子宫内膜异位症癌抗原(CA125)检测及其临床意义

目的：探讨子宫内膜异位症与ＣＡ１２５有无相关性、提高临床子宫内膜异位症诊断雍诊断最佳途径。方法：用放射免疫测定法（ＲＩＡ）检测７９例子宫内膜异位症、７０例子宫肌瘤、６４例子宫颈癌、８０名正常育龄女性为对照。结果：子宫内膜异位症、子宫肌瘤、子宫颈癌、正常对照组阳性率分别是７９．７５％、８．５７％、１７．１９％、０．００％。前者显著高于后三者（Ｐ〈０．０１）。结论：ＣＡ１２５检测为临床诊断子宫内膜异位     

子宫内膜癌组织学类型与CEA、c-erbB-2表达

目的：观察子宫内膜癌的组织学类型与ＣＥＡ、ｃ－ｅｒｂＢ－２表达,探讨其组织学发生。方法：光镜观察组织学形态并进行分型,应用免疫组化Ｓ－Ｐ法,对９４例子宫内膜癌进行单克隆抗体ＣＥＡ和ｃ－ｅｒｂＢ－２检测。结果：子宫内膜样癌６１例（６４．８％）,腺棘癌６例（６．３％）,腺鳞癌８例（８．４％）,浆液性乳头状腺癌７例（７．４％）,粘液性癌５例（５．３％）,小细胞癌４例（４．２％）,透明细胞癌和鳞癌各１例（     

人流术中应用异丙酚与复合应用氯胺酮的比较

本实验旨在探讨微量氯胺酮与异丙酚联合应用的效果,以期获得更安全、更适合门诊手术的麻醉方式。　　作者简介:郭晓丽(1963-),女,河南省新乡市人,硕士研究生,主治医师,讲师,主要从事麻醉镇痛方面的研究,发表论文5篇。电话:(023)68757347　　收稿日期:20000508;修回日期:200010201　资料与方法　　研究对象:60例停经8～12周的早期妊娠妇女,年龄17～43岁,体重40～77ｋｇ,ＡＳＡⅠ～Ⅱ级,术前禁食6ｈ,禁饮4ｈ。麻醉前20ｍｉｎ肌注阿托品0.5ｍｇ。随机分为两组,异丙酚+氯胺酮组(ＰＫ组,ｎ=30例);异丙酚组(Ｐ组,ｎ=30例麻醉方法:ＰＫ组:异丙酚1～…     

Amino acid and carnitine supplementation in haemodialysed children

Plasma carnitine, amino acids and lipids levels were studied in ten uraemic children treated with haemodialysis and given amino acid supplementation with and without carnitine. As carnitine is synthesised from lysine and methionine and has a significant influence on lipid metabolism, the relationship between these was examined. Amino acid supplementation (0.25 g/kg body weight) was started with the intention of improving the plasma amino acid pattern in these children and increasing the concentration of lysine, which is the substrate for carnitine synthesis. Amino acids were administered i. v. during dialysis and carnitine (25 mg/kg body weight i. v.) was administered after dialysis three times a week. Concentrations of most essential amino acids were decreased in these patients. The first period of amino acid supplementation did not increase plasma levels of the essential amino acids, with the exception of tyrosine (P<0.01). After the second period of supplementation, methionine was increased (P<0.01), isoleucine was decreased (P<0.01), but tyrosine normalised and was significantly lower than after the first period (P<0.05). Thus overall amino acid supplementation did not improve amino acid levels; it was inconsistently associated with a further decrease in highdensity lipoprotein-cholesterol and an increase in total protein levels. Lysine concentrations after amino acid supplementation remained low. Paradoxically, before carnitine supplementation a positive correlation between free carnitine and triglycerides was observed. The plasma carnitine concentration, initially very low, was excessively high after carnitine supplementation. After carnitine administration no amelioration of any of the other biochemical indices was observed. Carnitine supplementation was associated with a significant reduction of total protein levels (P<0.01). In children with end-stage renal disease on haemodialysis, neither amino acid nor carnitine supplementation appear to result in significant improvements in plasma levels of essential amino acids or lipids.     

一种用电容式传感器检测呼吸度的方法

目的介绍一种操作简单而成本低廉的呼吸率检测方法。方法 采用高灵敏度电容传感器,以及相应的检测系统,可以对呼吸活动进行检测。结果在一般左胸上部大部分位置均能得到较为满意的信号。结论应用前景广泛,可用于构成多参数监护仪中的呼吸模块,亦可用来检测呼吸波。     

3-Hydroxydicarboxylic aciduria due to long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency associated with sudden neonatal death: protective effect of medium-chain triglyceride treatment

Two siblings were found to be affected by longchain 3-hydroxyacyl-CoA dehydrogenase deficiency, one of which died suddenly and unexpectedly on the 3rd day of life suffering from extreme hypoketotic hypoglycaemia. The younger sibling started to have feeding problems, lowered consciousness, and liver dysfunction at the age of 5 months. Her urine contained large amounts of C₆–C₁₄ 3-hydroxydicarboxylic acids and conjugated 3-hydroxyoctanoic acid, as verified by gas chromatography/mass spectrometry. Plasma long-chain acylcarnitine was increased. A clue to the diagnosis was given by the results of a phenylpropionic acid loading test. This revealed small, but significant amounts of conjugated 3-hydroxyphenylpropionic acid (phenylhydracrylic acid) in the patient's urine. Subsequently, the activity of long-chain 3-hydroxyacyl-CoA dehydrogenase was found to be deficient in cultured skin fibroblasts. Based on the findings obtained by a medium-chain triglyceride load, a diet enriched in this type of fat was prescribed. On this regimen the patient started to thrive, signs of cardiomyopathy disappeared, and her liver function normalized.