全文获取类型
收费全文 | 4395篇 |
免费 | 266篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 81篇 |
儿科学 | 242篇 |
妇产科学 | 84篇 |
基础医学 | 407篇 |
口腔科学 | 79篇 |
临床医学 | 318篇 |
内科学 | 1036篇 |
皮肤病学 | 122篇 |
神经病学 | 288篇 |
特种医学 | 73篇 |
外科学 | 766篇 |
综合类 | 126篇 |
一般理论 | 4篇 |
预防医学 | 199篇 |
眼科学 | 167篇 |
药学 | 272篇 |
中国医学 | 17篇 |
肿瘤学 | 389篇 |
出版年
2023年 | 31篇 |
2022年 | 62篇 |
2021年 | 175篇 |
2020年 | 84篇 |
2019年 | 114篇 |
2018年 | 133篇 |
2017年 | 85篇 |
2016年 | 119篇 |
2015年 | 153篇 |
2014年 | 163篇 |
2013年 | 238篇 |
2012年 | 324篇 |
2011年 | 346篇 |
2010年 | 192篇 |
2009年 | 129篇 |
2008年 | 210篇 |
2007年 | 254篇 |
2006年 | 222篇 |
2005年 | 185篇 |
2004年 | 156篇 |
2003年 | 151篇 |
2002年 | 153篇 |
2001年 | 77篇 |
2000年 | 60篇 |
1999年 | 68篇 |
1998年 | 36篇 |
1997年 | 21篇 |
1996年 | 19篇 |
1995年 | 23篇 |
1993年 | 12篇 |
1992年 | 63篇 |
1991年 | 51篇 |
1990年 | 63篇 |
1989年 | 48篇 |
1988年 | 36篇 |
1987年 | 37篇 |
1986年 | 27篇 |
1985年 | 25篇 |
1984年 | 29篇 |
1983年 | 22篇 |
1979年 | 24篇 |
1976年 | 17篇 |
1974年 | 21篇 |
1973年 | 20篇 |
1972年 | 18篇 |
1971年 | 12篇 |
1970年 | 18篇 |
1969年 | 24篇 |
1968年 | 27篇 |
1966年 | 15篇 |
排序方式: 共有4670条查询结果,搜索用时 62 毫秒
21.
22.
A. Sethi I. Singh A. K. Agarwal D. Sareen 《Indian journal of otolaryngology and head and neck surgery》2005,57(4):283-286
The prognostic significance of the size of mastoid air cell system in the results of myringoplasty has been a matter of debate. Fifty ears with dry central perforation following C.S.O.M. were investigated. The size of mastoid air cell system was determined with planimetry of the X-ray picture and eustachian tube function was assessed using flourescein dye and nasal endoscopy. Myringoplasty was performed in all the 50 ears and postoperative results in terms of graft take up and hearing gain were assessed. The correlation between the size of mastoid air cell system, results of myringoplasty and tubal function has been discussed. The results show no correlation between the size of mastoid air cell system, postoperative results of myringoplasty and eustachian tube function. 相似文献
23.
24.
A. Gautam S.A. Fischer A.F. Yango R.Y. Gohh P.E. Morrissey A.P. Monaco 《International immunopharmacology》2006,6(13-14):2023
Cell mediated immunity (CMI) was assessed by the ImmuKnow assay in 12 patients after kidney transplantation, who presented with viral infection. Treatment included lowering of immunosuppression in all cases and antiviral treatment if indicated. The assay was repeated during the follow up. The ImmuKnow assay at time of presentation of viral infections was 56.8 ± 58.2 (range 3–178; median 22) ATP ng/ml. With the clearance of viral infection and lowering of immunosuppression, the assay showed an increase in the level of CMI at 194.5 ± 118.9 (range 53–409; median 150) ATP ng/ml. There was viral clearance or stabilization in all cases and there was no incidence of allograft rejection. The ImmuKnow assay of CMI can be used to titrate initial immunosuppression reduction and its subsequent increase, in patients with viral infection after transplantation. 相似文献
25.
