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Carles Pericay Anna López Joan Ramón Soler Teresa Bonfill Emma Dotor Eugeni Saigí 《Clinical & translational oncology》2009,11(2):114-116
Oxaliplatin has been classified as an irritant drug. Less than 10 cases of oxaliplatin extravasation through a central venous
access have been described to date. We present a case of extravasation through a central venous access, of the highest dose
(165 mg) of oxaliplatin reported to date. We confirmed the irritant effect, and full recovery from toxicity was achieved.
We describe the treatment administered and offer a review of literature. 相似文献
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Margalida Calafat Triana Lobatón Míriam Mañosa Laura Marín Noemí Caballero Macarena Larraín Eduard Cabré Eugeni Domènech 《Gastroenterologia y hepatologia》2017,40(10):663-668
Background
Ulcerative proctitis (UP) presents distinctive clinical characteristics, outcomes and therapeutic approaches as compared to left-sided and extensive ulcerative colitis (UC).Aim
To describe the current therapeutic requirements and clinical outcomes in patients with active UP.Methods
Retrospective observational study conducted in a referral IBD centre. Patients with UP in follow-up between 1989 and 2014 were included. The clinical characteristics, as well as the different treatments and drug formulations administered to treat flares, were recorded.Results
Out of 687 UC patients, 101 patients (15%) with UP were included. Median follow-up was 8 years (IQR 3–14) and 49% of patients presented disease activity during the study period. Topical mesalazine monotherapy (90%) was the most commonly administered treatment for disease activity (mostly as suppositories), followed by topical steroids (47%) and oral mesalazine (56%) in monotherapy or combination therapy. Only 14% and 16% of patients required oral prednisone and beclomethasone, respectively.Conclusions
In clinical practice, active UP presents mostly favourable outcomes. Mesalazine suppositories are by far the most used treatment for these patients. 相似文献144.
Antonio Agudo Carlos A. González Guillermo Marcos Miguel Sanz Eugeni Saigi Juan Verge Montserrat Boleda Javier Ortego 《Cancer causes & control : CCC》1992,3(2):137-143
A case-control study on gastric cancer was carried out between 1987 and 1989 in four regions of Spain. Three hundred and fifty-four cases of histologically confirmed adenocarcinoma were included (235 men and 119 women). For each case, a control was selected, matched by sex, age, and area of residence, from the same hospital as the case. No association was observed with smoking, nor with the consumption of coffee or tea. The usual consumption of alcohol was associated with gastric cancer in men (odds ratio = 1.54, 95 percent confidence interval = 1.03–2.31), but there was no dose-response relationship. No association was observed in women. All estimations were carried out taking into account the effect of the dietary factors associated with gastric cancer. In accordance with previous evidence, the association observed between gastric cancer and alcohol appears not to be causal.Drs Agudo and González are with the Unit of Epidemiology, Hospital de Mataró, Mataró, Spain. Dr Marcos is with the Department of Preventive Medicine, Hospital Clínico, Zaragoza, Spain. Dr Sanz is with the Department of Pathology, Hospital del INSALUD, Soria, Spain. Dr Saigi is with the Department of Oncology, Hospital General de Granollers, Granollers, Spain. Dr Verge is with the Department of Surgery, Hospital de Terrassa, Terrassa, Spain. Dr Boleda is with the Department of Oncology, Hospital S. Camil, Sant Pere de Riba, Sapin. Dr Ortego is with the Department of Pathology, Hospital Clínico, Zaragoza, Spain. Address correspondence to Dr Agudo, Unit of Epidemiology, Hospital de Mataró, c. Hospital 31, 08301 Mataró, Spain. This study received financial support from the Health Research Fund (FIS) of the Spanish Ministry of Health (Financial Aid for Research exp. 87/1703, exp. 89/0018 and exp. 89/0743) and from the International Agency for Research on Cancer (Collaborative Research Agreement AEP/88/02). 相似文献
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García-Grau E Fusté A Miró A Saldaña C Bados A 《The International journal of eating disorders》2002,32(1):116-120
OBJECTIVE: The main goal of this work was to explore the relationship between coping styles and predisposition to eating disorders in a sample of adolescent girls. METHOD: The sample comprised 186 females (mean age 15.91 years) and the questionnaires used were the Eating Disorders Inventory-2 (EDI-2) and the Adolescent Coping Scale (ACS). RESULTS: The regression analyses indicated that the coping strategy most closely linked to the predisposition to develop an eating disorder was intropunitive avoidance, which explained the following percentage of variance: 29% of the total EDI-2 score, 23% of the personal factor, 28% of the social factor, and 4% of the bodily factor. On the other hand, the scale of intropunitive avoidance dimension with the most explanatory power was the tension reduction, which reflects emotional reactions to problems such as crying, shouting, or taking drugs. DISCUSSION: A cultural hypothesis is presented in an attempt to account for the low percentage of variance of bodily factor explained by intropunitive avoidance and emphasis is placed on the need for prevention programs for adolescents, particularly those at risk. 相似文献
147.
