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Characterising the safety of clomiphene citrate in male patients through prostate‐specific antigen,haematocrit, and testosterone levels
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James M Hotaling Darshan P Patel Christopher Vendryes Natalya A Lopushnyan Angela P Presson Chong Zhang Charles H Muller Thomas J Walsh 《Asian journal of andrology》2016,18(1):35-38
Our objective was to identify predictors of improved postthaw semen quality in men with testicular cancer banking sperm for fertility preservation. We reviewed 173 individual semen samples provided by 67 men with testicular germ cell tumor (TGCT) who cryopreserved sperm before gonadotoxic treatment between 1994 and 2010 at our tertiary university medical center. Our main outcomes measures were independent predictors for the greater postthaw total motile count (TMC) in men with TGCT. Men with NSGCT were more likely to be younger (P < 0.01) and had high cancer stage (II or III, P < 0.01) compared with men with seminoma. In our multiple regression model, NSGCT histology, use of density gradient purification, and fresh TMC > median fresh TMC each had increased odds of a postthaw TMC greater than median postthaw TMC. Interestingly, age, advanced cancer stage (II or III), rapid freezing protocol, and motility enhancer did not show increased odds of improved postthaw TMC in our models. In conclusion, men with TGCT or poor fresh TMC should consider preserving additional vials (at least 15 vials) before oncologic treatment. Density gradient purification should be routinely used to optimize postthaw TMC in men with TGCT. Larger, randomized studies evaluating cancer stage and various cryopreservation techniques are needed to assist in counseling men with TGCT regarding fertility preservation and optimizing cryosurvival. 相似文献
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Severe combined immunodeficiency (SCID) is a lethal disease unless allogeneic bone marrow transplantation (BMT), preferably
from a family related HLA identical donor (RID) is given. Previously, some patients received HLA-mismatched related donors
(MMRD) BMT, which often resulted in slow immune reconstitution and variable survival. Alternatively, HLA-matched unrelated
donors (MUD) BMT have been suggested. Recently, we have directly compared outcome of patients with SCID who received either
MMRD or MUD BMT. Survival after MUD BMT was significantly better than after MMRD BMT. Patients who received MUD BMT also had
better engraftment of donor cells and immune reconstitution. Recent reports from other centers confirm these results finding
that MUD BMT provides excellent survival and better immune reconstitution for patients with SCID. In conclusion, MUD BMT appears
vastly superior to MMRD BMT and should be offered as first choice of treatment for patients with SCID when RID is unavailable.
Presented at the First Robert A Good Society Symposium, St. Petersburg, FL 2006. 相似文献
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Darshan Zala BSc MSc 《Health & social care in the community》2018,26(1):35-40
Most research concerning the causes of obesity has focused on macroeconomic trends or individual‐level determinants relating to socioeconomic status. There is now growing interest in the psychosocial determinants of obesity. Little research has been conducted into wide‐scale peer effects and so the aim of this study was to determine whether regional and district peer effects determine individual‐level obesity in the UK. Data from the British Household Panel Survey (for the years 2004 and 2006) were used to model individual‐level BMI and probability of obesity as a function of regional and district BMI, controlling for a variety of other variables. Instrumental variable techniques were used to investigate simultaneity bias. We found no statistically significant regional peer effect in the UK. For men, we found that a 1 point increase in average district BMI increased individual BMI by 0.640 and probability of being obese by 1.9% points; for women, BMI increased by 0.230 and probability of being obese by 1.6% points. Men appear to be more susceptible to these effects than women. Peer effects at the district level may have played a significant role in the rise of obesity in the UK. Further research must aim to disentangle the two routes by which these processes are theorised to function. 相似文献
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Moulana Ilyas Dalal is the Muslim chaplain at Dewsbury and District Hospital, where he combines pastoral care with teaching healthcare staff about Islamic practices and culture. 相似文献