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881.
882.
Teriparatide vs. calcitonin in the treatment of Asian postmenopausal women with established osteoporosis 总被引:4,自引:0,他引:4
J. S. Hwang S. T. Tu T. S. Yang J. F. Chen C. J. Wang K. S. Tsai 《Osteoporosis international》2006,17(3):373-378
This study compared the clinical efficacy, safety, and tolerability of daily subcutaneous injections of teriparatide and salmon
calcitonin in the treatment of postmenopausal women with established osteoporosis in Taiwan. This 6-month, multicenter, randomized,
controlled study enrolled 63 women with established osteoporosis. They were randomized to receive either teriparatide 20 μg
or calcitonin 100 IU daily in an open-label fashion. Lumber spine, femoral neck, total hip bone mineral density (BMD), and
biochemical markers of bone turnover were measured, and adverse events and tolerability were recorded. The results at 6 months
showed that patients using teriparatide had larger mean increases in spinal BMD than those who used calcitonin (4.5% vs. 0.1%),
but the BMD changes in these two groups at the femoral neck and the total hip were not significant. There were also larger
mean increases in bone markers in the teriparatide group than in the calcitonin group (bone specific alkaline phosphatase
142% vs. 37%; osteocalcin 154% vs. 23%). We conclude that teriparatide has more positive effects on bone formation than salmon
calcitonin, as shown by the larger increments of lumbar spine BMD and bone formation markers, and caused only mild adverse
events and no significant change in liver, kidney or hematological parameters. Compared with the published global results,
teriparatide seems to be equally effective and safe to use in this Asian population. 相似文献
883.
F. Madsen 《Clinical and experimental allergy》2006,36(6):850-851
884.
885.
Najat C Daw Wayne L Furman Clinton F Stewart Lisa C Iacono Mark Krailo Mark L Bernstein Janet E Dancey Rose Anne Speights Susan M Blaney James M Croop Gregory H Reaman Peter C Adamson 《Journal of clinical oncology》2005,23(25):6172-6180
PURPOSE: Epidermal growth factor receptor is expressed in pediatric malignant solid tumors. We conducted a phase I trial of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in children with refractory solid tumors. PATIENTS AND METHODS: Gefitinib (150, 300, 400, or 500 mg/m2) was administered orally to cohorts of three to six patients once daily continuously until disease progression or significant toxicity. Pharmacokinetic studies were performed during course one (day 1 through 28). RESULTS: Of the 25 enrolled patients, 19 (median age, 15 years) were fully evaluable for toxicity and received 54 courses. Dose-limiting toxicity was rash in two patients treated with 500 mg/m2 and elevated ALT and AST in one patient treated with 400 mg/m2. The maximum-tolerated dose was 400 mg/m2/d. The most frequent non-dose-limiting toxicities were grade 1 or 2 dry skin, anemia, diarrhea, nausea, and vomiting. One patient with Ewing's sarcoma had a partial response. Disease stabilized for 8 to > or = 60 weeks in two patients with Wilms' tumor and two with brainstem glioma (one exophytic). At 400 mg/m2, the median peak gefitinib plasma concentration was 2.2 microg/mL (range, 1.2 to 3.6 microg/mL) and occurred at a median of 2.3 hours (range, 2.0 to 8.3 hours) after drug administration. The median apparent clearance and median half-life were 14.8 L/h/m2 (range, 3.8 to 24.8 L/h/m2) and 11.7 hours (range, 5.6 to 22.8 hours), respectively. Gefitinib systemic exposures were comparable with those associated with antitumor activity in adults. CONCLUSION: Oral gefitinib is well tolerated in children. Development of the drug in combination with cytotoxic chemotherapy will be pursued. 相似文献
886.
G. B. Slepchenko L. S. Anisimova V. F. Slipchenko E. V. Mikheeva N. P. Pikula 《Pharmaceutical Chemistry Journal》2005,39(3):166-168
Rapid voltammetric procedures for the determination of water-soluble vitamins C, B1, and B2, fat-soluble vitamin E (α-tocopherol acetate), and quercetin in bioactive food additives have been developed. The systematic error (i.e., correctness) of the proposed procedures was evaluated using certified reference materials and the additive recovery tests, which gave the following limiting metrological characteristics: relative error, 25 %; reproducibility, 28 %; convergence, 22 %. The full analysis time (with sample preparation) did not exceed 2 hours. Voltammetric determinations under optimum conditions can be performed in the automated regime controlled by a computer according to the specially developed software.__________Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 3, pp. 54 – 56, March, 2005. 相似文献
887.
888.
889.
V Pesakova P Gillery F X Maquart J P Borel M Adam 《Biomedicine & Pharmacotherapy》1991,45(10):455-459
The effects of some antirheumatics on the formation and retraction of collagen lattices seeded with fibroblasts have been studied. Among the antirheumatics, diclofenac was the most active inhibitor of lattice retraction, then tropesin and to a lesser extent indomethacin. Ibuprofen which is known as a very slight inhibitor of protein synthesis was able to significantly enhance lattice retraction when 10 micrograms/ml (48.5 microM) and 50 micrograms/ml (242 microM) were used. 相似文献
890.
The diagnosis of hysteria is often incorrect and must be made with great caution. A retrospective study demonstrates that an erroneous diagnosis of hysteria is most likely to be given to females, the psychiatrically ill, patients who embellish and patients who present plausible psychogenic explanations for their illness. Movement disorders and paralysis are the neurologic disorders most frequently mislabeled as hysteria. 相似文献