全文获取类型
收费全文 | 55324篇 |
免费 | 5164篇 |
国内免费 | 3496篇 |
专业分类
耳鼻咽喉 | 539篇 |
儿科学 | 662篇 |
妇产科学 | 459篇 |
基础医学 | 6454篇 |
口腔科学 | 852篇 |
临床医学 | 6673篇 |
内科学 | 8980篇 |
皮肤病学 | 686篇 |
神经病学 | 3099篇 |
特种医学 | 2523篇 |
外国民族医学 | 19篇 |
外科学 | 5833篇 |
综合类 | 8880篇 |
现状与发展 | 14篇 |
一般理论 | 7篇 |
预防医学 | 3513篇 |
眼科学 | 1365篇 |
药学 | 5862篇 |
51篇 | |
中国医学 | 2838篇 |
肿瘤学 | 4675篇 |
出版年
2024年 | 153篇 |
2023年 | 768篇 |
2022年 | 1973篇 |
2021年 | 2683篇 |
2020年 | 1992篇 |
2019年 | 1769篇 |
2018年 | 1845篇 |
2017年 | 1701篇 |
2016年 | 1826篇 |
2015年 | 2640篇 |
2014年 | 3149篇 |
2013年 | 3118篇 |
2012年 | 4450篇 |
2011年 | 4743篇 |
2010年 | 3415篇 |
2009年 | 2623篇 |
2008年 | 3179篇 |
2007年 | 3159篇 |
2006年 | 2859篇 |
2005年 | 2805篇 |
2004年 | 2041篇 |
2003年 | 2127篇 |
2002年 | 1793篇 |
2001年 | 1312篇 |
2000年 | 1018篇 |
1999年 | 966篇 |
1998年 | 574篇 |
1997年 | 562篇 |
1996年 | 373篇 |
1995年 | 435篇 |
1994年 | 308篇 |
1993年 | 188篇 |
1992年 | 274篇 |
1991年 | 196篇 |
1990年 | 166篇 |
1989年 | 172篇 |
1988年 | 116篇 |
1987年 | 123篇 |
1986年 | 119篇 |
1985年 | 61篇 |
1984年 | 40篇 |
1983年 | 21篇 |
1982年 | 25篇 |
1981年 | 16篇 |
1980年 | 15篇 |
1979年 | 15篇 |
1974年 | 8篇 |
1973年 | 13篇 |
1972年 | 9篇 |
1969年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
11.
Background:Gastrointestinal complications and malnutrition are common problems that affect postoperative rehabilitation and survival of patients with esophageal cancer. Evidence has shown that probiotics have a positive effect on improving gastrointestinal complications and nutritional status of patients with esophageal cancer after surgery, but there is a lack of prospective studies on this topic. We designed this prospective randomized controlled trial to evaluate the effects of probiotics on gastrointestinal complications and nutritional status in patients with postoperative esophageal cancer.Methods:This is a prospective, randomized, double-blind, placebo-controlled trial. It was approved by the Clinical Research Ethics Committee of our hospital. 192 patients will be randomly divided into probiotics group and the placebo group in a 1:1 ratio. After operation, probiotics and placebo will be given orally for 8 weeks. The indexes of nutritional status and incidence of digestive tract complications will be recorded and the data will be analyzed by SPSS 18.0 software.Discussion:This study will evaluate the effect of probiotics on gastrointestinal complications and nutritional status of postoperative patients with esophageal cancer. The results of this study will provide clinical basis for the use of probiotics in postoperative treatment of esophageal cancer.Trial registration:OSF Registration number: D DOI 10.17605/OSF.IO/QHW86 相似文献
12.
患者女,40岁,因"咳嗽10个月余,咳绿色浓痰伴发热5 d"就诊本院。体格检查:神志清,一般情况可。2018年10月26日外院胸部CT平扫及增强(图1)示右肺上叶肺门旁直径约2.2 cm类圆形结节影,边缘光整,无毛刺及卫星灶,密度尚均匀;增强后明显强化,动脉期CT值约107 HU,静脉期CT值约89 HU,考虑为硬化性肺细胞瘤。于外院行抗炎、止咳、化痰等治疗,症状无缓解。 相似文献
13.
