全文获取类型
收费全文 | 4163篇 |
免费 | 160篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 89篇 |
儿科学 | 64篇 |
妇产科学 | 51篇 |
基础医学 | 507篇 |
口腔科学 | 72篇 |
临床医学 | 291篇 |
内科学 | 1437篇 |
皮肤病学 | 31篇 |
神经病学 | 313篇 |
特种医学 | 79篇 |
外科学 | 666篇 |
综合类 | 9篇 |
预防医学 | 109篇 |
眼科学 | 60篇 |
药学 | 276篇 |
中国医学 | 4篇 |
肿瘤学 | 303篇 |
出版年
2023年 | 31篇 |
2022年 | 64篇 |
2021年 | 137篇 |
2020年 | 80篇 |
2019年 | 99篇 |
2018年 | 129篇 |
2017年 | 84篇 |
2016年 | 93篇 |
2015年 | 90篇 |
2014年 | 134篇 |
2013年 | 156篇 |
2012年 | 295篇 |
2011年 | 269篇 |
2010年 | 170篇 |
2009年 | 169篇 |
2008年 | 250篇 |
2007年 | 278篇 |
2006年 | 274篇 |
2005年 | 282篇 |
2004年 | 249篇 |
2003年 | 236篇 |
2002年 | 204篇 |
2001年 | 32篇 |
2000年 | 36篇 |
1999年 | 34篇 |
1998年 | 37篇 |
1997年 | 22篇 |
1996年 | 28篇 |
1995年 | 14篇 |
1994年 | 26篇 |
1993年 | 16篇 |
1992年 | 29篇 |
1991年 | 15篇 |
1990年 | 14篇 |
1989年 | 15篇 |
1988年 | 19篇 |
1987年 | 11篇 |
1986年 | 20篇 |
1985年 | 20篇 |
1984年 | 18篇 |
1983年 | 22篇 |
1982年 | 13篇 |
1981年 | 12篇 |
1979年 | 15篇 |
1978年 | 14篇 |
1977年 | 16篇 |
1976年 | 11篇 |
1975年 | 10篇 |
1974年 | 13篇 |
1973年 | 10篇 |
排序方式: 共有4361条查询结果,搜索用时 15 毫秒
61.
Antonio Pesce Gaetano Piccolo Francesca Lecchi Nicol Fabbri Michele Diana Carlo Vittorio Feo 《World journal of gastroenterology : WJG》2021,27(36):5989-6003
Laparoscopic cholecystectomy (LC) is one of the most frequently performed gastrointestinal surgeries worldwide. Bile duct injury (BDI) represents the most serious complication of LC, with an incidence of 0.3%-0.7%, resulting in significant perioperative morbidity and mortality, impaired quality of life, and high rates of subsequent medico-legal litigation. In most cases, the primary cause of BDI is the misinterpretation of biliary anatomy, leading to unexpected biliary lesions. Near-infrared fluorescent cholangiography is widely spreading in clinical practice to delineate biliary anatomy during LC in elective and emergency settings. The primary aim of this article was to perform an up-to-date overview of the evolution of this method 12 years after the first clinical application in 2009 and to highlight all advantages and current limitations according to the available scientific evidence. 相似文献
62.
Mario Cazzola Paolo Arosio Vittorio Bellotti Gaetano Bergamaschi Laura Dezza Carmelo Iacobello† Giuseppina Ruggeri† 《British journal of haematology》1985,61(3):445-453
Immunoassays for acidic ferritins rich in H subunits have shown that these isoferritins are predominant in some cells such as monocytes and red blood cells but have provided conflicting results about their presence in human serum. We have used an immunoradiometric assay based on a monoclonal antibody against human heart ferritin (monoclonal 2A4) for evaluating acidic ferritin concentration in human serum. This assay proved to be highly specific for acidic isoferritins having more than 60% H subunits. Heart-type ferritin was detected in only one fifth of normal sera and sera from patients with iron overload; values were very low compared with those for basic ferritin. Acidic ferritin was found in relatively high concentrations in most patients with iron deficiency anaemia. In other disease states characterized by increased serum concentrations of basic ferritin, acidic ferritin was always less than 21% of the total ferritin. Dialysis in low-ionic-strength buffer showed that both normal and pathological sera had binding factors for human heart ferritin. We conclude that: (i) human serum contains low concentrations of acidic isoferritins which, at variance with basic ferritin, do not appear to be directly related to the amount of storage iron; (ii) the findings of the present study reinforce the opinion that basic and acidic ferritins have different functional behaviours. 相似文献
63.
