全文获取类型
收费全文 | 2147篇 |
免费 | 190篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 113篇 |
妇产科学 | 65篇 |
基础医学 | 346篇 |
口腔科学 | 32篇 |
临床医学 | 183篇 |
内科学 | 366篇 |
皮肤病学 | 34篇 |
神经病学 | 339篇 |
特种医学 | 79篇 |
外国民族医学 | 1篇 |
外科学 | 235篇 |
综合类 | 73篇 |
一般理论 | 1篇 |
预防医学 | 119篇 |
眼科学 | 71篇 |
药学 | 143篇 |
中国医学 | 3篇 |
肿瘤学 | 118篇 |
出版年
2023年 | 15篇 |
2022年 | 17篇 |
2021年 | 45篇 |
2020年 | 24篇 |
2019年 | 38篇 |
2018年 | 59篇 |
2017年 | 27篇 |
2016年 | 39篇 |
2015年 | 42篇 |
2014年 | 49篇 |
2013年 | 81篇 |
2012年 | 127篇 |
2011年 | 131篇 |
2010年 | 59篇 |
2009年 | 67篇 |
2008年 | 102篇 |
2007年 | 79篇 |
2006年 | 90篇 |
2005年 | 121篇 |
2004年 | 80篇 |
2003年 | 81篇 |
2002年 | 72篇 |
2001年 | 74篇 |
2000年 | 61篇 |
1999年 | 69篇 |
1998年 | 33篇 |
1997年 | 30篇 |
1996年 | 30篇 |
1995年 | 20篇 |
1994年 | 15篇 |
1993年 | 18篇 |
1992年 | 52篇 |
1991年 | 45篇 |
1990年 | 48篇 |
1989年 | 44篇 |
1988年 | 44篇 |
1987年 | 26篇 |
1986年 | 38篇 |
1985年 | 28篇 |
1984年 | 30篇 |
1983年 | 24篇 |
1982年 | 21篇 |
1981年 | 13篇 |
1979年 | 15篇 |
1978年 | 9篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1975年 | 10篇 |
1972年 | 12篇 |
1970年 | 9篇 |
排序方式: 共有2339条查询结果,搜索用时 15 毫秒
51.
Marie Gauthier Melanie Vincent Sylvain Morneau Isabelle Chevalier 《European journal of pediatrics》2012,171(12):1839-1844
Acute bronchiolitis has been associated with an increasing hospitalization rate over the past decades. The aim of this paper was to estimate the impact of home oxygen therapy (HOT) on hospital stay for infants with acute bronchiolitis. A retrospective cohort study was done including all children aged ??12?months discharged from a pediatric tertiary-care center with a diagnosis of bronchiolitis, between November 2007 and March 2008. Oxygen was administered according to a standardized protocol. We assumed children with the following criteria could have been sent home with O2, instead of being kept in hospital: age ??2?months, distance between home and hospital <50?km, in-hospital observation ??24?h, O2 requirement ??1.0?L/min, stable clinical condition, no enteral tube feeding, and intravenous fluids <50?mL/kg/day. Children with significant underlying disease were excluded. A total of 177 children were included. Median age was 2.0?months (range 0?C11), and median length of stay was 3.0?days (range 0?C18). Forty-eight percent of patients (85/177) received oxygen during their hospital stay. Criteria for discharge with HOT were met in 7.1?% of patients, a mean of 1.8?days (SD 1.8) prior to real discharge. The number of patient-days of hospitalization which would have been saved had HOT been available was 21, representing 3.0?% of total patient-days of hospitalization for bronchiolitis over the study period (21/701). Conclusions: In this study setting, few children were eligible for an early discharge with HOT. Home oxygen therapy would not significantly decrease the overall burden of hospitalization for bronchiolitis. 相似文献
52.
53.
54.
Marie Robin Kavita Raj Sylvie Chevret Jordan Gauthier Hugues de Lavallade David Michonneau Donal McLornan Régis Peffault de Latour Victoria Potter Austin Kulasekararaj Flore Sicre de Fontbrune Antonio Pagliuca Ibrahim Yakoub‐Agha Gérard Socié Ghulam J. Mufti 《European journal of haematology》2018,101(4):466-474
55.
