and revealed similar
findings in males and females. Most of the loss of function occurred during
the first 10 yr of disease, and correlated significantly with the
occurrence of peripheral arthritis, spinal X-ray changes of AS and
development of 'bamboo spine'. After > 20 yr of disease, > 80% of the
patients still complained of daily pain and stiffness, and > 60%
reported daily use of drugs.
相似文献
435.
Magnetic resonance (MR) imaging of the breast is currently of limited value because of lack of specificity. Enhanced MR imaging with gadolinium diethylenetriaminepentaacetic acid (DTPA) has been shown to be helpful in the further characterization of breast tissue. This prospective study attempted to differentiate benign and malignant breast disease with a dynamic enhancement technique. Bolus injection of Gd-DTPA and a short MR imaging time were used to examine 18 patients with a palpable breast mass. Construction of enhancement profiles helped effectively differentiate benign and malignant lesion (P less than .001). Dynamic MR imaging shows promise for the further characterization of breast tissue and, particularly, identification of breast carcinoma. 相似文献
436.
Sphincter preservation in patients with low rectal cancer treated with radiation therapy with or without local excision or fulguration 总被引:8,自引:0,他引:8
Twenty-six patients with small cancers limited to the lower two-thirds of the rectum were treated with conservative surgery and radiation therapy (XRT). The selection factors for this approach were age, refusal of a permanent colostomy, or the high risk of local recurrence because of inadequate surgical margin or palpable residual tumor after local surgical treatment alone. In patients treated with local excision or fulguration followed by XRT, there was a 6% local failure rate (one in 17); in 16 of 17 patients receiving radiation doses above 4,500 cGy, the local control was complete for follow-up periods of 6 months to 7 years. In nine patients treated with XRT for residual tumor, local failure occurred in five (56%). The disease-free survival for those without residual tumor versus those with residual tumor was 88% and 44%, with median follow-up periods of 20 and 23 months, respectively. Serious late complications occurred only if total doses were greater than 6,300 cGy. Local excision combined with XRT proved to be a safe alternative to radical surgery in selected patients and resulted in excellent local control while allowing preservation of anal sphincter function. 相似文献
437.
Loflin TG; Simeone JF; Mueller PR; Saini S; Stark DD; Butch RJ; Brady TJ; Ferrucci JT Jr 《Radiology》1985,157(2):457-459
Fifty-three samples of gallbladder bile were obtained at the time of cholecystectomy from patients with the clinical diagnosis of acute or chronic cholecystitis. Five bile samples from patients with clinically normal gallbladders also were obtained. Proton magnetic resonance (MR) relaxation times, protein content, and water content were determined for the bile samples, and the data were grouped according to pathologic diagnosis, which disclosed 11 cases of acute cholecystitis, 41 cases of chronic cholecystitis, and six normal gallbladders. There was no significant difference in the mean T1 and T2 values between the groups with acute and chronic cholecystitis. Patients with chronic cholecystitis were found to have more concentrated bile than those with acute cholecystitis. Protein content varied widely within both groups of patients. We conclude that T1 and T2 relaxation times do not reliably differentiate acute from chronic cholecystitis. 相似文献
438.
439.
440.