舌癌患者手术及放化疗后会出现构音障碍、吞咽困难、口腔黏膜炎、口干、营养不良等并发症,使患者生存质量下降,甚至导致肿瘤的复发转移,影响生存期,单一方法往往顾此失彼。依托于中国中医科学院西苑医院肿瘤康复基地,杨宇飞教授在国内外调研考察基础上,结合中国国情,构建了一种“门诊多学科肿瘤康复模式”,在舌癌康复方面,以患者为中心,以中医肿瘤内科为主导,多学科共同参与,结合康复科、口腔科、营养科、药剂科等各科优势,形成全程个体化规范序贯康复方案,对患者及早进行康复,在放疗前进行预防性干预尤其重要,使患者能够快速缓解手术和放疗的不良反应,患者获益明显。现取两个典型案例总结其舌癌多学科康复的经验,以期为舌癌的康复提供借鉴。 相似文献
14.
15.
No national epidemiological investigations have been conducted recently regarding facial lacerations. The study was performed using the data of 3,634,229 people during the 5-year period from 2014 to 2018 archived by the National Health Information Database (NHID) of the Health Insurance Review and Assessment Service. Preschool and children under 10 years old accounted for about one-third of patients. Facial lacerations were concentrated in the “T-shaped” area, which comprised forehead, nose, lips, and the perioral area. The male to female ratio for all study subjects was 2.16:1. Age and gender are significantly related with each other (P < .001). Mean hospital stays decreased, and numbers of outpatient department visits per patient were highest for hospitals and lowest for health agencies. Over the study period, hospital costs per patient in tertiary and general hospitals increased gradually. Preschool and school-aged children are vulnerable to trauma. Male patients outnumbered female patients by a factor of more than 2. The “T-shaped’” area around forehead is vulnerable to injury. Total cost of medical care benefits per patient in tertiary hospitals was about 7 times on average than in health agencies. Regarding functional, behavioral, and aesthetic outcomes, more attention should be paid to epidemiologic data and hospital costs for facial lacerations. 相似文献
16.
Discoid lupus erythematosus (DLE) is the most common skin manifestation of lupus; however, the molecular mechanisms underlying DLE remain unknown. Therefore, we aimed to identify key differentially expressed genes (DEGs) in discoid lupus skin and investigate their potential pathways.To identify candidate genes involved in the occurrence and development of the disease, we downloaded the microarray datasets and GSE52471 from the Gene Expression Database (GEO). DEGs between discoid lupus skin and normal controls were selected using the GEO2R tool and Venn diagram software ( GSE72535http://bioinformatics.psb.ugent.be/webtools/Venn/). The Database for Annotation, Visualization, and Integrated Discovery (DAVID), Enrichr, and Cytoscape ClueGo were used to analyze the Kyoto Encyclopedia of Gene and Genome pathways and gene ontology. Protein-protein interactions (PPIs) of these DEGs were further assessed using the Search Tool for the Retrieval Interacting Genes version 10.0.Seventy three DEGs were co-expressed in both datasets. DEGs were predominantly upregulated in receptor signaling pathways of the immune response. In the PPI network, 69 upregulated genes were selected. Furthermore, 4 genes (CXCL10, ISG15, IFIH1, and IRF7) were found to be significantly upregulated in the RIG-I-like receptor signaling pathway, from analysis of Enrichr and Cytoscape ClueGo.The results of this study may provide new insights into the potential molecular mechanisms of DLE. However, further experimentation is required to confirm these findings. 相似文献
17.
18.
Jae Hwang Song Chan Kang Deuk Soo Hwang Dong Hun Kang Yong Hwan Kim 《Foot and Ankle Surgery》2019,25(6):748-754
BackgroundThe purpose of this study was to investigate and compare the clinical outcomes of dorsal suspension with those of neurectomy for the treatment of Morton’s neuroma.MethodsWe conducted a retrospective study of dorsal suspension and neurectomy group. The dorsal suspension was performed by dorsal transposition of neuroma over the dorsal transverse ligament after neurolysis. The visual analog scale (VAS), the Foot and Ankle Ability Measure (FAAM), postoperative satisfaction, and complications were evaluated.ResultsBoth groups reported significant pain relief, and there were no significant differences between the groups with respect to postoperative pain. The postoperative FAAM outcomes showed no significant between-group differences. Satisfaction analysis showed ‘excellent’ and ‘good’ results in the dorsal suspension and neurectomy groups (95% and 77.7%, respectively). Complications of numbness and paresthesia reported in the dorsal suspension group (5% and 5%, respectively) were significantly fewer than those of neurectomy group (61.1% and 33.3%, respectively) (both, p < .05).ConclusionsWith its favorable results, dorsal suspension can be another operative option for the treatment of Morton’s neuroma.Level of Evidence: Level III, retrospective comparative case series. 相似文献
19.
20.
Parallel enzyme‐linked immunosorbent assay screening for human immunodeficiency virus among blood donors in five Chinese blood centres: a retrospective analysis 下载免费PDF全文