Ashwani Sethi Sumit Mrig Deepika Sethi A K Mandal A K Agarwal 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2006,102(1):82-84
We report the case of an 8-year-old boy with a parotid mass diagnosed to be a leiomyosarcoma. Considering the unresectable extent of the mass, the patient was subjected to radiotherapy. The patient developed distant metastasis following the course of radiotherapy and was put on chemotherapy. The child was lost to further follow up. To our knowledge, this is the first reported case in the English-language literature of such an entity in the pediatric age group. 相似文献
26.
Preemptive Plasmapheresis and Recurrence of FSGS in High-Risk Renal Transplant Recipients 总被引:2,自引:0,他引:2
R. Y. Gohh A. F. Yango P. E. Morrissey A. P. Monaco A. Gautam M. Sharma E. T. McCarthy V. J. Savin 《American journal of transplantation》2005,5(12):2907-2912
Recurrent focal segmental glomerulosclerosis (FSGS) following transplantation is ascribed to the presence of a circulating FSGS permeability factor (FSPF). Plasmapheresis (PP) can induce remission of proteinuria in recurrent FSGS. This study addressed the efficacy of pre-transplant PP in decreasing the incidence of recurrence in high-risk patients. Ten patients at high-risk for FSGS recurrence because of rapid progression to renal failure (n = 4) or prior transplant recurrence of FSGS (n = 6) underwent a course of 8 PP treatments in the peri-operative period. Recurrences were identified by proteinuria >3 g/day and confirmed by biopsy. Seven patients, including all 4 with first grafts and 3 of 6 with prior recurrence, were free of recurrence at follow-up (238-1258 days). Final serum creatinine in 8 patients with functioning kidneys averaged 1.53 mg/dL. FSGS recurred within 3 months in 3 patients, each of whom had lost prior transplants to recurrent FSGS. Two of these progressed to end-stage renal disease (ESRD) and the third has significant renal dysfunction. Based on inclusion criteria, recurrence rates of 60% were expected if no treatment was given. Therefore, PP may decrease the incidence of recurrent FSGS in high-risk patients. Definitive conclusions regarding optimal management can only be drawn from larger, randomized, controlled studies. 相似文献
27.
Macroglossia and amyloidoma of the buttock: evidence of systemic involvement in dialysis amyloid 总被引:2,自引:0,他引:2
D Sethi A J Hutchison N R Cary E A Brown J R Curtis D F Woodrow P E Gower 《Nephron》1990,55(3):312-315
A 48-year-old male on cuprophane haemodialysis for 18 years, with a history of dialysis arthropathy and recurrent carpal tunnel syndrome developed macroglossia and bilateral buttock tumoral masses. The tongue and buttock masses were biopsied. Histology of both biopsies showed amyloid deposits of the beta 2-microglobulin (B2M) variety. Amyloidomas in the gluteal region and macroglossia have not been previously described in amyloid derived from B2M. These findings suggest that systemic B2M amyloidosis can have a similar tissue distribution to AL amyloidosis. This case also stresses the importance of inspection of the tongue, and palpation of the gluteal region for masses, in the assessment of patients with dialysis arthropathy. 相似文献
28.
Chakraborty S Garg P Ramamurthy T Thungapathra M Gautam JK Kumar C Maiti S Yamasaki S Shimada T Takeda Y Ghosh A Nair GB 《Journal of medical microbiology》2001,50(10):879-888
This study identified 17 matching serogroups of Vibrio cholerae belonging to serogroups other than O1 and O139 isolated from human cases and from the environment during a concurrent clinical and environmental study conducted in Calcutta, a cholera endemic area. Isolates within these matching serogroups were compared by various phenotypic and genotypic traits to determine if the environment was the source of the organisms associated with the disease. Clinical strains of V. cholerae were resistant to a greater number of drugs and exhibited multi-drug resistance compared with their environmental counterparts. Except for the presence of the genes for the El Tor haemolysin and the regulatory element ToxR in most of the strains of V. cholerae examined, non-O1, non-O139 V. cholerae strains lacked most of the other known virulence traits associated with toxigenic V. cholerae O1 or O139. Restriction fragment-length polymorphism of virulence-associated genes, ribotypes and DNA fingerprints of strains of matched serogroups showed considerable diversity, although some gene polymorphisms and ribotypes of a few strains of different serogroups were similar. It is concluded that despite sharing the same serogroup, environmental and clinical isolates were genetically heterogeneous and were of different lineages. 相似文献
29.
