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991.
FACTORS ASSOCIATED WITH CIVIC ENGAGEMENT IN ADOLESCENCE: THE EFFECTS OF NEIGHBORHOOD,SCHOOL, FAMILY,AND PEER CONTEXTS 下载免费PDF全文
Giulia Rossi Michela Lenzi Jill D. Sharkey Alessio Vieno Massimo Santinello 《Journal of community psychology》2016,44(8):1040-1058
Research on youth civic engagement has emphasized the importance of growing up in a civic context. We examined the relative influence of neighborhood characteristics (neighborhood opportunities and intergenerational closure), civic education at school, friends’ civic engagement, and parents’ civic engagement on civic attitudes and civic behaviors among youths. Participants were 403 11‐ to 15‐year‐old adolescents randomly selected from the city register of a midsized city in Italy. The hierarchical regression analysis found that all analyzed contexts were related to adolescent civic engagement. In particular, intergenerational closure, friends’ civic engagement, and parents’ civic engagement were associated with both civic attitudes and civic behaviors. Findings highlighted the importance of considering multiple contexts to understand what factors are associated with youth civic engagement. We discuss ways that findings can be transmitted into further research and practice to address the multiple contexts in which youths are embedded and their relative influence on adolescent civic engagement. 相似文献
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Giuseppe Brescia Gino Marioni Sebastiano Franchella Giulia Ramacciotti Luciano Giacomelli Filippo Marino Alessandro Martini 《European archives of oto-rhino-laryngology》2016,273(3):655-660
Even after appropriate surgical therapy, a significant number of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) experience recurrences. The end-point of this prospective study was to apply univariate and multivariate statistical models to identify clinical, pathological, and laboratory variables that could predict CRSwNP recurrence after endoscopic sinus surgery. The study enrolled 143 patients between 2010 and 2013, who were all treated by the same surgeon for CRSwNP. Twenty-one patients developed recurrent polyposis. The recurrence rate was significantly higher for the eosinophilic than for the non-eosinophilic type (p = 0.020). Among the patients who developed a recurrence, the disease-free interval was significantly shorter for those with eosinophilic-type polyposis (p = 0.003). Univariate statistical analysis disclosed significant associations between CRSwNP recurrence and age (p = 0.035), allergy (p = 0.014), and eosinophilic granulomatosis with polyangiitis (p = 0.01). The multivariate model showed that only histological evidence of the eosinophilic type of CRSwNP retained an independent prognostic significance in relation to recurrent polyposis (p = 0.033). Judging from our results, it is reasonable to consider both stricter follow-up protocols and postoperative adjuvant medical treatments for patients with a histological diagnosis of eosinophilic-type CRSwNP. 相似文献
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Complex chromosomal rearrangements leading to MECOM overexpression are recurrent in myeloid malignancies with various 3q abnormalities 下载免费PDF全文
Carmen Baldazzi Simona Luatti Elisa Zuffa Cristina Papayannidis Emanuela Ottaviani Giulia Marzocchi Gaia Ameli Maria Antonella Bardi Laura Bonaldi Rossella Paolini Carmela Gurrieri Gian Matteo Rigolin Antonio Cuneo Giovanni Martinelli Michele Cavo Nicoletta Testoni 《Genes, chromosomes & cancer》2016,55(4):375-388
Chromosomal rearrangements involving 3q26 are recurrent findings in myeloid malignancies leading to MECOM overexpression, which has been associated with a very poor prognosis. Other 3q abnormalities have been reported and cryptic MECOM rearrangements have been identified in some cases. By fluorescence in situ hybridization (FISH) analysis, we investigated 97 acute myeloid leukemia/myelodysplastic syndrome patients with various 3q abnormalities to determine the role and the frequency of the involvement of MECOM. We identified MECOM rearrangements in 51 patients, most of them showed 3q26 involvement by chromosome banding analysis (CBA): inv(3)/t(3;3) (n = 26) and other balanced 3q26 translocations (t(3q26)) (n = 15); the remaining cases (n = 10) showed various 3q abnormalities: five with balanced translocations involving 3q21 or 3q25; two with homogenously staining region (hsr) on 3q; and three with other various 3q abnormalities. Complex rearrangements with multiple breakpoints on 3q, masking 3q26 involvement, were identified in cases with 3q21/3q25 translocations. Furthermore, multiple breaks were observed in two cases with t(3q26), suggesting that complex rearrangement may