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121.
Ambrosetti P Francis K De Peyer R Frossard JL 《Diseases of the colon and rectum》2008,51(9):1345-1349
Purpose This prospective study was designed to find the incidence of symptomatic anastomotic stenosis after elective laparoscopic
sigmoidectomy for diverticular disease.
Methods Sixty-eight patients who underwent elective laparoscopic sigmoidectomy with double-stapling colorectal anastomosis between
November 1998 and June 2007 were included. Follow-up after hospitalization was performed by using sequential rectoscopy for
all patients. Symptomatic patients with anastomotic stricture were treated.
Results No patient died postoperatively and no patient had anastomotic leak or abdominal septic complication. Twenty-two patients
(32 percent) had postoperative symptoms that suggested anastomotic stenosis; 12 of them (17.6 percent) eventually needed dilatation
of their anastomosis (median diameter of the stenosis: 7 mm) a mean time of 176 days postoperatively. Eight patients had only
one session, three patients had two sessions, and one patient had three sessions. There were no complications and all patients
were symptom-free after dilatation. Age, sex, obesity, hypertension, diabetes, and vascular preservation had no influence
on the risk of anastomotic stenosis.
Conclusions Incidence of symptomatic anastomotic stenosis after elective laparoscopic sigmoidectomy is high (17.6 percent). No risk factor
could be identified. Endoscopic dilatations were successful without complication in all cases. Regular rigid rectoscopy definitely
should be part of the postoperative follow-up in symptomatic patients. 相似文献
122.
Stéphan Zientara Corinne Sailleau Cyril Viarouge Dirck H?per Martin Beer Maria Jenckel Bernd Hoffmann Aurore Romey Labib Bakkali-Kassimi Aurore Fablet Damien Vitour Emmanuel Bréard 《Emerging infectious diseases》2014,20(12):2123-2125
During 2000–2013, 4 genotypes of bluetongue virus (BTV) were detected in Corsica, France. At the end of 2013, a compulsory BTV-1 vaccination campaign was initiated among domestic ruminants; biological samples from goats were tested as part of a corresponding monitoring program. A BTV strain with nucleotide sequences suggestive of a novel serotype was detected. 相似文献
123.
BackgroundThe prevalence of sexual assault and harassment at universities is unclear because of under-reporting. Furthermore, student perceptions of vulnerability to sexual assault and how these relate to alcohol consumption are unknown. The present study assesses the prevalence of sexual assault and harassment in a student sample, and how this relates to issues of vulnerability and alcohol use.MethodsParticipants were recruited via a weekly email of notices that is sent to all students attending a town-based Scottish university of about 7200 students. The study was approved by the university ethics committee, and all participants gave informed consent before participating. The online survey was available in November, 2013, and included validated scales examining personal experience of sexual harassment and assault, perception of own and peers' vulnerability to sexual assault, and the Alcohol Use Disorder Identification Test (AUDIT). Data were analysed with χ2 and t tests.FindingsThe survey was completed by 135 female and 40 male students, aged 17–56 years (mean 21·9, SD 5·4), 84 (48%) of whom were in their first year of study. There was no significant difference in the proportion of male students (22·5%) and female students (37·0%) who reported having experienced some form of sexual harassment or assault at the university. Participants perceived themselves as significantly less vulnerable than same-sex peers (t(df 160)=6·10, 95% CI ?1·09 to ?0·55; p<0·0001) and judged peers to significantly underestimate their own vulnerability (t(df 159)=4·86, 0·40 to 0·95; p<0·0001). Controlling for sex, AUDIT did not predict judgments of own vulnerability (β=0·02, 95% CI ?0·03 to 0·06, p=0·49), but hazardous drinkers were more likely to report experiences of sexual harassment than non-hazardous drinkers (χ2(df 2)=20·98, p<0·0001).InterpretationPrevalence rates for experiencing sexual harassment or assault were high, and participants underestimated their own vulnerability compared with peers. Although hazardous drinkers were more likely to report experiencing sexual harassment or assault than non-hazardous drinkers, this finding was not shown in their judged vulnerability, again suggesting a misperception. The role of alcohol and vulnerability misperceptions should be considered in future interventions. The study was limited by oversampling female first-year students, thereby producing a non-representative sample.FundingNone. 相似文献
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126.
