全文获取类型
收费全文 | 1347篇 |
免费 | 71篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 66篇 |
妇产科学 | 8篇 |
基础医学 | 156篇 |
口腔科学 | 62篇 |
临床医学 | 103篇 |
内科学 | 256篇 |
皮肤病学 | 12篇 |
神经病学 | 188篇 |
特种医学 | 27篇 |
外科学 | 104篇 |
综合类 | 2篇 |
预防医学 | 126篇 |
眼科学 | 4篇 |
药学 | 41篇 |
中国医学 | 1篇 |
肿瘤学 | 248篇 |
出版年
2023年 | 11篇 |
2022年 | 23篇 |
2021年 | 40篇 |
2020年 | 29篇 |
2019年 | 32篇 |
2018年 | 44篇 |
2017年 | 31篇 |
2016年 | 32篇 |
2015年 | 32篇 |
2014年 | 39篇 |
2013年 | 47篇 |
2012年 | 98篇 |
2011年 | 106篇 |
2010年 | 46篇 |
2009年 | 51篇 |
2008年 | 68篇 |
2007年 | 75篇 |
2006年 | 80篇 |
2005年 | 85篇 |
2004年 | 73篇 |
2003年 | 64篇 |
2002年 | 64篇 |
2001年 | 27篇 |
2000年 | 15篇 |
1999年 | 15篇 |
1998年 | 23篇 |
1997年 | 9篇 |
1996年 | 9篇 |
1995年 | 10篇 |
1994年 | 11篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 17篇 |
1990年 | 8篇 |
1989年 | 9篇 |
1988年 | 9篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 3篇 |
1980年 | 7篇 |
1979年 | 7篇 |
1978年 | 3篇 |
1976年 | 4篇 |
1968年 | 3篇 |
1967年 | 3篇 |
1938年 | 2篇 |
排序方式: 共有1429条查询结果,搜索用时 240 毫秒
41.
Laura Villarreal‐Martínez Jaime García‐Chvez Berenice Snchez‐Jara Aida Mashenka Moreno‐Gonzlez Janet Soto‐Padilla Efraín Aquino‐Fernndez Rogelio Paredes‐Aguilera Karla Maldonado‐Silva Cecilia Rodríguez‐Castillejos Ana Itamar Gonzlez‐vila María Mora‐Torres Hector Manuel Tiznado‐García Natalia Elizabeth Padilla‐Durn Nuria Citlali Luna‐Silva Eric Israel Gutirrez‐Jurez Jorge Nemi‐Cueto Claudia Sofia Gmez‐Gonzlez Ricardo De Len‐Figueroa Adela Lpez‐Miranda Mirna Guadalupe Ríos‐Osuna Edna Liliana Tamez‐Gmez Elio Aarn Reyes‐Espinoza Irving Armando Domínguez‐Varela Gerardo Gonzlez‐Martínez Elias Adn Godoy‐Salinas 《Haemophilia》2020,26(2):290-297
42.
43.
44.
45.
46.
47.
Paolo Della Pina Enrico Vizzardi Riccardo Raddino Mara Gavazzoni Giorgio Caretta Elio Gorga Livio Dei Cas 《Cardiovascular toxicology》2012,12(4):285-297
The last 20 years was characterized by great improvements in the efficacy and tolerability of anticancer therapies. Most of these changes are related to the introduction of targeted drugs, which presents a better activity on the biology of cancer and less toxicity. Nevertheless, the initial enthusiasm was cooled by the emerging evidences of cardiac side effects. The aim of this review is to describe the actual knowledge about the possible cardiotoxicity of targeted drugs. The most important need is the detection of early cardiotoxicity and the evidence of subtle myocardial dysfunction that allows to begin a protective therapy. In our review we analyzed the non invasive imaging techniques to early predict myocardial dysfunction. Echocardiography seems to be the ideal method for her availability, safety and clinical usefulness, in particular the new echocardiographic techniques like speckle tracking. 相似文献
48.
49.
Damiano Pasqualini Loredana Bergandi Luigi Palumbo Alberto Borraccino Valentina Dambra Mario Alovisi Giuseppe Migliaretti Gaetana Ferraro Dario Ghigo Serena Bergerone Nicola Scotti Mario Aimetti Elio Berutti 《Journal of endodontics》2012
Introduction
There is evidence to suggest that an association exists between oral infections and coronary heart disease (CHD). Subjects presenting lesions of endodontic origin (LEOs) or pulpal inflammation had an increased risk of developing CHD. However, findings concerning systemic manifestations of apical periodontitis (AP) remain controversial. An association between CD14 gene polymorphisms and atherosclerosis-associated diseases has been shown, but there are no data regarding an association between CD14 polymorphism and AP. This study evaluated associations between clinical oral health status, CD14 polymorphisms, and CHD.Methods
A case-controlled clinical trial was designed to compare middle-aged adults with acute myocardial infarction or unstable angina (n = 51) within 12 months of the acute event defined as first manifestation with healthy controls (n = 49). Participants were matched for age, sex, and socioeconomic status. Indicators of oral disease and compliance were evaluated. CD14 polymorphisms were analyzed by restriction fragment length polymorphism–polymerase chain reaction.Results
CHD subjects had a higher prevalence of oral diseases and lower compliance to oral preventive strategies than healthy controls. Multivariate analysis showed a positive association between missing teeth (odds ratio [OR] = 1.37; 95% confidence interval [CI], 1.02–1.85), the number of LEOs (OR = 4.37; 95% CI, 1.69–11.28), chronic periodontitis (OR = 5.87; 95% CI, 1.17–29.4), and CHD. No statistically significant association emerged between the CD14 C(−260)T and the CD14 C(−159)T polymorphism, endodontic or periodontal disease, and CHD.Conclusions
Chronic oral diseases may increase the risk of CHD and may be an unconventional risk factor for CHD. 相似文献50.
Scalabrini D Fenoglio C Scarpini E De Riz M Comi C Venturelli E Cortini F Piola M Villa C Naldi P Monaco F Bresolin N Galimberti D 《Neuroscience letters》2007,425(3):173-176
Recently, proteomic analysis in cerebrospinal fluid (CSF) from patients with MS identified four proteins which are present in MS but not in normal human CSF, including SPARCL1, an extracellular matrix-associated protein member of the SPARC family. One hundred eighty-six patients with MS and 185 age-matched controls were genotyped for A/G single nucleotide polymorphism (SNP) in exon 1 (rs1049539), C/G SNP in exon 4 (rs1049544), resulting in a substitution of an aspartate with an histidine, and A/G substitution in the exon 5 (rs1130643), leading to the substitution of alanine with threonine. No significant differences in either allelic or genotypic frequency of the three SNPs were found (P>0.05), even in stratifying MS patients according to the course of the disease. Stratifying according to gender, a trend towards a decreased frequency of the C/C genotype of the rs1049544 was observed in male patients as compared with male controls (30.2% versus 44.0%; P=0.217). Despite proteomic studies in CSF from MS patients suggested an important role for SPARCL1 in the development of the disease, SPARCL1 gene does not appear to act as susceptibility factor for MS in the population investigated here. However, the frequency of the C/C genotype of rs1049544 was decreased in male patients, possibly conferring a lower risk of developing MS in male population. Further studies are needed to clarify this issue. 相似文献