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51.
González CA Megraud F Buissonniere A Lujan Barroso L Agudo A Duell EJ Boutron-Ruault MC Clavel-Chapelon F Palli D Krogh V Mattiello A Tumino R Sacerdote C Quirós JR Sanchez-Cantalejo E Navarro C Barricarte A Dorronsoro M Khaw KT Wareham N Allen NE Tsilidis KK Bas Bueno-de-Mesquita H Jeurnink SM Numans ME Peeters PH Lagiou P Valanou E Trichopoulou A Kaaks R Lukanova-McGregor A Bergman MM Boeing H Manjer J Lindkvist B Stenling R Hallmans G Mortensen LM Overvad K Olsen A Tjonneland A Bakken K 《Annals of oncology》2012,23(5):1320-1324
BackgroundIn epidemiological studies, Helicobacter pylori infection is usually detected by enzyme-linked immunosorbent assay (ELISA). However, infection can spontaneously clear from the mucosa during the progression of atrophy and could lead to substantial under-detection of infection and underestimation of its effect on gastric cancer (GC) risk. Antibodies detected by western blot are known to persist longer after the loss of the infection.MethodsIn a nested case–control study from the Eurogast-EPIC cohort, including 88 noncardia GC cases and 338 controls, we assessed the association between noncardia GC and H. pylori infection comparing antibodies detected by western blot (HELICOBLOT2.1) to those detected by ELISA (Pyloriset EIA-GIII®).ResultsBy immunoblot, 82 cases (93.2%) were H. pylori positive, 10 of these cases (11.4%) were negative by ELISA and only 6 cases (6.8%) were negative by both ELISA and immunoblot. Multivariable odds ratio (OR) for noncardia GC comparing immunoglobulin G positive versus negative by ELISA was 6.8 [95% confidence interval (CI) 3.0–15.1], and by immunoblot, the OR was 21.4 (95% CI 7.1–64.4).ConclusionsUsing a western blot assay, nearly all noncardia GC were classified as H. pylori positive and the OR was more than threefold higher than the OR assessed by ELISA, supporting the hypothesis that H. pylori infection is a necessary condition for noncardia GC. 相似文献
52.
Crowe FL Key TJ Appleby PN Travis RC Overvad K Jakobsen MU Johnsen NF Tjønneland A Linseisen J Rohrmann S Boeing H Pischon T Trichopoulou A Lagiou P Trichopoulos D Sacerdote C Palli D Tumino R Krogh V Bueno-de-Mesquita HB Kiemeney LA Chirlaque MD Ardanaz E Sánchez MJ Larrañaga N González CA Quirós JR Manjer J Wirfält E Stattin P Hallmans G Khaw KT Bingham S Ferrari P Slimani N Jenab M Riboli E 《The American journal of clinical nutrition》2008,87(5):1405-1413
53.
54.
In a multicenter study, the overall relationship between diet and cancer risk can be broken down into: (a) within-center relationships, which reflect the relationships at the individual level in each of the centers, and (b) a between-center relationship, which captures the association between exposure and disease risk at the aggregate level. In this work, we propose the use of a Bayesian multilevel model that takes into account the within- and between-center levels of evidence, using information at the individual and aggregate level. Correction for measurement error is performed in order to correct for systematic between-center measurement error in dietary exposure, and for attenuation biases in relative risk estimates within centers. The estimation of the parameters is carried out in a Bayesian framework using Gibbs sampling. The model entails a measurement, an exposure, and a disease component. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) the association between lipid intake, assessed through dietary questionnaire and 24-hour dietary recall, and breast cancer incidence was evaluated. This analysis involved 21 534 women and 334 incident breast cancer cases from the EPIC calibration study. In this study, total energy intake was positively associated with breast cancer incidence at the aggregate level, whereas no effect was observed for fat. At the individual level, height was positively related to breast cancer incidence, whereas a weaker association was observed for fat. The use of multilevel models, which constitute a very powerful approach to estimating individual vs aggregate levels of evidence should be considered in multicenter studies. 相似文献
55.
Fatemeh Saberi Hosnijeh Isabelle Romieu Valentina Gallo Elio Riboli Anne Tjønneland Jytte Halkjær Guy Fagherazzi Françoise Clavel-Chapelon Laure Dossus Annie Lukanova Rudolf Kaaks Antonia Trichopoulou Pagona Lagiou Michael Katsoulis Salvatore Panico Giovanna Tagliabue Catalina Bonet Miren Dorronsoro José María Huerta Eva Ardanaz Maria-José Sánchez Dorthe Johansen Signe Borgquist Petra Peeters H. Bas Bueno-de-Mesquita Martine M. Ros Ruth C. Travis Timothy J. Key Paolo Vineis Roel Vermeulen 《Cancer causes & control : CCC》2013,24(3):427-438
Purpose
Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC).Methods
During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia.Results
No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height.Conclusion
The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed. 相似文献56.
