全文获取类型
收费全文 | 692篇 |
免费 | 83篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 16篇 |
妇产科学 | 18篇 |
基础医学 | 140篇 |
口腔科学 | 27篇 |
临床医学 | 75篇 |
内科学 | 167篇 |
皮肤病学 | 3篇 |
神经病学 | 53篇 |
特种医学 | 11篇 |
外科学 | 91篇 |
综合类 | 27篇 |
预防医学 | 107篇 |
眼科学 | 7篇 |
药学 | 17篇 |
中国医学 | 2篇 |
肿瘤学 | 20篇 |
出版年
2022年 | 10篇 |
2021年 | 13篇 |
2020年 | 7篇 |
2019年 | 15篇 |
2018年 | 15篇 |
2017年 | 9篇 |
2016年 | 16篇 |
2015年 | 7篇 |
2014年 | 16篇 |
2013年 | 25篇 |
2012年 | 43篇 |
2011年 | 37篇 |
2010年 | 23篇 |
2009年 | 21篇 |
2008年 | 41篇 |
2007年 | 44篇 |
2006年 | 25篇 |
2005年 | 30篇 |
2004年 | 28篇 |
2003年 | 21篇 |
2002年 | 21篇 |
2001年 | 16篇 |
2000年 | 24篇 |
1999年 | 12篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 7篇 |
1992年 | 15篇 |
1991年 | 12篇 |
1990年 | 13篇 |
1989年 | 10篇 |
1988年 | 15篇 |
1987年 | 7篇 |
1986年 | 8篇 |
1985年 | 9篇 |
1984年 | 9篇 |
1981年 | 6篇 |
1979年 | 5篇 |
1977年 | 4篇 |
1975年 | 12篇 |
1974年 | 14篇 |
1973年 | 14篇 |
1972年 | 9篇 |
1971年 | 9篇 |
1970年 | 4篇 |
1969年 | 4篇 |
1968年 | 5篇 |
1967年 | 7篇 |
1966年 | 4篇 |
1961年 | 5篇 |
排序方式: 共有784条查询结果,搜索用时 31 毫秒
21.
Priyathama Vellanki Rachel Bean Festus A. Oyedokun Francisco J. Pasquel Dawn Smiley Farnoosh Farrokhi Christopher Newton Limin Peng Guillermo E. Umpierrez 《Diabetes care》2015,38(4):568-574
OBJECTIVE
Clinical guidelines recommend point-of-care glucose testing and the use of supplemental doses of rapid-acting insulin before meals and at bedtime for correction of hyperglycemia. The efficacy and safety of this recommendation, however, have not been tested in the hospital setting.RESEARCH DESIGN AND METHODS
In this open-label, randomized controlled trial, 206 general medicine and surgery patients with type 2 diabetes treated with a basal-bolus regimen were randomized to receive either supplemental insulin (n = 106) at bedtime for blood glucose (BG) >7.8 mmol/L or no supplemental insulin (n = 100) except for BG >19.4 mmol/L. Point-of-care testing was performed before meals, at bedtime, and at 3:00 a.m. The primary outcome was the difference in fasting BG. In addition to the intention-to-treat analysis, an as-treated analysis was performed where the primary outcome was analyzed for only the bedtime BG levels between 7.8 and 19.4 mmol/L.RESULTS
There were no differences in mean fasting BG for the intention-to-treat (8.8 ± 2.4 vs. 8.6 ± 2.2 mmol/L, P = 0.76) and as-treated (8.9 ± 2.4 vs. 8.8 ± 2.4 mmol/L, P = 0.92) analyses. Only 66% of patients in the supplement and 8% in the no supplement groups received bedtime supplemental insulin. Hypoglycemia (BG <3.9 mmol/L) did not differ between groups for either the intention-to-treat (30% vs. 26%, P = 0.50) or the as-treated (4% vs. 8%, P = 0.37) analysis.CONCLUSIONS
The use of insulin supplements for correction of bedtime hyperglycemia was not associated with an improvement in glycemic control. We conclude that routine use of bedtime insulin supplementation is not indicated for management of inpatients with type 2 diabetes. 相似文献22.
23.
24.
25.
Alexithymia,Coping Styles and Traumatic Stress Symptoms in a Sample of Veterans Who Experienced Military Sexual Trauma
下载免费PDF全文
![点击此处可从《Stress and health》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The current study examined the association between alexithymia and coping styles (planning, positive reinterpretation and growth, social‐emotion coping, and denial), and trauma symptoms in a clinical sample of 170 male and female veterans who experienced sexual trauma during military service. Denial was the only coping style positively associated with trauma symptoms, and it mediated the relationship between alexithymia and trauma symptoms. Alexithymia was negatively associated with planning. Likewise, alexithymia was negatively associated with social‐emotional coping and with positive reinterpretation and growth. The results speak to the significant role that alexithymia has in predicting individual coping styles. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
26.
