首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3439087篇
  免费   305709篇
  国内免费   13847篇
耳鼻咽喉   47330篇
儿科学   108900篇
妇产科学   87702篇
基础医学   549414篇
口腔科学   93024篇
临床医学   312410篇
内科学   611430篇
皮肤病学   89329篇
神经病学   297247篇
特种医学   137986篇
外国民族医学   300篇
外科学   533776篇
综合类   106016篇
现状与发展   24篇
一般理论   2266篇
预防医学   293441篇
眼科学   78676篇
药学   237441篇
  24篇
中国医学   9550篇
肿瘤学   162357篇
  2021年   55057篇
  2020年   35058篇
  2019年   58055篇
  2018年   71286篇
  2017年   54262篇
  2016年   59949篇
  2015年   74089篇
  2014年   108381篇
  2013年   173408篇
  2012年   92042篇
  2011年   91865篇
  2010年   116480篇
  2009年   120968篇
  2008年   78999篇
  2007年   82179篇
  2006年   92804篇
  2005年   88336篇
  2004年   90344篇
  2003年   81275篇
  2002年   70404篇
  2001年   111010篇
  2000年   104600篇
  1999年   102192篇
  1998年   66162篇
  1997年   63786篇
  1996年   61984篇
  1995年   57740篇
  1994年   51750篇
  1993年   48350篇
  1992年   73510篇
  1991年   70220篇
  1990年   66543篇
  1989年   65116篇
  1988年   60375篇
  1987年   59034篇
  1986年   55858篇
  1985年   55974篇
  1984年   50422篇
  1983年   45759篇
  1982年   42548篇
  1981年   39969篇
  1980年   37669篇
  1979年   41768篇
  1978年   36558篇
  1977年   33119篇
  1976年   30450篇
  1975年   29030篇
  1974年   30269篇
  1973年   29033篇
  1972年   27036篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
53.
54.
55.
56.
Purpose

This paper describes the design of a theory-informed pragmatic intervention for adolescent perinatal depression in primary care in Nigeria.

Methods

We conducted Focus Group Discussions (FGDs) among 17 adolescent mothers and 25 maternal health care providers with experience in the receipt and provision of care for perinatal depression. The Consolidated Framework for Implementation Research (CFIR) was used to systematically examine the barriers and facilitators affecting adolescent mothers' use of an existing intervention package for depression. The Theoretical Domain Framework (TDF) and the Capability, Opportunity, Motivation, Behaviour (COM-B) model were used to analyze the results of the data across the five CFIR domains.

Results

FGD analysis revealed that care providers lacked knowledge on approaches to engage young mothers in treatment. Young mothers had poor treatment engagement, low social support, and little interest in parenting. A main characteristic of the newly designed intervention is the inclusion of age-appropriate psychoeducation supported with weekly mobile phone calls, to address treatment engagement and parenting behaviours of young mothers. Also in the outer setting, low social support from relatives was addressed with education, “as need arises” phone calls, and the involvement of "neighborhood mothers”. In the inner settings, care providers’ behaviour is addressed with training to increase their capacity to engage young mothers in treatment.

Conclusion

A theory-based approach helped develop an age-appropriate intervention package targeting depression and parenting skills deficit among perinatal adolescents in primary maternal care and in which a pragmatic use of mobile phone was key.

  相似文献   
57.
Major depressive disorder and other neuropsychiatric disorders are often managed with long-term use of antidepressant medication. Fluoxetine, an SSRI antidepressant, is widely used as a first-line treatment for neuropsychiatric disorders. However, fluoxetine has also been shown to increase the risk of metabolic diseases such as non-alcoholic fatty liver disease. Fluoxetine has been shown to increase hepatic lipid accumulation in vivo and in vitro. In addition, fluoxetine has been shown to alter the production of prostaglandins which have also been implicated in the development of non-alcoholic fatty liver disease. The goal of this study was to assess the effect of fluoxetine exposure on the prostaglandin biosynthetic pathway and lipid accumulation in a hepatic cell line (H4-II-E-C3 cells). Fluoxetine treatment increased mRNA expression of prostaglandin biosynthetic enzymes (Ptgs1, Ptgs2, and Ptgds), PPAR gamma (Pparg), and PPAR gamma downstream targets involved in fatty acid uptake (Cd36, Fatp2, and Fatp5) as well as production of 15-deoxy-Δ12,14PGJ2 a PPAR gamma ligand. The effects of fluoxetine to induce lipid accumulation were attenuated with a PTGS1 specific inhibitor (SC-560), whereas inhibition of PTGS2 had no effect. Moreover, SC-560 attenuated 15-deoxy-Δ12,14PGJ2 production and expression of PPAR gamma downstream target genes. Taken together these results suggest that fluoxetine-induced lipid abnormalities appear to be mediated via PTGS1 and its downstream product 15d-PGJ2 and suggest a novel therapeutic target to prevent some of the adverse effects of fluoxetine treatment.  相似文献   
58.
59.
Cognitive Therapy and Research - Despite interest in psychological inflexibility as a marker of suicide risk, no measure of psychological inflexibility specific to SI exists. The present study...  相似文献   
60.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号