Bego?a Martin-Castillo Eugeni Lopez-Bonet Maria Buxó Joan Dorca Francesc Tuca-Rodríguez Miguel Alonso Ruano Ramon Colomer Javier A. Menendez 《Oncotarget》2015,6(9):7104-7122
There is an urgent need to refine the prognostic taxonomy of HER2+ breast carcinomas and develop easy-to-use, clinic-based prediction algorithms to distinguish between good- and poor-responders to trastuzumab-based therapy. Building on earlier studies suggesting that HER2+ tumors enriched with molecular and morpho-immunohistochemical features classically ascribed to basal-like tumors are highly aggressive and refractory to trastuzumab, we investigated the prognostic and predictive value of the basal-HER2+ phenotype in HER2-overexpressing tumors. Our retrospective cohort study of a consecutive series of 152 HER2+ primary invasive ductal breast carcinomas first confirmed the existence of a distinct subgroup co-expressing HER2 protein and basal cytokeratin markers CK5/6, the so-called basal-HER2+ phenotype. Basal-HER2+ phenotype (≥10% of cells showing positive CK5/6 staining), but not estrogen receptor status, was significantly associated with inferior overall survival by univariate analysis and predicted worsened disease free survival after accounting for strong prognostic variables such as tumor size at diagnosis in stepwise multivariate analysis. In the sub-cohort of HER2+ patients treated with trastuzumab-based adjuvant/neoadjuvant therapy, basal-HER2+ phenotype was found to be the sole independent prognostic marker for a significantly inferior time to treatment failure in multivariate analysis. A CK5/6-based immunohistochemical fingerprint may provide a simple, rapid, and accurate method for re-classifying women diagnosed with HER2+ breast cancer in a manner that can improve prognosis and therapeutic planning in patients with clinically aggressive basal-HER2+ tumors who are not likely to benefit from trastuzumab-based therapy. 相似文献
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Tikunova N Dubrovskaya V Morozova V Yun T Khlusevich Y Bormotov N Laman A Brovko F Shvalov A Belanov E 《Virus research》2012,163(1):141-150
A panel of recombinant human antibodies to orthopoxviruses was isolated from a combinatorial phage display library of human scFv antibodies constructed from the Vh and Vl genes cloned from the peripheral blood lymphocytes of Vaccinia virus (VACV) immune donors. Plaque-reduction neutralization tests showed that seven selected phage-displaying scFv antibodies (pdAbs) neutralized both CPXV and VACV, and five of them neutralized Monkeypox virus (MPXV). Western blot analysis of VACV and CPXV proteins demonstrated that seven neutralizing antibodies recognized a 35 kDa protein. To identify this target protein, we produced a recombinant J3L protein of CPXV and showed that all the selected neutralizing antibodies recognized this protein. Neutralizing pdAb b9 was converted into fully human mAb b9 (fh b9), and scFv b9 displayed high binding affinities (Kd of 0.7 and 3.2 nM). The fh b9 reduced VACV plaque formation in a dose-dependent manner. 相似文献