also occur in apparently simple t(3q26). Intrachromosomal gene amplification was another mechanism leading to MECOM overexpression in two cases with hsr on 3q. In the last three cases, FISH analysis revealed 3q26 involvement that was missed by CBA because of metaphases' suboptimal quality. All cases with MECOM rearrangements showed overexpression by real‐time quantitative PCR. Finally, MECOM rearrangements can occur in patients with 3q abnormalities even in the absence of specific 3q26 involvement, underlining that their frequency is underestimated. As MECOM rearrangement has been associated with very poor prognosis, its screening should be performed in patients with any 3q abnormalities. © 2016 Wiley Periodicals, Inc. 相似文献
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Giovanni Corona Giulia Rastrelli Antonio Silverii Matteo Monami Alessandra Sforza Gianni Forti Edoardo Mannucci Mario Maggi 《The journal of sexual medicine》2013,10(4):1114-1123
IntroductionThe Atherosclerosis Risk in Communities (ARIC) algorithm is one of the most efficient instruments for the prediction of incident type 2 diabetes. Recently, it has been shown to predict another relevant cardiovascular (CV) risk factor, such as chronic kidney disease.AimTo verify whether, in patients with erectile dysfunction (ED), the use of ARIC diabetes risk score might improve the efficacy in predicting major CV events of other CV risk algorithms specifically developed for the assessment of CV risk.MethodsA consecutive series of 2,437 men (mean age 52.5 ± 12.9 years) attending our outpatient clinic for sexual dysfunction was retrospectively studied. A subset of this sample (N = 1,687) was enrolled in a longitudinal study (mean follow‐up of 4.3 ± 2.6 years).Main Outcome MeasuresThe assessment of metabolic risk was evaluated with the ARIC algorithm. The assessment of CV risk was evaluated using the Progetto Cuore risk engine.ResultsIn the cross‐sectional study, ARIC score was inversely related with testosterone levels, sexual functioning, and penile blood flow. When longitudinal sample was analyzed, higher baseline ARIC score significantly predicted major adverse cardiovascular event (MACE) even when subjects with diabetes mellitus at baseline were excluded from the analysis (hazard ratio = 1.522 [1.086–2.135]; P = 0.015 for trend). In addition, among subjects classified as “low risk” (CV risk <20% at 10 years corresponding to <9% at 4.3 years) by Progetto Cuore, a receiving operating curve (ROC) analysis for ARIC (vs. MACE) allowed the identification of a threshold of 0.22, which had a positive predictive value for 4.3‐year MACE of 9%. Applying the ARIC score (with a threshold of 0.22) to Progetto Cuore “low‐risk” subjects, we could classify as “at high risk” 89.8% of subjects with incident MACE vs. 79.6% with Progetto Cuore only.ConclusionsIn patients with ED, identifying prediabetes, even with algorithms, predicts long‐term CV events. 相似文献
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Elsa Iannicelli Marco Di Pietropaolo Massimo Marignani Chiara Briani Giulia Francesca Federici Gianfranco Delle Fave Vincenzo David 《La Radiologia medica》2014,119(6):367-376
Purpose
The aim of our study was to evaluate the diagnostic accuracy of gadoxetic acid-enhanced magnetic resonance (MR) imaging both in the detection of hepatocellular carcinoma (HCC) and precancerous lesions and in the assessment of their evolution.Materials and methods
A retrospective study was undertaken on 56 patients with chronic liver disease and suspected liver lesions. We evaluated the number, size and signal intensity of the nodules on dynamic and hepatobiliary MR images. Follow-up studies were carried out every 3 months. Statistical analysis was performed using the Fisher’s exact test.Results
A total of 120 nodules were identified in 41 patients. Of these, 92/120 nodules (76.6 %; mean diameter 18.4 mm) showed the typical HCC vascular pattern: 90/92 nodules appeared hypointense and 2/92 were hyperintense on hepatobiliary phase images. An additional 28/120 hypointense, nonhypervascular nodules (23.3 %; mean diameter 11 mm) were detected on hepatobiliary phase images, 15 of which showed hypointensity also on the equilibrium phase images. During the 3- to 12-month follow-up, 14/28 nodules (mean diameter 13.3 mm) developed the typical vascular pattern of HCC.Conclusions
Gadoxetic acid-enhanced MR imaging is useful for detecting HCC as well as hypovascular nodules with potential progression to HCC. Lesions measuring more than 10 mm in diameter are at higher risk of developing into HCC (p = 0.0128). 相似文献1000.
Mario Mascalchi Giulia Picozzi Massimo Falchini Alessandra Vella Stefano Diciotti Laura Carrozzi Andrea Lopes Pegna Fabio Falaschi 《European journal of radiology》2014