Mohamed-Aziz Barkaoui Emma Queheille Nathalie Aladjidi Geneviève Plat Eric Jeziorski Despina Moshous Anne Lambilliotte Kamila Kebaili Hélène Pacquement Guy Leverger Ludovic Mansuy Natacha Entz-Werlé Damien Bodet Pascale Schneider Anne Pagnier Anne Lutun Marion Gillibert-Yvert Fréderic Millot Fabienne Toutain Yves Reguerre Caroline Thomas Abdelatif Tazi Jean-François Emile Jean Donadieu Sébastien Héritier 《British journal of haematology》2020,191(5):825-834
The nucleoside analogue, 2-chlorodeoxyadenosine (2CDA), was reported to be an active treatment for childhood Langerhans cell histiocytosis (LCH) without risk organ (RO−) involvement. However, we lack data on long-term effects of 2CDA treatment, including the disease reactivation rate, permanent sequelae and long-term tolerance. This study included 44 children from the French LCH registry, treated for a RO− LCH with 2CDA monotherapy (median number of six courses). The median age at the beginning of 2CDA was 3·6 years (range, 0·3–19·7 years) and the median follow-up after was 5·4 years (range, 0·6–15·1 years). Objective response to 2CDA was observed in 25 patients (56·8%), while six patients (13·6%) had stable disease and 13 patients (29·5%) exhibited progressive disease. Among patients without progression, only two experienced disease reactivation after 2CDA discontinuation. The five-year cumulative incidence of disease progression or reactivation after 2CDA therapy initiation was 34·3%. The lymphopenia reported in all cases [72% below absolute lymphocyte count (ALC) of 0·5 G/l], was addressed with appropriate prophylactic measures. Other toxicities above grade 2 were uncommon, and no second malignant neoplasm or neuropathy was reported. The five-year overall survival was 97·7%. In conclusion, we could confirm that 2CDA monotherapy was a beneficial long-term therapy for treating patients with RO− LCH. Appropriate management of induced immune deficiency is mandatory. 相似文献
127.
Yasmine Ouzegdouh Mammasse Christophe Chenet Damien Drubay Corinne Martageix Jean-Pierre Cartron William Vainchenker Rachel Petermann 《British journal of haematology》2020,190(5):787-798
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is the consequence of platelet destruction by maternal alloantibodies against fetal human platelet antigens (HPA). This may result in intracranial haemorrhages (ICH) or even fetal death. Currently, fetal HPA genotyping is performed using invasive procedures. Here, we carried out a proof-of-concept study for non-invasive prenatal diagnosis of fetal platelet genotyping in four HPA systems (HPA-1, -3, -5 and-15) by droplet digital polymerase chain reaction (ddPCR) using cell-free DNA extracts from the plasma of 47 pregnant women with suspected, or history of, FNAIT. Results showed that 74% (35/47) of pregnant women presented incompatibility in at least one HPA system, and 38% (18/47) of cases presented HPA-1 incompatibility, including nine women with multiple incompatibilities. ICH occurred in one case of profound fetal thrombocytopenia with HPA-15 incompatibility, confirming the need for non-invasive prenatal genotyping in systems other than HPA-1. Fetal HPA genotypes predicted by ddPCR were confirmed in all FNAIT cases after amniocentesis or delivery. Fetal HPA genotyping on maternal plasma based on ddPCR is a fast, safe and reliable non-invasive method. This technique will be useful for the early identification of pregnancies at high risk of FNAIT requiring antenatal management to minimize the risk of fetal/neonatal haemorrhage. 相似文献
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129.
Damien Collison John D. McClure Colin Berry Keith G. Oldroyd 《Clinical cardiology》2020,43(5):414-422
Post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) ≥0.90 confers an improved cardiac prognosis. There are currently limited data available to determine how often it is possible to improve an angiographically acceptable but physiologically suboptimal result. A physiology-guided optimization strategy can achieve a clinically meaningful increase in the proportion of patients achieving a final post-PCI FFR ≥0.90 compared to standard care. Following angiographically successful PCI procedures, 260 patients will be randomized (1:1) to receive either a physiology-guided incremental optimization strategy (intervention group) or blinded post-PCI coronary physiology measurements (control group). Patients undergoing successful, standard-of-care PCI for either stable angina or non-ST-segment-elevation myocardial infarction who meet the study's inclusion and exclusion criteria will be eligible for randomization. The primary endpoint is defined as the proportion of patients with a final post-PCI FFR result ≥0.90. Secondary endpoints include change from baseline in Seattle Angina Questionnaire and EQ-5D-5L scores at 3 months and the rate of target vessel failure and its components (cardiac death, myocardial infarction, stent thrombosis, unplanned rehospitalization with target vessel revascularization) at 3 months and 1 year. 260 individual patients were successfully randomized between March 2018 and November 2019. Key baseline demographics of the study population are reported within. TARGET FFR is an investigator-initiated, prospective, single-center, randomized controlled trial of an FFR-guided PCI optimization strategy. The study has completed recruitment and is now in clinical follow-up. It is anticipated that primary results will be presented in Autumn 2020. ClinicalTrials.gov Identifier: NCT03259815. [Correction added on Apr 3 2020, after first online publication: Clinical Trials identifier added.] 相似文献