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61.
Elkord E 《Prostate cancer and prostatic diseases》2007,10(3):224-236
Several mechanisms that impair the immune response to promote tumour progression are reported. These mechanisms aim to reduce the ability of antigen-presenting cells to present antigen and activate na?ve T cells to support an active immune response or to create a suppressive environment that induce non-functional tumour-associated antigen-specific T cells. Prostate cancer (PC) alone accounts for 33% of incident cancer cases and about 9% of all cancer-related deaths among men in the USA during 2006. Whereas androgen deprivation has remained the first line of therapy for advanced PC, other therapies are still required due to progression to an androgen-resistant state and eventually loss of control in patients receiving hormonal therapy. Immunotherapy seems to be a promising approach to enhance tumour-specific T-cell responses in different cancers including prostate. More importantly, clinical trials in advanced PC patients have shown that immunotherapy may generate significant clinical responses. Immunology and immunotherapy aspects of PC with focus on prostate-specific antigen will be presented. 相似文献
62.
Eyad Alshammari Shahida Shafi Jaana Nurmi-Lawton Dayangku Fatiha Pengiran Burut Susan Lanham-New Gordon Ferns 《Journal of Sports Science and Medicine》2010,9(4):538-546
High levels of physical activity have been linked to benefits in cardiovascular and bone health by affecting, in part, changes in proinflammatory profile. Therefore, we have aimed to assess the effects of intensive training on markers of inflammation, endothelial activation and auto-immunity in the absence of the potential confounding effects of incident atherosclerosis. The subjects comprised 25 competitive gymnasts and 19 healthy sedentary adolescent females, aged 8-17 years. Serum soluble intercellular adhesion molecule 1 (sICAM-1), high sensitivity C-reactive protein (hsCRP), heat shock protein 27 (Hsp27) and Hsp27 antibody titres were measured by ELISAs in a sample of adolescent girls who were either physically active (competitive gymnasts) or sedentary. The association between age, body mass index (BMI), dietary intake, serum hsCRP, sICAM-1 and Hsp27 antigen and antibody titres were determined. The mean serum sICAM-1 concentrations were significantly higher in the gymnasts compared to the sedentary females (0.29 ± 0.02 versus 0.23 ± 0.01 mg·L-1, p < 0.01). In contrast serum hsCRP concentrations were substantially lower in the gymnasts compared to the sedentary adolescent females (0.49 ± 0.03 versus 1.38 ± 0.19 mg·L-1, p < 0.001). Differences remained significant after adjustment for anthropometric factors. We also found that serum Hsp27 antigen concentrations were determined by dietary saturated fat intake (p < 0.001), and antibody titres to Hsp27 were determined by dietary PUFA (p < 0.001) after adjustment for BMI. Our findings show that young female gymnasts have an altered profile of inflammatory markers and endothelial activation compared to their less physically active peers.
Key points
- Results showed that adolescent young female gymnasts have an altered serum inflammatory markers and endothelial activation, compared to their less physically active peers.
- Physical activities improved immune system.
- Differences in these biochemical data kept significant after adjustment for body weight and height.
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64.
G. Bryan Young Michael D. Sharpe Martin Savard Eyad Al Thenayan Loretta Norton Corrine Davies-Schinkel 《Neurocritical care》2009,11(3):411-416
Introduction
Availability of standard, continuous electroencephalography (cEEG) monitoring in ICU is very limited, although commercially available 4-channel modules are present in many ICUs. We investigated the sensitivity of such modules compared with the more complete monitoring with a standard EEG system. 相似文献65.
66.
Ann Christine Modaragamage Dona Eyad Abuelgasim Biyaser Abuelgasim Muhammed Kermali Syeda Anum Zahra Savini Hewage Amer Harky 《Journal of cardiology》2021,77(4):353-360
Spontaneous coronary artery dissection (SCAD) is a rare but life-threatening disorder. SCAD is gaining importance as an emerging cause of acute coronary syndrome (ACS), especially in otherwise healthy young women. While SCAD and ACS show similarity in presentation, the management of SCAD differs to that of ACS. If not managed properly SCAD can lead to sudden death. This review examines the pathophysiology, clinical presentation, diagnostic algorithms, and the current and future management of SCAD. 相似文献
67.
Naima A. Al‐Mulla MD Prem Chandra PhD Mohammed Khattab MD Faris Madanat MD Parvaneh Vossough MD Eyad Torfa MD Zakiya Al‐Lamki MD Gamal Zain MD Samar Muwakkit MD Salah Mahmoud MD Abdulrahman Al‐Jassmi MD Murat Tuncer MD Hussein Al‐Mukharraq MD Sihem Barsaoui MD Robert J. Arceci MD PhD Scott C. Howard MD Andreas E. Kulozik MD PhD Yaddanapudi Ravindranath MBBS Gregory H. Reaman MD Mohammad Farranoush MD Abdullah A. AlNasser MD 《Pediatric blood & cancer》2014,61(8):1403-1410
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69.
Rana Al-Awadhi Wassim Chehadeh Waleed Al-Jassar Jehad Al-Harmi Eyad Al-Saleh Kusum Kapila 《Archives of virology》2013,158(8):1687-1699
This study was undertaken to evaluate the presence of human papillomavirus (HPV) variants in cervical samples. L1 genetic variable region was studied in 10 HPV types: HPV 11, 16, 18, 33, 53, 54, 56, 61, 66 and 81. A total of 116 isolates were examined, including 47 HPVs isolated from women with normal cytology and 69 with abnormal cytology of different grades. HPV sequences were detected using MY09/MY11 consensus primers. Fifty silent and 65 missense mutations were detected. Two missense mutations were detected in HPV18, 3 in HPV56 and 17 in HPV61. The number of missense mutations per isolate ranged from 1 to 3, except in HPV54 and HPV61, where 7 and 11 missense mutations were found, respectively. Most of the isolates (52.3 %) with missense mutations were isolated from women with abnormal cervical samples. Low-grade squamous intraepithelial lesion cytology diagnosis dominated all cervical abnormalities. This study is the first on the identification of molecular variants in the Middle East and suggests the circulation of new HPV subtypes and variants in Kuwait, which needs to be confirmed by further analysis of the complete HPV genome. 相似文献
70.