全文获取类型
收费全文 | 518篇 |
免费 | 16篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 8篇 |
妇产科学 | 8篇 |
基础医学 | 54篇 |
口腔科学 | 2篇 |
临床医学 | 72篇 |
内科学 | 126篇 |
皮肤病学 | 11篇 |
神经病学 | 94篇 |
特种医学 | 18篇 |
外科学 | 91篇 |
综合类 | 3篇 |
预防医学 | 33篇 |
药学 | 14篇 |
肿瘤学 | 14篇 |
出版年
2023年 | 5篇 |
2022年 | 7篇 |
2021年 | 25篇 |
2020年 | 11篇 |
2019年 | 9篇 |
2018年 | 18篇 |
2017年 | 14篇 |
2016年 | 14篇 |
2015年 | 17篇 |
2014年 | 27篇 |
2013年 | 28篇 |
2012年 | 44篇 |
2011年 | 45篇 |
2010年 | 25篇 |
2009年 | 31篇 |
2008年 | 40篇 |
2007年 | 41篇 |
2006年 | 39篇 |
2005年 | 17篇 |
2004年 | 23篇 |
2003年 | 22篇 |
2002年 | 28篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1994年 | 1篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1983年 | 1篇 |
排序方式: 共有549条查询结果,搜索用时 375 毫秒
11.
Edna H. G. Venneker Willem J. Remme MD PhD Diederik C. A. van Hoogenhuyze X. Hanno Krauss G. Louis Bartels Dick A. C. M. Kruijssen Cock J. Storm Dick van Schelven 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》1994,8(2):211-219
Summary Antiischemic effects of 1-blocking agents are based on intrinsic negative inotropic and chronotropic properties. Partial 1-agonistic activity, although useful in preserving cardiac function, may counteract such antischemic properties by modulating the intrinsic negative cardiac effects of beta-blockade. To investigate the acute hemodynamic and antiischemic profile of epanolol, a cardioselective 1-antagonist and partial agonist, 20 patients with left coronary artery disease underwent two incremental atrial pacing tests, 45 minutes before (APST I) and 15 minutes after (APST II) 4 mg intravenous epanolol, administered over 5 minutes. Additional measurements were carried out at 1, 3, 5, 10, and 15 minutes after epanolol, at basal and fixed heart rates. Epanolol immediately reduced heart rate with a maximum of 10% at 15 minutes and decreased contractility (Vmax) by 7% (both p<.05), whereas cardiac output fell temporarily by 9% (p<.05). Other hemodynamic parameters did not change, except for a significant 11% reduction in myocardial oxygen demand. Despite comparable pacing conditions, both the double product and contractility decreased significantly less during APST II, resulting in a 17% lower myocardial oxygen consumption (p<.05). Myocardial ischemia was markedly reduced, indicated by normalization of lactate metabolism [lactate extraction 16±7% vs. –7±8% (APST I)], less ST depression (21%), and modulation of LV end-diastolic pressure postpacing (all p<.05 vs. APST I), whereas angina was absent or less in 14 patients. None of the patients reported an adverse effect. Thus, under resting conditions intravenous epanolol induces moderate, short-lasting negative chronotropic and inotropic effects, but does not alter cardiac pump function or vascular resistance, reflecting its additional 1-agonistic properties. Alternatively, during pacing it still reduces ischemia through negative inotropic effects and diminishes myocardial oxygen demand, reflecting its 1-antagonistic profile. 相似文献
12.
Eikendal Anouk L.M. de Lorijn Fleur Heisterkamp Sabien G.J. de Kruiff Chris C. Bosman Diederik K. 《Tijdschrift voor kindergeneeskunde》2013,81(1):39-39
Tijdschrift voor Kindergeneeskunde - 相似文献
13.
14.
K. Molloy C. Jonak F.J.S.H. Woei-A-Jin E. Guenova A.M. Busschots A. Bervoets E. Hauben R. Knobler S. Porkert C. Fassnacht R. Cowan E. Papadavid M. Beylot-Barry E. Berti S. Alberti Violetti T. Estrach R. Matin O. Akilov L. Vakeva M. Prince A. Bates M. Bayne R. Wachsmuch U. Wehkamp M. Marschalko O. Servitje D. Turner S. Weatherhead M. Wobser J.A. Sanches P. McKay D. Klemke C. Peng A. Howles J. Yoo F. Evison J. Scarisbrick 《The British journal of dermatology》2020,182(3):770-779
15.
Rio P. Juni Rushd Al-Shama Diederik W.D. Kuster Jolanda van der Velden Henrike M. Hamer Marc G. Vervloet Etto C. Eringa Pieter Koolwijk Victor W.M. van Hinsbergh 《Kidney international》2021,99(5):1088-1101
- Download : Download high-res image (468KB)
- Download : Download full-size image
16.
17.
We analyze different aspects of our quantum modeling approach of human concepts and, more specifically, focus on the quantum effects of contextuality, interference, entanglement, and emergence, illustrating how each of them makes its appearance in specific situations of the dynamics of human concepts and their combinations. We point out the relation of our approach, which is based on an ontology of a concept as an entity in a state changing under influence of a context, with the main traditional concept theories, that is, prototype theory, exemplar theory, and theory theory. We ponder about the question why quantum theory performs so well in its modeling of human concepts, and we shed light on this question by analyzing the role of complex amplitudes, showing how they allow to describe interference in the statistics of measurement outcomes, while in the traditional theories statistics of outcomes originates in classical probability weights, without the possibility of interference. The relevance of complex numbers, the appearance of entanglement, and the role of Fock space in explaining contextual emergence, all as unique features of the quantum modeling, are explicitly revealed in this article by analyzing human concepts and their dynamics. 相似文献
18.
19.
20.