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排序方式: 共有7962条查询结果,搜索用时 218 毫秒
971.
972.
Giuseppe Giordano Luigi Fanzone Diego Meo Sebastiano Piana Viviana Lentini Savino Borracino Enrico Potenza Vincenzo Magnano San Lio 《Radiology Case Reports》2021,16(9):2437
We report the case of a woman with a mass in the anterior and middle mediastinum (a non-small-cell lung carcinoma), determining significant compression of both superior vena cava and right pulmonary artery. The patient developed acute respiratory distress syndrome , necessitating intubation and admission to the Intensive Care Unit . Radiotherapy sessions to reduce the mass effect were attempted, without significant clinical improvement. Due to the persistence of severe hypoxemia, stenting of the superior vena cava and the right pulmonary artery was performed, the latter resulting in a significant improvement of the arterial blood gas parameters, allowing extubation of the patient. In our opinion, stenting of the superior vena cava and the pulmonary artery (or its branches) is an effective and safe treatment; it should be considered in similar cases, especially if other - less invasive - treatments fail. 相似文献
973.
Giuseppe Ermondi Diego Garcia Jimenez Matteo Rossi Sebastiano Giulia Caron 《ACS medicinal chemistry letters》2021,12(7):1056
To obtain new oral drugs in the beyond rule of five space, PROTACs among others, molecular properties should be optimized in early drug discovery. Degraders call for design strategies which focus on intramolecular interaction and chameleonicity. In parallel, tailored revalidation of permeability assessment and prediction methods becomes fundamental in this innovative chemical space. 相似文献
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975.
Miki Yokokawa Rakesh Latchamsetty Hamid Ghanbari Diego Belardi Akash Makkar Brett Roberts Wouter Saint-Phard Mohamad Sinno Thomas Carrigan Robert Kennedy Arisara Suwanagool Eric Good Thomas Crawford Krit Jongnarangsin Frank Pelosi Frank Bogun Hakan Oral Fred Morady Aman Chugh 《Heart rhythm》2013,10(4):469-476
976.
Romilda Cardin Marika Piciocchi Diego Martines Laura Scribano Marino Petracco Fabio Farinati 《Digestive and liver disease》2013,45(6):499-504
BackgroundCoffee is associated with a reduced risk of hepatocellular carcinoma in patients with chronic C hepatitis. This prospective trial was aimed at assessing the mechanisms underlying coffee-related protective effects.MethodsForty patients with chronic hepatitis C were randomized into two groups: the first consumed 4 cups of coffee/day for 30 days, while the second remained coffee “abstinent”. At day 30, the groups were switched over for a second month.ResultsAt baseline, aspartate aminotransferase and alanine aminotransferase were lower in patients drinking 3–5 (Group B) than 0–2 cups/day (Group A) (56 ± 6 vs 74 ± 11/60 ± 3 vs 73 ± 7 U/L p = 0.05/p = 0.04, respectively). HCV-RNA levels were significantly higher in Group B [(6.2 ± 1.5) × 105 vs (3.9 ± 1.0) × 105 UI/mL, p = 0.05]. During coffee intake, 8-hydroxydeoxyguanosine and collagen levels were significantly lower than during abstinence (15 ± 3 vs 44 ± 16 8-hydroxydeoxyguanosine/105 deoxyguanosine, p = 0.05 and 56 ± 9 vs 86 ± 21 ng/mL, p = 0.04). Telomere length was significantly higher in patients during coffee intake (0.68 ± 0.06 vs 0.48 ± 0.04 Arbitrary Units, p = 0.006). Telomere length and 8-hydroxydeoxyguanosine were inversely correlated.ConclusionIn chronic hepatitis C coffee consumption induces a reduction in oxidative damage, correlated with increased telomere length and apoptosis, with lower collagen synthesis, factors that probably mediate the protection exerted by coffee with respect to disease progression. 相似文献
977.
Ernesto Tartaglia Stefano Reggio Diego Cuccurullo Massimiliano Fabozzi Carlo Sagnelli Lucia Miranda 《Minimally invasive therapy & allied technologies》2013,22(5):298-303
AbstractBackground: Near-total splenectomy (NTS) represents an innovative and effective surgery technique for spleen disease, reducing the risk of severe infections and thromboembolic events after total splenectomy. The authors reported a laparoscopic near-total splenectomy (LNTS) surgical experience following the optimal results of the open approach, describing a standardized and effective minimally invasive technique with the purpose of preserving a minimal residual spleen.Material and methods: From November 2006 to September 2016, 15 patients with splenic and hematologic disease underwent LNTS, according to a laparoscopic procedure developed by the authors. The end criterion was to conserve a remanent spleen of 10–15?cm3 in size.Results: Patient age ranged between 18 and 59 years. Mean operative time was 70?±?20?min. Mean hospital stay was 3.46 (range 3–7) days. One complication occurred during the surgery for a lesion of the inferior polar artery with need of a total splenectomy. No conversion to open surgery was necessary.Conclusions: LNTS is a safe and effective technique for the management of splenic and hematologic disease with a low intra- and post-operative complication rate, and it can minimize the late sequelae of secondary splenectomy. However, it requires further studies with more cases to evaluate its role. 相似文献
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979.
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Darjus Felix Tschaharganeh Xin Chen Philipp Latzko Mona Malz Matthias Martin Gaida Klaus Felix Sara Ladu Stephan Singer Federico Pinna Norbert Gretz Carsten Sticht Maria Lauda Tomasi Salvatore Delogu Matthias Evert Biao Fan Silvia Ribback Lijie Jiang Stefania Brozzetti Frank Bergmann Frank Dombrowski Peter Schirmacher Diego Francesco Calvisi Kai Breuhahn 《Gastroenterology》2013