学龄前儿童心理行为问题与家长健康素养的关系

目的探讨家长健康素养与学龄前儿童心理行为问题的关系,为学龄前儿童心理行为问题早期干预提供参考。方法 2018年5-7月采用分层整群随机抽样的方法,抽取深圳市光明区13所幼儿园4 120名学龄前儿童及其家长,使用长处与困难问卷(SDQ)家长版和深圳市居民健康素养问卷分别对学龄前儿童心理行为问题及家长健康素养水平进行调查;采用非条件Logistic回归分析家长健康素养与儿童心理行为问题的关系。结果学龄前儿童心理行为问题检出率为34.9%(1 436/4 120)。其中困难总分6.5%、情绪问题5.6%、品行问题8.9%、多动注意不能13.4%、同伴交往问题14.4%、亲社会行为9.2%。男童和女童困难总分、情绪问题、品行问题、多动注意不能、同伴交往问题、亲社会行为检出率分别为7.3%和5.5%,4.8%和6.5%,9.7%和7.8%,15.5%和10.7%,15.8%和12.7%,11.1%和6.7%,差异有统计学意义(χ^2值分别为5.626,5.506,4.212,19.846,7.650,23.863,P<0.05)。多因素Logistic回归分析显示,家长健康素养(OR=1.294)、健康知识(OR=1.293)、健康行为(OR=1.412)及健康技能(OR=1.193)水平低是学龄前儿童心理行为问题产生的危险因素(P<0.05)。结论学龄前儿童心理行为问题发生率较高,问题突出,家长健康素养水平低是学龄前儿童心理行为问题的重要影响因素。     

Resistin is elevated in cystic fibrosis sputum and correlates negatively with lung function

Background

Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. Here we assessed the relationship of resistin to CF lung disease.

健脾消积颗粒对脾胃湿热型功能性消化不良患儿的临床疗效及对脑肠肽水平的影响＊

目的 探讨健脾消积颗粒治疗脾胃湿热型功能性消化不良的临床疗效及其对脑肠肽的影响。方法 按照随机数字表法将2018年2月-2019年2月我院收治的80例功能性消化不良患儿均分为对照组和观察组，对照组给予多潘立酮片治疗，观察组在对照组基础上加用健脾消积颗粒治疗，比较2组治疗效果。结果 治疗后2组主要临床症状积分均显著下降，观察组下降更为明显。观察组总有效率为95%，显著高于对照组的79.5%。观察组治疗后胃电节律异常例数明显低于对照组，治疗后2组胃动素(MTL)显著上升，神经肽Y（NPY）、神经降压素（NT）显著下降，且观察组和对照组相比，差异有统计学意义。2组治疗期间均未发生不良反应及肝肾功能异常。结论 健脾消积颗粒能够明显改善脾胃湿热型功能性消化不良患儿临床症状，改善胃动力水平，调节脑肠肽分泌水平。     

滋阴药延缓衰老机制的研究进展＊

当代社会，老年人口比例呈现不断上升的趋势，老龄化问题日益严峻。因此，如何有效地延缓衰老不仅成为了世界医学研究的热点，也成为了全球亟待解决的问题。中医药在延缓衰老方面经验丰富，而滋阴药在此类研究中效果显著。本文通过整理滋阴药抗衰老作用机制的若干文献，对滋阴复方六味地黄丸、二至丸、左归丸及其他滋阴中药延缓衰老的机制研究进展进行综述。     

空间频域成像在皮肤病定量评估中的研究

利用空间频域成像技术搭建的成像系统检测多种皮肤病组织的光学参数和生理参数信息，并对比分析讨论不同类型的皮肤病与光学参数、生理参数之间的关系。实验结果表明，病变皮肤组织与正常皮肤组织之间在光学参数、生理参数上存在较大差异，这将为临床医生对皮肤病诊治提供一种新颖、可靠、科学的评估方法。     

膀胱肿瘤切除术后尿路感染病原学和危险因素

目的观察膀胱肿瘤切除术后患者尿路感染发生情况与病原学特征,分析诱发尿路感染的危险因素,并提出合理且具备针对性的冲洗对策,为未来膀胱肿瘤切除术后尿路感染的预防提供合理参考。方法回顾性分析连云港市第一人民医院2016年1月-2019年1月接受经尿道膀胱肿瘤切除术治疗的451例膀胱肿瘤患者的临床资料,收集患者病例资料,全部患者术后均定期取尿液标本进行细菌培养,参照相关标准判定患者尿路感染情况,记录患者一般情况,包括一般人口学资料(性别、年龄、体质量、受教育程度等),同时记录患者糖尿病的疾病合并情况,将术后尿路感染可能的危险因素纳入初步分析,Logistic多因素回归分析膀胱肿瘤切除术后发生尿路感染的危险因素。结果451例膀胱肿瘤切除术患者术后第3天尿液中细菌培养阳性例数为80例,阳性率为17.74%,在使用抗菌药物后,患者尿液中细菌培养阳性率逐渐降低,各时点尿液细菌阳性培养率比较,差异有统计学意义(P<0.05);经多因素Logistic回归分析检验证实,高龄、血糖水平控制不佳、术前留置导尿管、多发肿瘤是膀胱肿瘤切除术后尿路感染的危险因素(OR>1,P<0.05);80例术后尿液细菌培养阳性患者共分离出87株菌株,其中革兰阴性菌66株占75.86%,革兰阳性球菌21株占24.14%。结论膀胱肿瘤切除术后患者有较高的尿路感染风险,革兰阴性菌是主要的感染病原菌,年龄、基础疾病、肿瘤位点、术前导尿管留置等是影响因素,这类患者应引起临床高度重视。     

Association Study of Matrix Metalloproteinases Gene Polymorphisms with Susceptibility to Rheumatoid Arthritis: A Meta-Analysis

Objective: Association of matrix metalloproteinases (MMPs) gene polymorphisms with rheumatoid arthritis is controversial. We conduct a meta-analysis to clarify this dispute.

Methods: We systematically searched the electronic PUBMED, EMBASE and CNKI databases for research articles about MMPs (MMP-1, MMP-2, MMP-3, MMP-9) gene polymorphisms and rheumatoid arthritis (RA) up to January 2015. According to the heterogeneity, fixed-effects or random-effects models were used to calculate crude odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results: A total of 11 articles involving 2143 cases and 2049 controls were included in this meta-analysis. Overall, no significant associations were observed between MMP-1-1607 1G/2G polymorphism and RA. Stratification by ethnicity, no significant associations were observed in Caucasian populations. Similarly, no significant associations were observed between MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms and RA in overall and Caucasian populations, respectively. However, a weak association was found between MMP-2-1306 C/T polymorphism and RA (C vs. T, OR?=?0.813, 95%CI?=?0.694–0.953, p?=?0.010) in overall populations.

Conclusions: The present meta-analysis suggests that MMP-1-1607 1G/2G, MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms are not associated with the susceptibility of RA, but MMP-2 -1306 C/T is weakly associated with susceptibility to RA. Further studies with more sample size are needed for definitive conclusions.