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41.
Schizophrenia, an illness and a metaphor: analysis of the use of the term 'schizophrenia' in the UK national newspapers
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OBJECTIVE: To determine whether schizophrenia is a commonly used 'illness as metaphor', to compare the use of schizophrenia and cancer as illnesses as metaphor, and to determine if there is a difference in such usage between the UK and USA. DESIGN: An examination of articles published in the British press. SETTING: 600 articles from six British newspapers: the Times, the Daily Telegraph, the Guardian, the Mirror, the Sun and the Daily Mail. MAIN OUTCOME MEASURES: Use of schizophrenia and cancer as metaphors. RESULTS: Schizophrenia was more likely to be metaphorized than cancer (P<0.001) in the UK press, but was less likely to be used as metaphor in the UK press than in the US press (P<0.001). 11% of articles containing the term schizophrenia used the word as a metaphor. CONCLUSIONS: Clinicians need to be aware that patients, carers and the public might have a different understanding of the word we use as a diagnosis. 相似文献
42.
Pearce AC Wilde JI Doody GM Best D Inoue O Vigorito E Tybulewicz VL Turner M Watson SP 《Blood》2002,100(10):3561-3569
We have investigated the role of the Rho and Rac family small guanine triphosphate (GTP) exchange factors (RhoGEFs), Vav1 and Vav2, in the activation of platelets by the immunoreceptor tyrosine-based activation motif (ITAM)-coupled collagen receptor GPVI and by the G protein-coupled receptor agonist thrombin. The glycoprotein VI (GPVI)-specific agonist collagen-related peptide (CRP) and thrombin stimulated tyrosine phosphorylation of Vav1 but not Vav2 in human platelets. Surprisingly, however, CRP did not activate the low-molecular-weight G protein Rac and stimulated only a small increase in activity of p21-associated kinase 2 (PAK2), despite the fact that both proteins are regulated downstream of Vav1 in other cells. Further, activation of Rac and PAK2 by thrombin was maintained in platelets from mice deficient in Vav1. Activation of phospholipase C (PLC) by GPVI and thrombin was unaltered in Vav1-, Vav2-, and Vav1/Vav2-deficient platelets. A weak inhibition of late-stage aggregation to CRP and thrombin was observed in platelets deficient in Vav1 but not Vav2, whereas spreading on fibrinogen was not changed. The present results demonstrate that neither Vav1 nor Vav2 lie upstream of PLC or Rac in platelets, highlighting an important difference in their role in signaling by ITAM-coupled receptors in other cell types. The present study has provided evidence for a possible role of Vav1 but not Vav2 in the later stages of platelet aggregation. 相似文献
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Natasja A. M. Kragten Gina M. Doody Nicholas A. Barnes Ester B. M. Remmerswaal Cheng‐Chih Hsiao Perry D. Moerland Diana Wouters Ingrid A. M. Derks Amber van Stijn Marc Demkes Jörg Hamann Eric Eldering Martijn A. Nolte Reuben M. Tooze Ineke J. M. ten Berge René A. W. van Lier 《European journal of immunology》2015,45(10):2945-2958
46.
Luke Barbara Brown Morton B. Wantman Ethan Forestieri Nina E. Browne Marilyn L. Fisher Sarah C. Yazdy Mahsa M. Ethen Mary K. Canfield Mark A. Nichols Hazel B. Oehninger Sergio Doody Kevin J. Sutcliffe Alastair G. Williams Carrie Eisenberg Michael L. Baker Valerie L. Sacha Caitlin R. Lupo Philip J. 《Journal of assisted reproduction and genetics》2021,38(4):835-846
Journal of Assisted Reproduction and Genetics - Excess embryos transferred (ET) (> plurality at birth) and fetal heartbeats (FHB) at 6 weeks’ gestation are associated with reductions... 相似文献
47.
K J Doody M C Lorence J I Mason E R Simpson 《The Journal of clinical endocrinology and metabolism》1990,70(4):1041-1045
The levels of expression of mRNA species encoding cholesterol side-chain cleavage cytochrome P-450 (P450scc), 17 alpha-hydroxylase cytochrome P450 (P450(17 alpha], aromatase cytochrome P-450 (P-450AROM), and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) were examined in human follicles and corpora lutea (CL) throughout the menstrual cycle. Tissues were obtained from women undergoing hysterectomy and oophorectomy. The largest follicle or the CL was dissected from the ovary depending on whether the surgery was performed in the follicular or luteal phase. The day of the cycle was determined by onset of last menstrual period and was confirmed by endometrial histology. Total RNA was examined by Northern blot analysis, using as probes specific 32P-labeled cDNA inserts encoding each human enzyme. Early follicles demonstrated detectable mRNA for both P450scc and P450(17 alpha), but not for P450AROM or 3 beta HSD. P450AROM was detectable late in the follicular phase and appeared markedly induced in the CL. 3 beta HSD was detectable only in the CL. Levels of P450(17 alpha) mRNA remained relatively unchanged throughout the cycle, whereas P450scc mRNA levels were greatly increased in the CL. The presence of P450(17 alpha) mRNA in the human CL is of interest, since it is absent from the bovine CL, and this is consistent with the ability of the human, but not the bovine, CL to synthesize 17 alpha-hydroxyprogesterone and estrogens. The fact that P450AROM expression is highest in CL is surprising, since plasma estrogen levels are highest during the late follicular phase of the cycle, and may suggest that CL estrogen biosynthesis is limited by 17 alpha-hydroxylase or 17,20-lyase activities. 相似文献
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D P Ryan D D Muehrcke D P Doody S H Kim P K Donahoe 《Journal of pediatric surgery》1991,26(8):962-9; discussion 969-70
Since the first successful repair of a complete laryngotracheoesophageal cleft (LTEC) to the carina in 1982, three newborn infants were observed with a particularly difficult variant in which the cleft extends beyond the carina into the mainstem bronchi. This type IV LTEC creates a long common tracheoesophagus, whose successful separation requires meticulous preoperative, operative, and postsurgical care. Three infants had complete surgical repair at our institution at 29, 49, and 225 days old and survived a minimum of 8 months. Recurrent tracheoesophageal fistulae at the thoracic inlet occurred in two infants, but was not observed in one patient when sternocleidomastoid muscle was interposed between the trachea and esophagus in the neck. Microgastria is an associated finding in each infant with the tracheoesophageal cleft extending beyond the carina. The small stomach is problematic as it is anatomically inadequate for any antireflux procedure and has not grown well, even with prolonged feeding. Early cleft repair is essential to prevent the development of chronic lung disease secondary to recurrent aspiration. The techniques to make the diagnosis, the preferred treatment to initially protect the airway, a single-stage operation performed simultaneously through the chest and neck to definitively repair the cleft, and finally the intraoperative and postoperative management critical for an optimal outcome are described. 相似文献
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