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71.
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Tam LS Li EK Leung VY Griffith JF Benzie IF Lim PL Whitney B Lee VW Lee KK Thomas GN Tomlinson B 《The Journal of rheumatology》2005,32(2):275-282
OBJECTIVE: Patients with systemic lupus erythematosus (SLE) experience excess morbidity and mortality due to coronary artery disease (CAD) that cannot be fully explained by the classical CAD risk factors. Among emerging CAD risk factors, oxidative stress is currently being emphasized. We evaluated the effects of longterm antioxidant vitamins on markers of oxidative stress and antioxidant defense and endothelial function in 39 patients with SLE. METHODS: Patients were randomized to receive either placebo or vitamins (500 mg vitamin C and 800 IU vitamin E daily) for 12 weeks. Markers of oxidative stress included malondialdehyde (MDA) and allantoin. Antioxidants measured included erythrocyte superoxide dismutase and glutathione peroxidase, plasma total antioxidant power (as FRAP value), and ascorbic acid and vitamin E concentrations. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery and plasma concentration of von Willebrand factor (vWF) and plasminogen activator inhibitor type 1 (PAI-1). Primary outcome of the study included the change in lipid peroxidation as revealed by MDA levels. Secondary outcomes included changes in allantoin and antioxidant levels and change in endothelial function. RESULTS: After treatment, plasma ascorbic acid and alpha-tocopherol concentrations were significantly (p < 0.05) increased only in the vitamin-treated group, associated with a significant decrease (p < 0.05) in plasma MDA. Other oxidative stress markers and antioxidant levels remained unchanged in both groups. FMD and vWF and PAI-1 levels remained unchanged in both groups. CONCLUSION: Combined administration of vitamins C and E was associated with decreased lipid peroxidation, but did not affect endothelial function in patients with SLE after 3 months of therapy. 相似文献
73.
Effects of high-intensity exercise on leptin and testosterone concentrations in well-trained males 总被引:2,自引:0,他引:2
Kraemer RR Durand RJ Acevedo EO Johnson LG Synovitz LB Kraemer GR Gimpel T Castracane VD 《Endocrine》2003,21(3):261-265
Objective: A number of investigations have examined the effect of exercise on leptin concentrations, because leptin is associated
with obesity, satiety, and reproductive function. High-intensity exercise is known to increase testosterone, an inhibitor
of leptin. The objective of the study was to determine whether the leptin responses to a progressive, intermittent exercise
protocol were related to serum testosterone concentrations. Most previous studies have examined leptin responses to low or
moderately high exercise intensities. A second objective was to determine whether leptin responses were different than previous
experiments using intermittent moderate and high-intensity exercise.
Methods: Well-trained runners completed strenuous intermittent exercise consisting of treadmill running at 60, 75, 90, and
100% VO
2max and a subsequent resting control trial was also conducted.
Results: There were significant increases in mean serum levels of leptin and testosterone with both quickly returning to baseline
during recovery, but no relationship between the two hormones was found. After examining individual data for both hormones,
it was discovered that subjects could be classified as leptin responders or nonresponders, whereas testosterone increased
in all subjects. Responders had elevated serum leptin levels at baseline and exhibited increases after high-intensity exercise,
whereas nonresponders did not show changes in leptin during exercise.
Conclusions: Data suggest testosterone levels do not acutely affect leptin responses to exercise or 1-h of recovery. Moreover,
varied leptin responses to intense exercise in comparable well-trained runners was observed and was associated with baseline
leptin concentrations. 相似文献
74.
Simone Steinhausen Oliver Ommen Sonja Thüm Rolf Lefering Thorsten Koehler Edmund Neugebauer Holger Pfaff 《Patient education and counseling》2014
Objective
To analyze whether patients’ perception of their medical treatment outcome is higher among patients who experienced a higher empathy by trauma surgeons during their stay in hospital.Methods
127 patients were surveyed six weeks after discharge from the trauma surgical general ward. Subjective evaluation of medical treatment outcome was measured with the corresponding scale from the Cologne Patient Questionnaire. Clinical empathy was assessed by using the CARE measure. The influence of physician empathy and control variables on a dichotomized index of subjective evaluation of medical treatment outcome was identified with a logistic regression.Results
120 patients were included in the logistic regression analysis. Compared to patients with physician empathy ratings of less than 30 points, patients with ratings of 41 points or higher have a 20-fold higher probability to be in the group with a better medical treatment outcome on the CPQ-scale (α-level < .001, R2 46.9).Conclusion
Findings emphasize the importance of a well-functioning relationship between physician and patient even in a surgical setting where the focus is mostly on the bare medical treatment.Practice implications
Communication trainings i.e. in surgical education can be an effective way to improve the ability to show empathy with patients’ concerns. 相似文献75.
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Aaron M. Samuels Elizabeth Matey Pauline N. M. Mwinzi Ryan E. Wiegand Geoffrey Muchiri Edmund Ireri Molly Hyde Susan P. Montgomery Diana M. S. Karanja W. Evan Secor 《The American journal of tropical medicine and hygiene》2012,87(5):874-882
Schistosomiasis control programs aim to reduce morbidity but are evaluated by infection prevalence and intensity reduction. We present baseline cross-sectional data from a nested cohort study comparing indicators of morbidity for measuring program impact. Eight hundred twenty-two schoolchildren 7–8 years of age from Nyanza Province, Kenya, contributed stool for diagnosis of Schistosoma mansoni and soil-transmitted helminths (STH) and blood smears for malaria, and were evaluated for anemia, quality of life, exercise tolerance, anthropometry, and ultrasound abnormalities. Schistosoma mansoni, STH, and malaria infection prevalence were 69%, 25%, and 8%, respectively. Only anemia and S. mansoni infection (adjusted odds ratio [aOR] = 1.70; confidence interval [CI] = 1.03–2.80), and hepatomegaly and heavy S. mansoni infection (aOR = 2.21; CI = 1.19–4.11) were associated. Though anemia and hepatomegaly appeared most useful at baseline, additional morbidity indicators may be sensitive longitudinal measures to evaluate schistosomiasis program health impact. 相似文献
78.
Lu Y Giver CR Sharma A Li JM Darlak KA Owens LM Roback JD Galipeau J Waller EK 《Blood》2012,119(4):1075-1085
Allogeneic hematopoietic stem cell transplantation (HSCT) can eradicate chemorefractory leukemia through the graft-versus-leukemia (GVL) activity of donor T cells. However, the clinical success of allo-HSCT is limited by the graft-versus-host disease (GVHD) activity of donor T cells. We have reported previously that donor bone marrow precursors of plasmacytoid dendritic cells (pre-pDCs) can activate donor T cells toward T-helper 1 immune polarization in murine allogeneic HSCT. To optimize the GVL activity of these activated donor T cells and limit their graft versus host activity, we engineered the cellular constituents of an allogeneic hematopoietic stem cell graft with highly purified hematopoietic stem cells, T cells, and pre-pDCs and studied their GVL and GVHD activities in a murine model of allogeneic HSCT. Transplanted donor pre-pDCs expanded in vivo for 2 weeks after transplant, and they markedly augmented the activation and GVL activity of donor T cells while attenuating their GVHD activity, leading to an improved therapeutic index. Bidirectional signaling between donor T cells and donor pDCs with IFN-γ synthesis by donor T cells inducing indoleamine 2,3-dioxygenase synthesis by donor pDCs limited GVHD by altering the balance between donor T-reg and inflammatory T cells. Manipulating the content of donor DC precursors in allogeneic HSCT is a novel method to optimize the balance between GVL and GVHD. 相似文献
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