Ndiaye M Hane AA Ndir M Ba O Cissokho S Diop-Dia D Kandji M Ndiaye S Diatta A Toure NO Niang A Dia Y Sow ML 《Revue de pneumologie clinique》2000,56(6):355-360
National immunization and control programs have not brought about a significant decline in tuberculosis, which remains a real public health concern in our regions. Prevention in the working environment should be part of an overall prevention program for the general population. Nevertheless, companies should play a leading role because they have the necessary structure and assets. We analyzed the epidemiology of tuberculosis in the working environment using demographic data on employees in Senegal, current medicolegal data on tuberculosis in Senegal and data on prevention of tuberculosis. Our analysis led to a proposed strategy for controlling tuberculosis spread and its prevention in the working environment in Senegal. 相似文献
27.
Sequences of the Escherichia coli dnaG primase gene and regulation of its expression. 总被引:21,自引:5,他引:21
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
B L Smiley J R Lupski P S Svec R McMacken G N Godson 《Proceedings of the National Academy of Sciences of the United States of America》1982,79(15):4550-4554
The nucleotide sequence of a cloned section of the Escherichia coli chromosome containing the dnaG primase gene [Lupski, J., Smiley, B., Blattner, F. & Godson, G. N. (1982) Mol. Gen, Genet. 185, 120--128] has been determined. The region coding for the dnaG primase has been identified by NH2-terminal and tryptic peptide amino acid analysis of the dnaG protein. The coding region is 1,740 base pairs long (580 amino acids) and is preceded by an unusual ribosome-binding site sequence (G-G-G-G). The dnaG gene is read in the same direction as the adjacent rpoD gene, but no obvious promoter sequences can be found for either gene within several hundred nucleotides upstream. Other unusual features of the dnaG gene that may explain the maintenance of its product at low copy number are the presence of a RNA polymerase terminator 31 nucleotides upstream from the ATG initiator codon and greater use (3--10 times) of certain condons that occur infrequently in other E. coli genes. The nucleotide sequence has also been correlated with data from transposon Tn5 insertional inactivation mapping. 相似文献
28.
Dia Sanou Erin O’Reilly Ismael Ngnie-Teta Malek Batal Nathalie Mondain Caroline Andrew Bruce K. Newbold Ivy L. Bourgeault 《Journal of immigrant and minority health / Center for Minority Public Health》2014,16(1):24-34
Although recent immigrants to Canada are healthier than Canadian born (i.e., the Healthy Immigrant Effect), they experience a deterioration in their health status which is partly due to transitions in dietary habits. Since pathways to these transitions are under-documented, this scoping review aims to identify knowledge gaps and research priorities related to immigrant nutritional health. A total of 49 articles were retrieved and reviewed using electronic databases and a stakeholder consultation was undertaken to consolidate findings. Overall, research tends to confirm the Healthy Immigrant Effect and suggests that significant knowledge gaps in nutritional health persist, thereby creating a barrier to the advancement of health promotion and the achievement of maximum health equity. Five research priorities were identified including (1) risks and benefits associated with traditional/ethnic foods; (2) access and outreach to immigrants; (3) mechanisms and coping strategies for food security; (4) mechanisms of food choice in immigrant families; and (5) health promotion strategies that work for immigrant populations. 相似文献
29.
30.
Patricia A. Smiley Lindsey C. Partington Caroline R. Cochran Jessica L. Borelli 《Developmental psychobiology》2020,62(8):1134-1149
Parental socialization that infringes on children's autonomy may have consequences for physiological regulation, trait anxiety, and state distress. One such practice is the use of positive conditional regard (CR)—the provision of extra attention/affection when children meet parents’ expectations. Self-determination theory proposes that CR thwarts satisfaction of children's basic needs for relatedness and autonomy by placing these needs in conflict. We evaluate associations among children's (N = 106, 51% male, Mage = 10.27 years, SD = 1.09) reports of their mothers’ use of positive CR to suppress anger expression (PCR-anger), their physiological regulation (resting respiratory sinus arrhythmia, RSA), and their trait anxiety and state distress, in light of perceived relationship closeness. After controlling demographics, mothers’ reports of positive and negative CR-anger, children's reports of mothers’ negative CR-anger and depressive symptoms, greater child-reported positive CR-anger was significantly associated with greater child anxiety and with lower resting RSA. Resting RSA mediated associations of child-reported positive CR-anger with greater child anxiety and post-failure distress. These indirect effects were significant for children low or moderate in closeness to mother. We conclude that autonomy-restrictive socialization is a concurrent correlate of children's physiological regulation, anxiety, and state distress, with these associations dependent on relational distance. 相似文献