全文获取类型
收费全文 | 567篇 |
免费 | 59篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 40篇 |
妇产科学 | 1篇 |
基础医学 | 46篇 |
口腔科学 | 14篇 |
临床医学 | 43篇 |
内科学 | 92篇 |
皮肤病学 | 6篇 |
神经病学 | 25篇 |
特种医学 | 90篇 |
外科学 | 53篇 |
综合类 | 11篇 |
预防医学 | 68篇 |
眼科学 | 62篇 |
药学 | 28篇 |
肿瘤学 | 39篇 |
出版年
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 5篇 |
2018年 | 12篇 |
2017年 | 12篇 |
2016年 | 11篇 |
2015年 | 16篇 |
2014年 | 25篇 |
2013年 | 24篇 |
2012年 | 18篇 |
2011年 | 15篇 |
2010年 | 17篇 |
2009年 | 22篇 |
2008年 | 13篇 |
2007年 | 10篇 |
2006年 | 15篇 |
2005年 | 15篇 |
2004年 | 12篇 |
2003年 | 23篇 |
2002年 | 18篇 |
2001年 | 24篇 |
2000年 | 13篇 |
1999年 | 13篇 |
1998年 | 23篇 |
1997年 | 28篇 |
1996年 | 27篇 |
1995年 | 15篇 |
1994年 | 25篇 |
1993年 | 15篇 |
1992年 | 14篇 |
1991年 | 17篇 |
1990年 | 8篇 |
1989年 | 10篇 |
1988年 | 12篇 |
1987年 | 13篇 |
1986年 | 5篇 |
1985年 | 13篇 |
1984年 | 9篇 |
1983年 | 4篇 |
1982年 | 9篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1979年 | 2篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 6篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有628条查询结果,搜索用时 31 毫秒
71.
Quantitative liver function in patients with rheumatoid arthritis treated with low-dose methotrexate: a longitudinal study 总被引:4,自引:0,他引:4
Beyeler C; Reichen J; Thomann SR; Lauterburg BH; Gerber NJ 《Rheumatology (Oxford, England)》1997,36(3):338-344
The objectives were to determine quantitative liver function prospectively
in patients with rheumatoid arthritis (RA) treated with low-dose
methotrexate (MTX), to search for risk factors for a loss of quantitative
liver function and to assess the relationship between quantitative liver
function and histological staging. A total of 117 patients with RA (ACR
criteria, 85 women, mean age 59 yr) had measurements of galactose
elimination capacity (GEC), aminopyrine breath test (ABT) and liver enzymes
[aspartate amino transferase (AST), alanine amino transferase (ALT),
alkaline phosphatase (AP), 7-glutamyl transferase (GGT), bile acids,
bilirubin, albumin] before treatment with weekly i.m. MTX injections and
every year thereafter. In 16 patients, liver biopsies were performed.
Before the introduction of MTX, mean GEC was 6.6 mg/min/kg [5th to 95th
percentile (5-95 PC) 5.1- 8.5; reference range 6.0-9.1] and mean ABT was
0.80% kg/mmol (5-95 PC 0.42-1.30: reference range 0.6-1.0). During
treatment with MTX [mean weekly dose 11.8 mg (5-95 PC 5.4-20.2), mean
observation period 3.8 yr (5-95 PC 0.4-6.9)], significant declines of GEC
(-0.12 mg/min/kg per year. t = 3.30, P < 0.002) and ABT (-0.06% kg/mmol
per year, t = 4.81, P < 0.001) were observed. Negative correlations were
found between the annual change in GEC and GEC at baseline (Rs = -0.40, P
< 0.0001), and the annual change in ABT and ABT at baseline (Rs = -0.43,
P < 0.0001). No correlations were found between the annual change in GEC
or ABT and weekly MTX dose, age or percentage of increased liver enzymes,
and no effect of a history of alcohol consumption > 30 g/week became
evident. Two patients with Roenigk grade III had impaired quantitative
liver function, while 14 patients with Roenigk grades I and II exhibited a
high variability of GEC and ABT from normal to abnormal values. The
continuous declines in GEC and ABT observed deserve attention in patients
with prolonged treatment. Patients with a low GEC or ABT at baseline seem
not to be at increased risk for a further loss of quantitative liver
function. An impaired GEC or ABT does not necessarily concur with hepatic
fibrosis on histological examination.
相似文献
72.
73.
74.
Assessment by dipyridamole-thallium-201 myocardial scintigraphy of coronary risk before peripheral vascular surgery 总被引:4,自引:0,他引:4
R N Sachs P Tellier P Larmignat J Azorin L Fischbein B Beaudet P Cadilhac M Cupa G De Saint Florent M Vulpillat 《Surgery》1988,103(5):584-587
From October 1983 to January 1985, 46 patients (38 men and 8 women; average age, 60 years; range, 37 to 83 years) underwent peripheral vascular surgery of either the internal carotid artery or the arteries of the lower limbs. Each patient had a thorough clinical examination, an ECG, and a dipyridamole-thallium-201 myocardial scan before operation. On the basis of results, they were divided into two groups: 20 patients with and 26 patients without chronic ischemic heart disease. Three major cardiac events were noted during or after a period of 1 month after surgery: There were two deaths due to cardiac ischemic events and one patient had postoperative unstable angina pectoris. These three patients were classified in the coronary group (NS). When the patients were classified on the basis of whether or not there was thallium redistribution on serial images after infusion of dipyridamole, 14 with redistribution and 32 without redistribution were noted. The three patients who had major cardiac events were in the former group (p less than 0.04). Our data suggest that patients in whom redistribution occurs have a high incidence of postoperative ischemic events. These patients should be considered for particular preoperative coronary care to avoid major postoperative cardiac events and to increase chances of survival. 相似文献
75.
The use of computed tomography in recurrent rectal tumors 总被引:5,自引:1,他引:4
76.
77.
78.
Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain 总被引:3,自引:0,他引:3
79.
80.
Quantitative coronary arteriography: design and validation 总被引:1,自引:0,他引:1
The authors assessed the performance of an automatic and rapid coronary quantification method by evaluating its accuracy in a stenosis phantom. Measurements were obtained with a lucite phantom with 2-, 3-, and 4-mm vessel diameters and concentric stenoses of 33%, 50%, 67%, and 75%. Direct digital angiographic images as well as 10 X 10 spot films and 35-mm cine angiography films were acquired with and without structural noise and mask subtraction. The films were digitized with magnification factors of one and two. An interactive analysis program was used to automatically determine the vessel edges with a Gaussian fit to the cross-sectional density profiles perpendicular to the center line of the vessel. Relative changes of the densitometric cross-sectional area along the vessel were used to assess the percentage of stenosis. Densitometric measurements were comparable in both digital and cine angiograms (r = .99 and r = .98, respectively); however, diameter measurements showed a higher variability and were dependent on the amount of magnification applied to the images. 相似文献