Christiane Charriaut‐Marlangue PhD Philippe Bonnin PhD MD Hoa Pham PhD Gauthier Loron MD Pierre‐Louis Leger MD Pierre Gressens PhD MD Sylvain Renolleau PhD MD Olivier Baud PhD MD 《Annals of neurology》2013,73(4):442-448
Nitric oxide (NO) is a powerful vasodilator, involved in both physiological functions and pathophysiological alterations of various regulatory processes, for example, the maintenance of vascular tone and inflammation. The recently demonstrated impact of exogenous NO on the central nervous system extends its role under normal and pathological conditions. At times neuroprotective, at times neurotoxic, NO is capable of different effects depending upon the extent of cerebral damage, the cellular redox state, and the spatiotemporal coordinates and concentration at which it is synthesized. This review provides new insights into the short‐ and long‐term effects of endogenous and exogenous NO in brain injury. ANN NEUROL 2013;73:442–448 相似文献
56.
Cecile Rousseau Françoise Armand Audrey Laurin‐Lamothe Marie‐France Gauthier Rita Saboundjian 《Child and Adolescent Mental Health》2012,17(3):187-190
Background: To help immigrant and refugee adolescents experiencing a severe academic delay cope with adversity, a school‐based intervention combining drama workshops and language awareness activities was piloted in two classrooms. Method: A qualitative analysis of participant observations was performed and the Strength and Difficulty Questionnaire and its Impairment Supplement was administered before and after the intervention. The observations were carried out in two Montreal high schools serving an underprivileged neighbourhood of immigrants, involving two classrooms of underschooled adolescents (n = 27) and two classes of similarly underschooled adolescents chosen among other teachers interested in the intervention, who accepted to participate as a comparison group (n = 28). Results: The adolescents shared their experiences of adversity and felt empowered by the workshops. Self‐reported impairment decreased in the intervention groups. Conclusion: The protective effect of creative language activities for immigrant and refugee youth should be further investigated. 相似文献
57.
PURPOSE OF REVIEW: Hospitalization and mortality rates associated with heart failure are persistently high. This is due partly to aging of the population but mostly to delayed progress in the pharmacological treatment of decompensated heart failure. We will review the current recommendations and most recent advancement in the pharmacological treatment of acute decompensated heart failure while providing a systematic approach to the management of this prevalent condition. RECENT FINDINGS: Loop diuretics, nitrates and inotropes such as dobutamine and milrinone are the current mainstay of acute heart failure management although their associated morbidity and possible mortality have raised serious concerns. Recent vasoactive agents such as Nesiritide, Tolvaptan and more recently the inotropic agent Levosimedan could offer improved hemodynamics and congestive relief to patients in acute pulmonary edema. SUMMARY: Despite the promising results of these agents, further clinical trials are required prior to their international approval as first-line therapy. Although we can be optimistic that these vasoactive drugs might have favorable clinical outcomes and improve the intricate management of decompensated heart failure, their associated mortality benefit remains unclear and controversial. 相似文献
58.
Liver regeneration and the effect of exogenous putrescine on regenerative activity after partial hepatectomy in cirrhotic rats. 总被引:3,自引:0,他引:3
There are conflicting data regarding the ability of the liver to regenerate after partial hepatectomy in animals and humans with cirrhosis. The purpose of this study was to document liver regeneration after partial hepatectomy in a carbon tetrachloride rat model of cirrhosis and to determine whether exogenous putrescine, a polyamine that has been reported to stimulate liver regeneration in animal models of acute liver failure, enhances regenerative activity in cirrhosis. Liver fibrosis and cirrhosis were produced by weekly intragastric gavage with carbon tetrachloride in 130 adult male rats. Vehicle-gavaged rats (n = 12) served as healthy controls. At surgery and at 4 and 8 hr after 70% hepatectomy, rats received normal saline solution or 1 or 10 mg/kg putrescine by intraperitoneal injection. Another group (n = 32) of carbon tetrachloride-treated rats was given putrescine (100 mg/kg) or normal saline solution twice daily for 10 days before partial hepatectomy and at 0, 4 and 8 hr after partial hepatectomy. Liver regeneration was documented 24 and 48 hr after partial hepatectomy on the basis of restitution of liver mass, ornithine decarboxylase activity and [3H]thymidine incorporation into liver DNA. Automated image analysis of the resected liver specimens separated carbon tetrachloride-treated rats into two subgroups: those with bridging fibrosis (fibrotic group) and those with micronodular cirrhosis (cirrhotic group). Restitution of liver mass and ornithine decarboxylase activity at 24 and 48 hr after partial hepatectomy were similar to carbon tetrachloride-treated rats (both fibrotic and cirrhotic) and vehicle-treated healthy controls.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
59.
60.