Rudolf Kaaks Disorn Sookthai Kari Hemminki Alwin Krmer Heiner Boeing Elisabet Wirflt Elisabete Weiderpass Kim Overvad Anne Tjnneland Anja Olsen Petra H. Peeters H. B Bueno‐de‐Mesquita Salvatore Panico Valeria Pala Paolo Vineis J. Ramn Quirs Eva Ardanaz María‐Jos Snchez Maria‐Dolores Chirlaque Nerea Larraaga Paul Brennan Dimitrios Trichopoulos Antonia Trichopoulou Pagona Lagiou Gran Hallmans Kay‐Tee Khaw Timothy J. Key Elio Riboli Federico Canzian 《International journal of cancer. Journal international du cancer》2014,135(10):2475-2481
Cancer of unknown primary site (CUP) may be called an “orphan” disease, as it is diagnosed when metastases are detected while the primary tumor typically remains undetected, and because little research has been done on its primary causes. So far, few epidemiological studies, if any, have addressed possible risk factors for CUP. We analyzed data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (N = 476,940). During prospective follow‐up, a total of 651 cases of incident cases of CUP were detected (ICD‐O‐2 code C809). Proportional hazards models were conducted to examine the associations of lifetime history of smoking habits, alcohol consumption, levels of education and anthropometric indices of adiposity with risk of being diagnosed with CUP. Risk of being diagnosed with CUP was strongly related to smoking, with a relative risk of 3.66 [95% C.I., 2.24–5.97] for current, heavy smokers (26+ cigarettes/day) compared to never smokers (adjusted for alcohol consumption, body mass index, waist circumference and level of education) and a relative risk of 5.12 [3.09–8.47] for cases with CUP who died within 12 months. For alcohol consumption and level of education, weaker associations were observed but attenuated and no longer statistically significant after adjusting for smoking and indices of obesity. Finally, risk of CUP was increased by approximately 30 per cent for subjects in the highest versus lowest quartiles of waist circumference. Our analyses provide further documentation, in addition to autopsy studies, that a substantial proportion of cancers of unknown primary site may have their origin in smoking‐related tumors, in particular. 相似文献
57.
Suzuki R Allen NE Key TJ Appleby PN Tjønneland A Johnsen NF Jensen MK Overvad K Boeing H Pischon T Kaaks R Rohrmann S Trichopoulou A Misirli G Trichopoulos D Bueno-de-Mesquita HB van Duijnhoven F Sacerdote C Pala V Palli D Tumino R Ardanaz E Quirós JR Larrañaga N Sánchez MJ Tormo MJ Jakszyn P Johansson I Stattin P Berglund G Manjer J Bingham S Khaw KT Egevad L Ferrari P Jenab M Riboli E 《International journal of cancer. Journal international du cancer》2009,124(1):245-249
Few studies have examined the association between dietary fiber intake and prostate cancer risk. We evaluated the association between dietary fiber intake and the risk of prostate cancer among 142,590 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Consumption of dietary fiber (total, cereal, fruit and vegetable fiber) was estimated by validated dietary questionnaires and calibrated using 24-hr dietary recalls. Incidence rate ratios were estimated using Cox regression and adjusted for potential confounding factors. During an average of 8.7 years follow-up, prostate cancer was diagnosed in 2,747 men. Overall, there was no association between dietary fiber intake (total, cereal, fruit or vegetable fiber) and prostate cancer risk, although calibrated intakes of total fiber and fruit fiber were associated with nonstatistically significant reductions in risk. There was no association between fiber derived from cereals or vegetables and risk and no evidence for heterogeneity in any of the risk estimates by stage or grade of disease. Our results suggest that dietary fiber intake is not associated with prostate cancer risk. 相似文献
58.
Reiko Suzuki Naomi E. Allen Paul N. Appleby Timothy J. Key Laure Dossus Anne Tjønneland Nina Føns Johnsen Kim Overvad Carlotta Sacerdote Domenico Palli Vittorio Krogh Rosario Tumino Sabine Rohrmann Jakob Linseisen Heiner Boeing Antonia Trichopoulou Georgios Makrygiannis Gesthimani Misirli H. Bas Bueno-de-Mesquita Anne M. May María José Tormo Díaz Maria-José Sánchez Aurelio Barricarte Gurrea Laudina Rodríguez Suárez Genevieve Buckland Nerea Larrañaga Sheila Bingham Kay-Tee Khaw Sabina Rinaldi Nadia Slimani Mazda Jenab Elio Riboli Rudolf Kaaks 《Cancer causes & control : CCC》2009,20(6):811-821
Objective To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy
men.