A V Greco G Mingrone C Raguso A Tataranni E Finotti R M Tacchino E Capristo A De Gaetano M Castagneto 《Annals of nutrition & metabolism》1992,36(1):1-11
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. We investigated its pharmacokinetic profile and thermogenic effect during a short-time infusion (5 h at 10 g/h) in 7 male volunteers. Sebacate in serum and urine was measured by high-performance liquid chromatography. A single-compartment model with two linear elimination routes was fitted. Metabolic measurements (VO2, VCO2, respiratory quotient, metabolic rate) were continuously performed for 8 h (5 h during and 3 h after the infusion) by a canopy indirect calorimeter. The apparent volume of distribution of sebacate was 8.39 +/- 0.69 liters, and the plasma fractional removal rate constant was 0.0086 +/- 0.00077 min-1. The average half-life and plasma clearance were 80.6 min and 72 ml/min, respectively. The increase in metabolic rate, the decrease in respiratory quotient and the changes in ketone body, glucagon and insulin levels during the infusion were not significant. 24-hour catecholamine excretion was within normal limits. Calories administered by sebacate seem to be available for utilization without relevant metabolic side effects. 相似文献
64.
65.
66.
67.
68.
69.
70.
Colao A Di Somma C Rota F Di Maio S Salerno M Klain A Spiezia S Lombardi G 《The Journal of clinical endocrinology and metabolism》2005,90(5):2659-2665
We prospectively investigated the risk of early atherosclerosis, by classical cardiovascular risk factors and intima-media thickness (IMT) at the common carotid arteries, in 23 adolescents diagnosed as GH deficient (GHD) during childhood and in 23 healthy sex-, age-, and BMI-matched controls. Measurements were performed in all subjects before stopping GH replacement. Because the diagnosis of GHD had been confirmed in 15 of the 23 adolescents, the protocol changed according to the diagnosis as follows: measurements were repeated after 6 months of GH withdrawal and 6 months of GH reinstitution in the 15 with GHD, and after 6 and 12 months of GH withdrawal, measurements were also taken in the eight non-GHD subjects. Serum IGF-I levels were in the normal range for age in all patients before GH withdrawal. When compared with controls, before GH withdrawal, GHD adolescents had reduced high-density lipoprotein cholesterol levels and increased total/high-density lipoprotein cholesterol ratio, fibrinogen, low-density lipoprotein cholesterol, and glucose levels; non-GHD adolescents had increased glucose, insulin, and homeostasis model assessment score. IMT at the common carotid arteries was similar in GHD and controls (0.52 +/- 0.03 vs. 0.55 +/- 0.06 mm; P = 0.23) and was higher in non-GHD than in controls (0.62 +/- 0.03 vs. 0.54 +/- 0.06 mm; P = 0.01). In GHD adolescents, 6 months of GH treatment withdrawal and 6 months of GH treatment reinstitution modified IGF-I levels, lipid profile, and insulin resistance but not IMT or systolic and diastolic peak velocities at the common carotid arteries. In non-GHD subjects, 12 months of GH treatment withdrawal significantly decreased IGF-I levels, IMT (to 0.54 +/- 0.06 mm; P < 0.001 vs. baseline), systolic and diastolic peak velocities, and improved insulin resistance. In conclusion, the discontinuation of GH in confirmed GHD adolescents is not followed by significant alterations of the common carotid arteries, despite the profound negative alterations of the lipid profile. In adolescents who were not confirmed to have GHD, IMT was increased while on GH therapy and normalized when they were taken off of GH. 相似文献