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251.
Intracranial tumours are an excellent target for photodiagnosis (PD), fluorescence guided resection (FGR) and photodynamic therapy (PDT), because the tumour to brain ratio of photosensitizers’ concentration is very high. However, several attempts of proving the value of PDT in the most malignant type of brain tumours, gliobastoma multeforme (GBM) failed to demonstrate any significant worthwhile survival advantage in the past because of the very nature of this cancer and several compounding factors that led to this apparent disappointing outcome; variations in the photosensitizer and light dosages, variations in the photosensitizer administration to treatment time-intervals, and variations in photosensitizers used are just few to mention in this article. However, after a very long gestation period of brain PD, FGR and PDT, three randomized controlled trials (RCT) in brain PD, FGR and PDT were concluded by 2007. The first trial demonstrated that time to tumour progression (TTP) was significantly longer in patients who had PD and FGR compared to standard surgical resection but this difference did not translate into survival advantage in GBM due to the variability in the management of recurrent tumours and significant residual tumour cells left after FGR in about a third of patients leading to GBM relapse. The second trial compared single shot PDT in GBM and standard therapy. Neither the treatment nor the control group received PD or FGR. Again this RCT did not provide any survival advantage in patients who had had PDT due to the fact that standard surgical resection had left significant residual tumour in a large number of patients canceling any potential benefit from PDT. The last trial compared combined PD, FGR and repetitive PDT and standard therapy and confirmed that TTP was significantly longer in the treatment group and demonstrated that the treatment group had significant survival advantage in GBM. In conclusion, PD, FGR and PDT need to be combined to be effective in brain tumours and in the future, we will see more and more scientific evidence accumulating in support of brain PD, FGR and PDT. The next decade will see further refinement and evolution of the techniques and technology employed and expansion of the indications of brain PD, FGR and PDT. 相似文献
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Casanueva FF Molitch ME Schlechte JA Abs R Bonert V Bronstein MD Brue T Cappabianca P Colao A Fahlbusch R Fideleff H Hadani M Kelly P Kleinberg D Laws ED Marek J Scanlon M Sobrinho LG Wass JAH Giustina A 吴哲褒 张亚卓 《中华神经外科杂志》2008,24(12)
治疗的目的是PRL水平正常.然而,许多学者认为,最好是降低PRL水平到可能的最低值,因为这一策略能最大可能地缩小肿瘤体积甚至于肿瘤消失.为了避免不能耐受药物和药物不良反应,从低剂量开始治疗,并逐步加量.肿瘤缩小后假使PRL水平保持在正常范围,则可以慢慢减少DA剂量. 相似文献
254.
Michael D Spencer T J William Moorhead Rod J Gibson Andrew M McIntosh Jessika ED Sussmann David GC Owens Stephen M Lawrie Eve C Johnstone 《BMC medicine》2008,6(1):1
Background
Although neuroanatomical and cognitive sequelae of low birthweight and preterm birth have been investigated, little is understood as to the likely prevalence of a history of low birthweight or preterm birth, or neuroanatomical correlates of such a history, within the special educational needs population. Our aim was to address these issues in a sample of young people receiving additional learning support. 相似文献255.
MA Braga O Tarzia CC Bergamaschi FA Santos ED Andrade FC Groppo 《International journal of dental hygiene》2009,7(2):126-130
Abstract: Objective: The aim of the present study was to compare the effect of low‐dose pilocarpine and cevimeline as stimulants for salivary flow in healthy subjects. Methods: In this cross‐over clinical trial with a 1‐week washout period, 40 male volunteers were submitted to an oral dose of pilocarpine 1% (Salagen?) ?60 μg kg?1 body‐weight (Group 1) or Cevimeline (Evoxac?) ?30 mg (Group 2). Saliva samples were collected and the salivary flow rate was measured (ml min?1) at baseline and 20, 40, 60, 80, 140 and 200 min after administration of drugs. In addition, salivary secretion was also measured under mechanical stimulation to observe salivary gland function. Results: The data were analyzed by Friedman and Wilcoxon signed‐rank tests (significance level = 5%). Pilocarpine and cevimeline significantly increased salivary flow 140 min after intake. There was a significant higher secretion with cevimeline 140 and 200 min after administration. There were no differences seen among subjects in the salivary glands function by mechanical stimulation. Conclusion: Both drugs showed efficacy in increasing the salivary flow in healthy volunteers, but cevimeline was more effective than pilocarpine. 相似文献
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Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies 总被引:4,自引:0,他引:4
Nemunaitis J; Singer JW; Buckner CD; Hill R; Storb R; Thomas ED; Appelbaum FR 《Blood》1988,72(2):834-836
The use of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) following autologous marrow transplantation for lymphoid malignancies was explored in a phase I/II dose escalation study. rhGM-CSF given as a 2-hour infusion daily for 14 days was well tolerated at doses up to 240 micrograms/m2/day. When compared with 86 disease-matched and treatment-matched historical controls, patients receiving greater than or equal to 60 micrograms/m2/day rhGM-CSF recovered neutrophil and platelet counts more rapidly, had fewer days with fever, and were discharged from the hospital sooner. 相似文献
260.