Methods We conducted a cross-sectional analysis of the association of lifestyle factors with circulating concentrations of androstenedione
(A-dione), 3-α-androstanediol glucuronide (A-diol-g), testosterone (T), SHBG (sex hormone-binding globulin), and free testosterone
(FT) among 636 men in the European Prospective Investigation into Cancer and Nutrition.
Results Compared with the youngest age group (40–49 years), the oldest (70–79 years) had a higher mean concentration of SHBG (by 44%)
and lower mean concentrations of A-diol-g (by 29%) FT (19%). Men in the highest BMI group (≥29.83 kg/m2) had a higher mean A-diol-g concentration (by 38%) and lower mean concentration of T (by 20%) SHBG (29%) compared with the
lowest (<24.16 kg/m2). Current smokers had higher mean concentrations of T (by 13%), SHBG (14%), and A-dione (15%) compared with never smokers.
Physical activity and dietary factors were not associated with androgen concentrations, although men in the highest fifth
of alcohol intake had higher mean concentrations of A-dione (by 9%), FT (11%) compared with the lowest.
Conclusion Our results suggest that age, body weight, smoking, and alcohol intake are associated with circulating androgen concentrations
in men. 相似文献
59.
Breast Prostate Cancer Cohort Consortium Cox DG Bretsky P Kraft P Pharoah P Albanes D Altshuler D Amiano P Berglund G Boeing H Buring J Burtt N Calle EE Canzian F Chanock S Clavel-Chapelon F Colditz GA Feigelson HS Haiman CA Hankinson SE Hirschhorn J Henderson BE Hoover R Hunter DJ Kaaks R Kolonel L LeMarchand L Lund E Palli D Peeters PH Pike MC Riboli E Stram DO Thun M Tjonneland A Travis RC Trichopoulos D Yeager M 《International journal of cancer. Journal international du cancer》2008,122(2):387-392
Exposure to exogenous (oral contraceptives, postmenopausal hormone therapy) and endogenous (number of ovulatory cycles, adiposity) steroid hormones is associated with breast cancer risk. Breast cancer risk associated with these exposures could hypothetically be modified by genes in the steroid hormone synthesis, metabolism and signaling pathways. Estrogen receptors are the first step along the path of signaling cell growth and development upon stimulation with estrogens. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium has systematically selected haplotype tagging SNPs in genes along the steroid hormone synthesis, metabolism and binding pathways, including the estrogen receptor beta (ESR2) gene. Four htSNPs tag the 6 major (>5% frequency) haplotypes of the ESR2 gene. These polymorphisms have been genotyped in 5,789 breast cancer cases and 7,761 controls nested within the American Cancer Society Cancer Prevention Study II, European Prospective Investigation into Cancer and Nutrition, Multiethnic Cohort, Nurses' Health Study and Women's Health Study cohorts. None of the SNPs were independently associated with breast cancer risk. One haplotype of the ESR2 gene was associated with breast cancer risk before correction for multiple testing (OR 1.17, 95% CI 1.07-1.28, p = 0.0007). This haplotype remained associated with breast cancer risk after adjustment for multiple testing using a permutation procedure. There was no statistically significant heterogeneity in SNP or haplotype odds ratios across cohorts. These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women. 相似文献
60.
Mireia Obón-Santacana Leila Luján-Barroso Heinz Freisling Sabine Naudin Marie-Christine Boutron-Ruault Francesca Romana Mancini Vinciane Rebours Tilman Kühn Verena Katzke Heiner Boeing Anne Tjønneland Anja Olsen Kim Overvad Cristina Lasheras Miguel Rodríguez-Barranco Pilar Amiano Carmen Santiuste Eva Ardanaz Kay-Thee Khaw Nicholas J. Wareham Julie A. Schmidt Dagfinn Aune Antonia Trichopoulou Paschalis Thriskos Eleni Peppa Giovanna Masala Sara Grioni Rosario Tumino Salvatore Panico Bas Bueno-de-Mesquita Veronica Sciannameo Roel Vermeulen Emily Sonestedt Malin Sund Elisabete Weiderpass Guri Skeie Carlos A. González Elio Riboli Eric J. Duell 《International journal of cancer. Journal international du cancer》2020,146(1):76-84
Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk. 相似文献