全文获取类型
收费全文 | 277481篇 |
免费 | 18973篇 |
国内免费 | 1169篇 |
专业分类
耳鼻咽喉 | 3166篇 |
儿科学 | 7575篇 |
妇产科学 | 5055篇 |
基础医学 | 35913篇 |
口腔科学 | 5063篇 |
临床医学 | 26934篇 |
内科学 | 60321篇 |
皮肤病学 | 4242篇 |
神经病学 | 26443篇 |
特种医学 | 9143篇 |
外国民族医学 | 11篇 |
外科学 | 42254篇 |
综合类 | 3562篇 |
一般理论 | 320篇 |
预防医学 | 23622篇 |
眼科学 | 7009篇 |
药学 | 18293篇 |
6篇 | |
中国医学 | 454篇 |
肿瘤学 | 18237篇 |
出版年
2023年 | 1470篇 |
2022年 | 2479篇 |
2021年 | 5954篇 |
2020年 | 3464篇 |
2019年 | 5881篇 |
2018年 | 6927篇 |
2017年 | 4995篇 |
2016年 | 5432篇 |
2015年 | 6329篇 |
2014年 | 9160篇 |
2013年 | 12734篇 |
2012年 | 19654篇 |
2011年 | 20697篇 |
2010年 | 11526篇 |
2009年 | 10145篇 |
2008年 | 18113篇 |
2007年 | 19053篇 |
2006年 | 18875篇 |
2005年 | 18842篇 |
2004年 | 17664篇 |
2003年 | 16358篇 |
2002年 | 15393篇 |
2001年 | 3118篇 |
2000年 | 2844篇 |
1999年 | 3200篇 |
1998年 | 3204篇 |
1997年 | 2631篇 |
1996年 | 2273篇 |
1995年 | 2147篇 |
1994年 | 1789篇 |
1993年 | 1613篇 |
1992年 | 1573篇 |
1991年 | 1388篇 |
1990年 | 1246篇 |
1989年 | 1143篇 |
1988年 | 1092篇 |
1987年 | 1067篇 |
1986年 | 1075篇 |
1985年 | 1060篇 |
1984年 | 1286篇 |
1983年 | 1173篇 |
1982年 | 1387篇 |
1981年 | 1328篇 |
1980年 | 1157篇 |
1979年 | 735篇 |
1978年 | 763篇 |
1977年 | 659篇 |
1976年 | 611篇 |
1975年 | 495篇 |
1974年 | 521篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
Angelo Lipira David Limbrick Bruce Haughey Phillip Custer Michael R. Chicoine 《Skull base》2009,19(4):303-309
103.
104.
B Bonet M Viana I Sánchez-Vera A Quintanar J Martínez M Espino 《Diabetic medicine》2007,24(11):1192-1198
AIMS: The aims of our study were to determine if insulin resistance is associated with increased plasma levels of non-esterified fatty acids (NEFA), glycerol, 3-hydroxybutyrate and triglycerides in obese children. We also studied whether the presence of acanthosis nigricans (AN) led to further alterations in the above parameters. METHODS: A total of 101 children were studied on their first visit to the paediatric endocrine clinic. Seventy-four were obese, 30 of them with AN. The remaining 27 were non-obese healthy children (control group). NEFAs, glycerol, triglycerides, 3-hydroxybutyrate, insulin, leptin, adiponectin and glucose were determined in blood samples obtained after overnight fasting. The insulin resistance index (IRI) was calculated following the homeostasis model assessment (HOMA). Data from the three groups were compared using appropriate statistical tests. RESULTS: No differences in age, sex ratio and pubertal stage were observed among the three groups. The group of children with the highest body mass index (BMI) showed higher plasma levels of insulin and leptin, higher IRI and lower plasma levels of adiponectin. As insulin and IRI increased, NEFA and 3-hydroxybutyrate decreased and triglycerides increased. When obese children were categorized by BMI, the presence of AN further exacerbated these differences. CONCLUSIONS: In obese children, insulin resistance is associated with plasma lipid alterations suggestive of both decreased adipose tissue lipolysis and hepatic beta-oxidation and increased hepatic synthesis of triglycerides. Such a metabolic condition may facilitate fat storage and hinder weight loss. 相似文献
105.