Alan Ma Sunita Gurnasinghani Edwin P. Kirk Conor McClenaghan Gautam K. Singh Dorothy K. Grange Chetan Pandit Yung Zhu Tony Roscioli George Elakis Michael Buckley Bhavesh Mehta Philip Roberts Jonathan Mervis Andrew Biggin Colin G. Nichols 《American journal of medical genetics. Part A》2019,179(8):1585-1590
Cantú syndrome (CS), characterized by hypertrichosis, distinctive facial features, and complex cardiovascular abnormalities, is caused by pathogenic variants in ABCC9 and KCNJ8 genes. These genes encode gain‐of‐function mutations in the regulatory (SUR2) and pore‐forming (Kir6.1) subunits of KATP channels, respectively, suggesting that channel‐blocking sulfonylureas could be a viable therapy. Here we report a neonate with CS, carrying a heterozygous ABCC9 variant (c.3347G>A, p.Arg1116His), born prematurely at 32 weeks gestation. Initial echocardiogram revealed a large patent ductus arteriosus (PDA), and high pulmonary pressures with enlarged right ventricle. He initially received surfactant and continuous positive airway pressure ventilation and was invasively ventilated for 4 weeks, until PDA ligation. After surgery, he still had ongoing bilevel positive airway pressure (BiPAP) requirement, but was subsequently weaned to nocturnal BiPAP. He was treated for pulmonary hypertension with Sildenafil, but failed to make further clinical improvement. A therapeutic glibenclamide trial was commenced in week 11 (initial dose of 0.05 mg–1 kg–1 day–1 in two divided doses). After 1 week of treatment, he began to tolerate time off BiPAP when awake, and edema improved. Glibenclamide was well tolerated, and the dose was slowly increased to 0.15 mg?1 kg?1day?1 over the next 12 weeks. Mild transient hypoglycemia was observed, but there was no cardiovascular dysfunction. Confirmation of therapeutic benefit will require studies of more CS patients but, based on this limited experience, consideration should be given to glibenclamide as CS therapy, although problems associated with prematurity, and complications of hypoglycemia, might limit outcome in critically ill neonates with CS. 相似文献
30.
The peripheral muscle membrane protein rapsyn is essential for the formation and maintenance of high density acetylcholine receptor aggregates at the neuromuscular synapse. Rapsyn is concentrated at synaptic sites and is colocalized with acetylcholine receptors from the earliest stages of synaptogenesis. Previous studies have shown that recombinant rapsyn expressed in heterologous cells forms clusters, and acetylcholine receptors coexpressed with rapsyn are colocalized with rapsyn clusters. However, the molecular interactions involved in clustering of rapsyn are not well defined. To analyze the process of cluster formation by rapsyn we examined the formation of rapsyn clusters and complexes using mutant constructs specifically deleted for individual domains of rapsyn in the presence and absence of tagged, full-length rapsyn. Specific deletions of the tetratricopeptide repeat (TPR) domains 1 and 3 of rapsyn abrogated not only clustering of mutant rapsyns, but also, in a dominant negative fashion, the clustering of tagged, full-length rapsyn. We also analyzed rapsyn protein complexes isolated from cells transfected with tagged and untagged rapsyn. Our results show that both tagged and untagged rapsyn are present in immunoprecipitates of rapsyn from cotransfected cells, demonstrating that rapsyn molecules interact directly or indirectly to form oligomers. Mutants that were dominant negatives were also present in complexes containing tagged, full-length rapsyn. Together these results indicate that rapsyn forms clusters at the synapse by oligomerization, and suggest models for the mechanistic bases of this oligomerization via interactions mediated by TPRs 1 and 3. 相似文献