Severity evaluation of obstructive sleep apnea based on speech features

Sleep and Breathing - There are upper airway abnormalities in patients with obstructive sleep apnea (OSA), and their speech signal characteristics are different from those of unaffected people. In...     

Levels of trace blood elements associated with severe sleep disturbance in maintenance hemodialysis patients

Sleep and Breathing - Sleep disturbance is frequently observed in patients on maintenance hemodialysis (MHD), and this population usually presents imbalances in trace elements. We...     

基于IDEAL-IQ序列精准定量腹部脂肪体积技术的临床应用

目的研究基于IDEAL-IQ序列脂肪分量图精准定量腹部脂肪体积的临床应用价值。 方法回顾性收集2018年5月至2020年9月深圳市宝安区中心医院行IDEAL-IQ序列检查82例患者的腰围、体重,序列所得脂肪分量像利用AW4.6后处理工作站Reformat功能处理,半自动提取患者L2、L3椎体水平内脏脂肪及皮下脂肪,二者相加得出相应层面腹部脂肪体积。 结果82例患者年龄(40.4±10.9)岁,体重(74.9±9.5)kg,腰围(92.9±8.9)cm。L2椎体水平内脏脂肪体积(555.33±177.38)cm³、皮下脂肪体积(497.59±207.53)cm³、腹部脂肪体积(1052.91±305.81)cm³。L3椎体水平内脏脂肪体积(552.50±184.39)cm³、皮下脂肪体积(564.01±213.65)cm³、腹部脂肪体积(1086.51±330.24)cm³。L2、L3椎体水平腹部脂肪体积与体重中等相关(r＝0.629,0.671,P<0.01)。L2、L3椎体水平腹部脂肪体积与腰围相关性较高(r＝0.771,0.805,P<0.01)。 结论IDEAL-IQ序列快捷、准确、无创、安全,辅以后处理功能,提供了一种半自动精准定量体内脂肪含量的技术,有望替代传统CT扫描成为临床对于体内脂肪含量及分布更佳的观察、随访方式。     

Hydrogen evolution from silicon nanowire surfaces

This paper presents the study on the hydrogen evolution reaction (HER) of the silicon nanowire (SiNW)-based surfaces. Large-area SiNWs with different lengths were fabricated on the silicon surfaces by a cost effective and scalable wet-etching method. The SiNW-based surfaces promoted the photoelectrocatalytical performance of the electrodes due to the increased effective surface area for electrolyte diffusion and the fast release of hydrogen bubbles that formed on the electrodes. In addition, at different applied potentials, the nanostructured electrodes showed different behaviour that depended on the SiNWs'' with different lengths and morphologies. For example, surfaces with longer SiNWs performed better in the low potential region, while surfaces with shorter SiNWs presented improved performance in the high potential region. The findings in this study provide new insights into designing electrodes with desired nanostructures for improved HER performance.

This paper presents the study on the hydrogen evolution reaction (HER) of the silicon nanowire (SiNW)-based surfaces.     

基于快速康复在先心病伴气道异常患儿的护理及评价

目的：通过基于快速康复理念建立先心病伴气道异常的围术期护理措施,并进行效果评价。方法：选择2015年1月-12月符合要求41名患儿作为对照组;选择2017年1月-10月符合要求的43名患儿应用快速康复护理作为实验组分别进行干预和数据收集。结果：实验组中呼吸机再插管,重返ICU显著低于对照组（P<0.05）;实验组患儿的住院时间,ICU滞留时间以及呼吸机使用时间均较对照组患儿缩短（P<0.05）。结论：本次研究证实基于多学科合作的快速康复模式是安全可行的,能够减少患儿ICU 住院时间,降低医疗费用,有良好的社会和经济效益。     

Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility

Multiple studies have shown that phospholamban (PLN) plays a key role in regulation of frequency-dependent increase of cardiac contraction, a hallmark of the contractile reserve in myocardium. However, the mechanisms underlying this relationship remain elusive. Phosphorylation of PLN occurs on residues: serine-16 (Ser(16)) and threonine-17 (Thr(17)) in vivo. In isolated wild-type cardiomyocytes, we found that increases of stimulation frequency from 0.5 to 5 Hz were associated with increased Thr(17) phosphorylation of PLN and cardiac contractility. To further delineate the role of PLN phosphorylation in the frequency-dependent increases of cardiac function, three transgenic mouse models, expressing wild-type, Ser16Ala (S16A), or Thr17Ala (T17A) mutant PLN in the null background were generated. Transgenic lines expressing similar levels of wild-type or mutant PLN were selected and isolated cardiomyocytes were paced from 0.5 to 5 Hz. Upon increases in pacing frequency, the fractional shortening (FS) and rates of contraction (+dL/dt) and relaxation (-dL/dt) increased in wild-type and S16A mutant PLN cardiomyocytes. In contrast, in myocytes expressing the T17A mutant PLN, there were no increases in FS and +/-dL/dt upon increasing the frequency of stimulation. The time to 50% peak shortening (TTP(50)) and to 50% relaxation (TTR(50)) were also abbreviated to a much higher extent (two-fold) in wild-type and S16A mutant compared to T17A mutant PLN cardiomyocytes. These results indicate that Thr(17) phosphorylation of PLN is the major contributor to frequency-dependent increases of contractile and relaxation parameters in mouse cardiomyocytes, although some increases in these parameters occur even in the absence of PLN phosphorylation. Thus, the positive force-frequency relationship in cardiomyocytes is mechanistically and mainly related to PLN phosphorylation.