106.
Understanding the minimum clinically important difference: a review of concepts and methods. 总被引:2,自引:0,他引:2
Anne G Copay Brian R Subach Steven D Glassman David W Polly Thomas C Schuler 《The spine journal》2007,7(5):541-546
BACKGROUND CONTEXT: The effectiveness of spinal surgery as a treatment option is currently evaluated through the assessment of patient-reported outcomes (PROs). The minimum clinically important difference (MCID) represents the smallest improvement considered worthwhile by a patient. The concept of an MCID is offered as the new standard for determining effectiveness of a given treatment and describing patient satisfaction in reference to that treatment. PURPOSE: Our goal is to review the various definitions of MCID and the methods available to determine MCID. STUDY DESIGN: The primary means of determining the MCID for a specific treatment are divided into anchor-based and distribution-based methods. Each method is further subdivided and examined in detail. METHODS: The overall limitations of the MCID concept are first identified. The basic assumptions, statistical biases, and shortcomings of each method are examined in detail. RESULTS: Each method of determining the MCID has specific shortcomings. Three general limitations in the accurate determination of an MCID have been identified: the multiplicity of MCID determinations, the loss of the patient's perspective, and the relationship between pretreatment baseline and posttreatment change scores. CONCLUSIONS: An ideal means of determining the MCID for a given intervention is yet to be determined. It is possible to develop a useful method provided that the assumptions and methodology are initially declared. Our efforts toward the establishment of a MCID will rely on the establishment of specific external criteria based on the symptoms of the patient and treatment intervention being evaluated. 相似文献
107.
Trauma und Berufskrankheit - Nur 0,4–1% aller Frakturen betreffen die Skapula, die meisten davon können erfolgreich konservativ funktionell behandelt werden. Zur Identifikation der... 相似文献
108.
S. Champain Th. David Ch. Mazel A. Mitulescu W. Skalli 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2007,17(4):337-347
Adult low-grade isthmic spondylolisthesis is often treated by posterolateral lumbar fusion (PLF), with a certain rate of complications and non-return to work. Alternatives to fusion, like pars defect repair (PDR), were used with encouraging results in young populations and athletes but their outcomes were rarely evaluated for adult patients. This retrospective study quantitatively analysed the long-term outcomes in adult isthmic spondylolisthesis patients treated by PLF or PDR. At a mean follow-up of 9 years, clinical, socio-professional, radiological data and Stauffer-Coventry score were available for 59 patients (39 cases treated by PLF and 20 treated by PDR). The overall clinical outcomes were comparable in both populations (88% in the PDR and 80% in PLF group 1), with a larger proportion of excellent results (56% vs. 10%) and of return to work in the PDR group. Radiological quantitative analysis highlighted stationary evolution and comparable outcomes for the two groups, except for vertebral slip evolution and adjacent level degeneration rate. Abnormal kinematic patterns outlined for PLF patients 20% of pseudarthrosis and 42% of adjacent levels hypermobility and for PDR ones low mobility for the levels adjacent to instrumented vertebra in 40% of cases. Quantified analysis of biomechanical parameters interpreted altogether with clinical outcome, complications and economic burden of the patient, provided accurate objective data for a better appreciation of global outcome, allowing for a preliminary view on long-term outcomes after PDR in adult low-grade isthmic spondylolisthesis, which were not presented in literature until now. 相似文献
109.
David H. Wilson Catherine R. Chittleborough Kerry Kirke Janet F. Grant Richard E. Ruffin 《Sozial- und Pr?ventivmedizin》2004,13(5):406-412
Objectives: Heavy smokers are a segment of the smoking population who are at increased risk of smoking-related morbidity and least likely to achieve cessation. This study identifies the impact of heavy smoking on quality of life by gender and describes the subpopulation for improved targeting.Methods: South Australian representative population data (n = 3010) was used to compare the health-related quality of life status of male and female heavy smokers as assessed by the SF-36. 相似文献
110.
David A. Davis 《Canadian Medical Association journal》2004,171(2):149-150