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201.
Dear Professor Lian-Sheng Ma Professor Michael Hobsley I have greatly enjoyed reading the account of all you have done towards the development of "The World Journal of Gastroenterology" as described in the article by Zhen-Xi Li in the November st. Issue of the Journal.…… 《World journal of gastroenterology : WJG》2007,13(1):158-158
Dear Professor Lian-Sheng Ma,
Professor Michael Hobsley and I have greatly enjoyed reading the account of all you have done towards the development of "The World Journal of Gastroenterology", as described in the article by Zhen-Xi Li in the November 21st. Issue of the Journal. 相似文献
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Positive predictive value of maximal posterior joint-line tenderness in diagnosing meniscal pathology: a pilot study 下载免费PDF全文
Veronica M.R. Wadey Nicholas G.H. Mohtadi Robert C. Bray Cyril B. Frank 《Canadian journal of surgery》2007,50(2):96-100
OBJECTIVE: The purpose of this prospective study was to determine the positive predictive value (PPV) of the point of maximal posterior joint line tenderness (JLT), as a clinical sign, to diagnose underlying meniscal tears. METHODS: We conducted a prospective study of patients requiring arthroscopic surgery, who consecutively presented to the University of Calgary's Sport Medicine Centre. The femurotibial joint line was palpated for the point of maximal tenderness. We recorded the data on the arthroscopy report. A second examiner (orthopedic sport medicine surgical fellow or sport medicine physician) performed the same protocol. An arthroscopist documented the site of pathology as detected by arthroscopy. RESULTS: We found a PPV of 60.0% and a negative predictive value of 62.5%, suggesting that maximal posterior JLT may be predictive of meniscal pathology. The sensitivity and specificity were 84.6% and 31.2%, respectively (p = 0.155), with Fisher's exact test. The kappa score assessed interobserver reliability and was good at 0.48. Patients with maximal posterior JLT but no meniscal pathology did have other confounding pathology and patients with no maximal posterior JLT who had meniscal pathology usually had confounding knee pathology. CONCLUSIONS: We found a PPV of 60.0% of maximal posterior JLT and meniscal pathology located at the same anatomical site on arthroscopic examination. 相似文献
204.
The prevalence of adult smoking in the United States declined from 42.4% in 1965 to 20.9% in 2005. Much of the success in
reducing the prevalence of adult smoking over the past four decades can be attributed to tobacco control policies. This paper
provides an overview of public health initiatives for smoking cessation in the United States and provides a review of the
existing literature on the effects of these tobacco control initiatives on adult smoking cessation. 相似文献
206.
Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats 总被引:1,自引:0,他引:1
Michael Schwarz Bertram Poch Rainer Isenmann Dietrich Kriese Eva Rozdzinski Hans G. Beger Frank Gansauge 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2007,392(3):365-370
Background The clinical course in acute necrotizing pancreatitis is mainly determined by bacterial infection of pancreatic and peripancreatic
necrosis. The effect of two antibiotic regimens for early and late treatment was investigated in the taurocholate model of
necrotizing pancreatitis in the rat.
Materials and methods Seventy male Wistar rats were divided into five pancreatitis groups (12 animals each) and a sham-operated group (10 animals).
Pancreatitis was induced by intraductal infusion of 3% taurocholate under sterile conditions. Animals received two different
antibiotic regimes (20 mg/kg imipenem or 20 mg/kg ciprofloxacin plus 20 mg/kg metronidazole) early at 2, 12, 20, and 28 h
after induction of pancreatitis or late at 16 and 24 h after induction of pancreatitis or no antibiotics (control). Animals
were examined after 30 h for pancreatic and extrapancreatic infection.
Results Early and late antibiotic treatment with both regimes could significantly reduce pancreatic infection from 58 to 8–25%. However,
extrapancreatic infection was only reduced by early antibiotic therapy. While quinolones also reduced bacterial counts in
small and large bowel, imipenem did not.
Conclusions In our animal model of necrotizing pancreatitis, early and late treatment with ciprofloxacin/metronidazole and imipenem reduce
bacterial infection of the pancreas. Extrapancreatic infection, however, is reduced significantly only by early antibiotic
treatment. The effectivity of early antibiotic treatment in the clinical setting should be subject to further investigation
with improved study design and sufficient patient numbers. 相似文献
207.
Magnetically-labeled sensitized splenocytes to identify glioma by MRI: a preliminary study. 总被引:1,自引:0,他引:1
Ali S Arbab Ali M Rad A S M Iskander Kourosh Jafari-Khouzani Stephen L Brown Jamie L Churchman Guangliang Ding Quan Jiang Joseph A Frank Hamid Soltanian-Zadeh Donald J Peck 《Magnetic resonance in medicine》2007,58(3):519-526
This study investigated the feasibility of imaging the migration and incorporation of magnetically-labeled sensitized splenocytes in an experimental 9L glioma brain tumor model. Splenocytes collected from tumor-bearing (sensitized splenocytes) or control (nonsensitized splenocytes) host rats were analyzed to determine the population of different cells, labeled with ferumoxides-protamine sulfate (FePro) and injected intravenously to recipient rats (N=4, for each group) bearing intracranial 9L tumors. Day 3 postinjection of splenocytes multiecho T2*-weighted and three-dimensional (3D) gradient echo MRI were obtained using a 7 Tesla MR system. R2* (1/T2*) maps were created from the T2*-weighted images. Signal intensities (SIs) and R2* values in the tumors and contralateral brain were determined by hand drawn regions of interest (ROIs). Brain sections were stained for the evidence of administered cells. Both 3D and T2*-weighted MRI showed low signal intensity areas in and around the tumors in rats that received labeled sensitized splenocytes. Prussian blue (PB), CD45- and CD8-positive cells were present in areas at the corresponding sites of low signal intensities seen on MRI. Rats that received labeled nonsensitized splenocytes did not show low signal intensity areas or PB positive cells in or around the implanted tumors. In conclusion, the immunogenic reaction can be exploited to delineate recurrent glioma using MRI following systemically delivered magnetically labeled sensitized splenocytes or T-cells. 相似文献
208.
209.
Steven J. Davidson MD MBA Frank L. Zwemer Jr. MD MBA Larry A. Nathanson MD Kenneth N. Sable MD Abu N.G.A. Khan MD MS 《Academic emergency medicine》2004,11(11):1127-1134
Physician-generated emergency department clinical documentation (information obtained from clinician observations and summarized decision processes inclusive of all manner of electronic systems capturing, storing, and presenting clinical documentation) serves four purposes: recording of medical care and communication among providers; payment for hospital and physician; legal defense from medical negligence allegations; and symptom/disease surveillance, public health, and research functions. In the consensus development process described by Handler, these objectives were balanced with the consideration of efficiency, often evaluated as physician time and clinical documentation system costs, in recording the information necessary for their accomplishment. The consensus panel session participants and authors recommend that 1) clinical documentation be electronically retrievable; 2) selection and implementation be evidence-based and grounded on valid metrics (research is needed to identify these metrics); 3) the user interface be crafted to promote clinical excellence through high-quality information collection and efficient charting techniques; 4) the priorities for integration of clinical information be standardized and implemented within enterprises and across health and information systems; 5) systems use accepted standards for bidirectional, real-time clinical data exchange, without limiting the location or number of simultaneous users; 6) systems fully utilize existing electronic sources of specific patient information and general medical knowledge; 7) systems automatically and reliably capture appropriate data that support electronic billing for emergency department services; and 8) systems promote bedside documentation and mobile access. 相似文献
210.